A5003734900- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sulfur Compounds in Biology
- Click Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Nanopore and Nanochannel Transport Studies
- Microfluidic and Capillary Electrophoresis Applications
- Sulfur-Based Synthesis Techniques
- Redox biology and oxidative stress
- Advanced Computational Techniques and Applications
- Cellular transport and secretion
- Power Systems and Technologies
- Extracellular vesicles in disease
- Chemical Synthesis and Analysis
- Smart Grid and Power Systems
- Lipid Membrane Structure and Behavior
- Thermochemical Biomass Conversion Processes
- Neonatal Health and Biochemistry
- Dendrimers and Hyperbranched Polymers
- Iron and Steelmaking Processes
China University of Geosciences
2019-2024
Hangzhou Normal University
2024
Tianjin University of Technology
2017-2019
Yunnan Normal University
2018
Kunming University
2018
Jiangxi Agricultural University
2018
North China University of Science and Technology
2017
Hubei Engineering University
2017
A high brightness red fluorescent probe (S-BODIPY) has been developed for the sensitive and specific imaging of HClO/ClO– in vitro vivo. This exhibits some distinctive features such as excellent resistance to photobleaching, a fluorescence brightness, selectivity, well good biocompatibility. Upon oxidation thio-ether group into sulfoxide, showed noticeable ratiometric response toward ClO– with fast (within 30 s) low detection limit (59 nM). The demonstrated successful exogenous endogenous...
Abstract Theranostic systems by integrating the tumor imaging and therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite great developments, their clinical application is still in nascent stage, owing to unsatisfied quality limited efficacy. Fortunately, emerging of aggregation‐induced emission (AIE) molecules with unique fluorescence property offers an opportunity solve problem. Besides, further utilizing microenvironments external...
A colorimetric and fluorescent probe <bold>ER-ClO</bold> was developed to detect cellular hypochlorite with high selectivity sensitivity.
We first report several bright solid-state red-emissive BODIPYs with high fluorescence quantum yields for unusual high-contrast mechanohypsochromism.
In this work, we reported an anthracene carboxyimide-based chemosensor (AC-Phos) for colorimetric and ratiometric fluorescence detection of highly toxic phosgene, which displayed rapid response (<5 min) toward phosgene with a high selectivity low limit (2.3 nM). Furthermore, facile testing membrane polystyrene immobilizing has been fabricated real-time visualizing gaseous phosgene.
Nanochannel technology has emerged as a powerful tool for label-free and highly sensitive detection of protein folding/unfolding status. However, utilizing the inner walls nanochannel array may cause multiple events even proteins with same conformation, posing challenges accurate identification. Herein, we present platform to detect unfolded through electrical optical signals using arrays outer-surface probes. The principle relies on specific binding between maleimide groups in probes...
Aberrant levels of cysteine (Cys) in living cells are closely related to some diseases; thus<italic>in situ</italic>visualization intracellular Cys is very helpful for the investigation physiological and pathological processes.
To overcome a series of challenges in tumor therapy, modular-agent probes (MAPs) comprised various functional modules have been proposed. Researchers tried to optimize the MAPs by exploiting new or increasing numbers module, while neglecting configuration modules. Here, we focus on different spatial arrangements existing By utilizing tetraphenylethylene (TPE) derivative with stereochemical structure and dual modifiable end-group sites as small molecule scaffold, two same modular agents...
Fluorescence imaging-guided navigation for cancer surgery has a promising clinical application. However, pan-cancer encompasses wide variety of types with significant heterogeneity, resulting in the lack universal and highly contrasted fluorescent probes surgical navigation. Here, we developed an aggregation-induced emission (AIE) probe (MI-AIE-TsG, MAT) dual activation MAT weakly activates fluorescence by targeting SUR1 protein on endoplasmic reticulum (ER) through TsG group. Subsequently,...
Realizing protein analysis in organelles of living cells is great significance for developing diagnostic and therapeutic methods diseases. Fluorescent-labeled antibodies with well imaging performance high affinity are classical biochemical tools analysis, while due to the inability effectively enter into cells, not mention uncontrollable reaction sites that might cause inactivation when chemically modification, they hard apply cells. Inspired by structure fluorescent-labeled antibodies, we...
Impairment of the protein quality control network leads to accumulation unfolded and aggregated proteins. Direct detection in cells may provide possibility for early diagnosis neurodegenerative diseases. Here a new platform based on peptide-conjugated thiol-reactive aggregation-induced emission fluorogen (AIEgen), named MI-BTD-P (or D1), labeling tracking proteins is reported. In vitro experiments with model show that non-fluorescent D1 only becomes highly fluorescent when reacted thiol...
In this study, we report a colorimetric and ratiometric fluorescent probe with multiple merits for visual detection of S<sub>2</sub>O<sub>5</sub><sup>2−</sup> in food living cell.
A N-2-phenylethyl-substituted 1,4-dihydropyridine derivative (NDHP) containing 5,5-dimethylcyclohexane-1,3-dione and naphthylethylene was designed synthesized. NDHP acts as a multifunctional fluorescent sensor in dual phases. The crystal structure analysis confirms that the molecules have highly twisted conformations. conformation results aggregation-induced emission properties solid-state emission, by restricting intramolecular free rotation aggregated or solid state. In state, exhibits...
Cell membrane transport is the first and crucial step for bioprobes to realize diagnosis, imaging, therapy in cells. However, during this transport, there a trade-off between anchoring internalization steps, which will seriously affect efficiency. In past, because interaction probes cell constant, challenge hard solve. Here, we proposed strategy regulate affinity of multi-module that enabled probe have strong weak internalization. Specifically, defined as LK-M-NA was constructed, consisted...
Metallurgical coke accounts for a significant portion of the costs associated with blast furnace operations. The reactivity index (CRI) and strength after reaction (CSR), determined via Nippon Steel Corporation test, are most popular indexes estimating high-temperature properties coke. Multiple factors affect solution-loss reaction, CRI CSR depend on composition structure pore is one important affecting this reaction. effect was by quantitatively evaluating 10 types In each case,...
Abstract Realizing protein analysis in organelles of living cells is great significance for developing diagnostic and therapeutic methods diseases. Fluorescent‐labeled antibodies with well imaging performance high affinity are classical biochemical tools analysis, while due to the inability effectively enter into cells, not mention uncontrollable reaction sites that might cause inactivation when chemically modification, they hard apply cells. Inspired by structure fluorescent‐labeled...
Abstract To overcome a series of challenges in tumor therapy, modular‐agent probes (MAPs) comprised various functional modules have been proposed. Researchers tried to optimize the MAPs by exploiting new or increasing numbers module, while neglecting configuration modules. Here, we focus on different spatial arrangements existing By utilizing tetraphenylethylene (TPE) derivative with stereochemical structure and dual modifiable end‐group sites as small molecule scaffold, two same modular...
本文构建了一种基于苯并吲哚季铵盐结构的荧光探针用于检测SO2衍生物。该荧光探针能够快速、灵敏、高选择性地检测HSO3-和SO32-，并显示出颜色和荧光变化双重响应。其比率荧光强度（I462/I588）与HSO3-的浓度（0～16 μmol/L）之间具有良好的线性关系，检测限低至12 nmol/L。1HNMR表明该探针的响应机制为1，4-亲核加成反应。激光共聚焦荧光成像结果表明，CZBI具有良好的细胞膜通透性，并且可以通过比率荧光成像实现对细胞内SO2衍生物的监测。
Abstract Nanochannel technology has emerged as a powerful tool for label‐free and highly sensitive detection of protein folding/unfolding status. However, utilizing the inner walls nanochannel array may cause multiple events even proteins with same conformation, posing challenges accurate identification. Herein, we present platform to detect unfolded through electrical optical signals using arrays outer‐surface probes. The principle relies on specific binding between maleimide groups in...