A5019409268- Spinal Cord Injury Research
- Extracellular vesicles in disease
- Advanced Nanomaterials in Catalysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Mesoporous Materials and Catalysis
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Curcumin's Biomedical Applications
- Carbon and Quantum Dots Applications
- Conducting polymers and applications
- Nanocluster Synthesis and Applications
- Spinal Dysraphism and Malformations
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
- Nanomaterials for catalytic reactions
- 2D Materials and Applications
- Organic Light-Emitting Diodes Research
- Thin-Film Transistor Technologies
- Advanced Drug Delivery Systems
- Immune Cell Function and Interaction
- Nanoporous metals and alloys
- Diabetic Foot Ulcer Assessment and Management
- Advanced materials and composites
University of Science and Technology of China
2025
Anhui Provincial Hospital
2025
Jinzhou Medical University
2015-2024
Tianjin University of Technology
2018-2024
Guizhou University
2023
Southern Taiwan University of Science and Technology
2015-2021
Shandong University
2013-2016
State Key Laboratory of Microbial Technology
2013-2016
Shenyang Pharmaceutical University
2010-2012
Chunghwa Picture Tubes (Taiwan)
2006
Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the exploration additional pathogenic factors and development new therapeutics are needed. Here, strong correlations among cell-free DNA (cfDNA) level inflammatory response in clinical synovial fluid samples RA activity discovered. The important role cfDNA collagen-induced (CIA) murine model is also demonstrated. Building on these findings, novel therapeutic based anti-inflammatory (M2) macrophage-derived...
This study aims to investigate the potential therapeutic effect of exosomes derived from macrophages loaded with curcumin (Exos-cur) on healing diabetic wounds. As a new type biomaterial, Exos-cur has better stability, anti-inflammation, and antioxidation biological activity. In in vitro experiments, can promote proliferation, migration, angiogenesis HUVECs (human umbilical vein endothelial cells) while reducing ROS (reactive oxygen species) produced by induced high glucose, regulating...
Uncontrollable inflammation and nerve cell apoptosis are the most destructive pathological response after spinal cord injury (SCI). So, suppression combined with neuroprotection is one of promising strategies to treat SCI. Engineered extracellular vesicles anti-inflammatory neuroprotective properties candidates for implementing these treatment SCI.By combining growth factor (NGF) curcumin (Cur), we prepared stable engineered approximately 120 nm from primary M2 macrophages (Cur@EVs-cl-NGF)....
Spinal cord injury (SCI) causes secondary injury, accompanied by pathological changes such as oxidative stress, inflammation and neuronal apoptosis. This leads to permanent disabilities paralysis loss of movement or sensation. Due the ineffectiveness drugs passing through blood spinal barrier (BSCB), there is currently no effective treatment for SCI. The aim this experiment was design plasma complex component functionalized manganese-doped silica nanoparticles (PMMSN) with a redox response...
Spinal cord injury (SCI) is a serious central nervous system disease, and secondary injury, including oxidative stress, the inflammatory response accompanying neuronal apoptosis, will aggravate condition. Due to existence of blood-spinal barrier (BSCB), existing drugs for SCI treatment are difficulty reach site thus their efficacy limited. In this study, we designed chitosan-modified hollow manganese dioxide nanoparticles (CM) delivery resveratrol help it pass through BSCB. Resveratrol...
Spinal cord injury (SCI) causes Ca2+ overload, which can lead to inflammation and neuronal apoptosis. In this study, we prepared a nanovesicle derived from macrophage membrane (MVs), encapsulated sodium alginate (SA) naloxone (NAL) inhibit protect neurons by reducing the free Ca2+concentration at SCI site. Based on transmission electron microscopy (TEM) image, sample (NAL-SA-MVs) had particle size of approximately 134 ± 11 nm exhibited sustained release effect. The encapsulation rate NAL SA...
Stroke is a central nervous system disease with high incidence at present. It can cause pathological changes such as oxidative stress, inflammation, neuronal apoptosis, and lead to disturbance of consciousness, disability, even death. Due the existence blood-brain barrier (BBB), most drugs cannot reach lesions exert their efficacy fully. Therefore, purpose this research was design lactoferrin functionalized hollow mesoporous manganese doped silica nanoparticles (LHMMSN) for delivery...
In this study, we prepared bionic selenium-baicalein nanoparticles (ACM-SSe-BE) for the targeted treatment of nonsmall cell lung cancer. Due to coating A549 membrane, system has homologous targeting capabilities, allowing preparation target tumor cells. The borate ester bond between selenium (SSe) and baicalein (BE) is pH-sensitive can break under acidic conditions in microenvironment achieve release BE at site. Moreover, SSe further enhances antitumor effect by increasing production ROS...
Abstract Ischemic stroke represents a significant global health challenge, frequently associated with intricate pathophysiological alterations. During ischemic stroke, the generation of reactive oxygen species markedly increases, leading to direct neuronal damage as well initiating cascade inflammatory responses. This oxidative stress can also disturb equilibrium gut microbiota, resulting in dysbiosis. In turn, an imbalance microbiota further exacerbate production and contribute...
This paper presents a design method for allocating dimensional tolerances of products with asymmetric quality losses. The strategies proposed include the adjustment manufacturing target and approach robust tolerance design. average losses batch are computed differently in accordance distribution functional characteristics. is based on balance between manufacture cost loss expected. An illustrative example shows procedure helical spring.
In this study, we prepared a C6 cell membrane-coated doxorubicin conjugated manganese dioxide biomimetic nanomedicine system (MnO2-DOX-C6) for the treatment of glioma. glioma microenvironment, could alleviate tumor hypoxia by promoting decomposition hydrogen peroxide (H2O2) to generate oxygen and, through Fenton-like reaction, increase ROS levels in cells, thus inducing oxidative stress further kill cancer cells. Doxorubicin and were connected hydrazone bond so that be released only acidic...
Spinal cord injury is an impact-induced disabling condition. A series of pathological changes after spinal (SCI) are usually associated with oxidative stress, inflammation, and apoptosis. These eventually lead to paralysis. The short half-life low bioavailability many drugs also limit the use in SCI. In this study, we designed nanovesicles derived from macrophages encapsulating selenium nanoparticles (SeNPs) metformin (SeNPs-Met-MVs) be used treatment can cross blood–spinal barrier (BSCB)...
Brain glioma is a highly comorbid tumor with high mortality. In this study, plasma complex component-functionalized manganese-doped mesoporous silica nanoparticles (PMMSN) were prepared and loaded paclitaxel (PTX) by adsorption for brain treatment. The nanodrug delivery system crossed the blood–brain barrier (BBB) exhibited redox responsiveness pH-sensitive release characteristics. vivo imaging revealed ability of preparation to cross BBB, oxidative stress studies properties carrier...
Spinal cord injury (SCI) is an extremely destructive central nervous system lesion. Studies have shown that NGF can promote nerve regeneration after SCI. However, it cannot produce the desired effect due to its stability in body and difficulty passing through blood-brain barrier. In this study, we prepared nanovesicles derived from macrophage membrane encapsulating (NGF-NVs) as a drug carrier for treatment of Cell experiments showed NGF-NVs were effectively taken up by PC12 cells inhibited...