Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side...

Ultra-small gold nanoclusters (Au NCs) are highly promising materials for tumor imaging and therapy because of their low toxicity, intrinsic fluorescence, the availability multifunctional groups covalent linkage diverse bioactive molecules. Au NCs stabilized by bovine serum albumin (BSA) were prepared via an improved "green" synthetic routine. To ameliorate selective affinity high folate receptor (FR) expressing tumors, folic acid (FA) was immobilized on surface NCs. Subsequently, a...

Nanocatalytic therapy (NCT) has made great achievements in tumor treatments due to its remarkable enzyme-like activities and high specificity. Nevertheless, the limited types of nanozymes undesirable microenvironments (TME) greatly weaken therapeutic efficiency. Developing a combination integrating NCT other strategies is significance for optimal treatment outcomes. Herein, AuPt-loaded Cu-doped polydopamine nanocomposite (AuPt@Cu-PDA) with multiple was rationally designed, which integrated...

Tumor-associated macrophages (TAMs) play pivotal roles in tumor development. As primary contents of environment (TME), TAMs secrete inflammation-related substances to regulate tumoral occurrence and There are two kinds TAMs: the tumoricidal M1-like protumoral M2-like TAMs. Reprogramming from immunosuppressive M2 immunocompetent M1 phenotype is considered a feasible way improve immunotherapeutic efficiency. Notably, nanomaterials show great potential for biomedical fields due their...

Abstract Reactive oxygen species (ROS)‐mediated emerging treatments exhibit unique advantages in cancer therapy recent years. While the efficacy of ROS‐involved tumor is greatly restricted by complex microenvironment (TME). Herein, a dual‐metal CaO 2 @CDs‐Fe (CCF) nanosphere, with TME response and regulation capabilities, are proposed to improve ROS lethal power multiple cascade synergistic therapeutic strategy domino effect. In weak acidic TME, CCF will decompose, accompanied intracellular...

Abstract Pyroptosis, a new mode of regulatory cell death, holds promising prospect in tumor therapy. The occurrence pyroptosis can trigger the release damage‐associated molecular patterns (DAMPs) and activate antitumor immune response. Moreover, enhancing intracellular reactive oxygen species (ROS) generation effectively induce pyroptosis. Herein, an integrated nanoplatform (hCZAG) based on zeolitic imidazolate framework‐8 (ZIF‐8) with Cu 2+ Zn as active nodes glucose oxidase (GOx) loading...

An Ag₂S QD fluorescent sensor for highly selective and sensitive Cu²⁺ detection was developed the quenching mechanism investigated.

Chemodynamic therapy (CDT) is a cancer treatment that converts endogenous H2O2 into hydroxyl radicals (˙OH) through Fenton reaction to destroy cells. However, there are still some challenges in accelerating the of CDT and improving biodegradability nanocatalysts. Herein, multifunctional biomimetic BPQDs-Cu@GOD (BCG) nanocatalyst for boosting synergistically enhanced H2O2-guided photothermal reported. Cu2+ BCG can be reduced Cu+ by black phosphorus quantum dots (BPQDs), triggering...

With its rapid development, the rural area of Southwest China has been puzzled by waste management problem, especially for increasing solid and water pollution from domestic waste. Therefore, in order to efficiently effectively manage China, 22 villages were selected randomly analyse characteristics waste, influence factors resident's willingness participation questionnaires, field samplings laboratory tests. The results indicated that generation was 178 g d(-1) per capita it mainly composed...

An ultrasmall near-infrared Zn-doped Cu₂S quantum dots was invented for chemodynamic therapy with apoptosis induced and autophagy activated.

Chiral nanomaterials have great potential in improving the clinical therapeutic effect due to unique chiral selectivity of biosystems. However, such a promising strategy has so far received little attention cancer treatment. Here, we report first Fenton catalyst, d-/l-penicillamine-modified Cu2-xSe nanoparticles (d-/l-NPs), for enhanced synergistic chemodynamic therapy (CDT) and photothermal (PTT) under second near-infrared (NIR-II) light irradiation. The study NPs on cells shows that d-NPs...

Advanced method to solve problems of tumor hypoxia and off-targeting in SDT: (1) transport O 2 through nanocarriers, (2) utilize catalase or nanozymes generate , (3) improve targeting efficiency by modifying coating structure.

Copper indium selenide (CISe) quantum dots (QDs) are a class of extremely appealing candidates for various biological applications due to their composition- and size-dependent photoluminescence low toxicity. However, the synthesis high-quality water-soluble CISe QDs with controlled composition in aqueous phase is still great challenge, which limits applications. Moreover, effects copper content on fluorescence corresponding mechanism subject debate. Herein, composition-tunable Cu-deficient...

This review summarizes recent advancements of 2D supramolecular membranes for separations. topic can provide new insights on developing with high selectivity, mild flux, good stability and appreciable reversibility.

The colorimetric sensor has made great achievements in glucose sensing and diabetes prediction due to its simplicity, visualization, lack of need for sophisticated instruments. noninvasive sampling method received more attention. Herein, a agarose gel was constructed by combining Cu-doped carbon nanowires (CuCNWs) with excellent peroxidase-like activity oxidase (GOx). CuCNWs can effectively catalyze the oxidation 3,3′,5,5′-tetramethylbenzidine (TMB) maximum catalytic rate 12.5 × 10–8 M s–1,...