A5101613963- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Sensor and Energy Harvesting Materials
- Luminescence Properties of Advanced Materials
- Magnetism in coordination complexes
- Dermatology and Skin Diseases
- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Crystallography and molecular interactions
- Toxin Mechanisms and Immunotoxins
- Advanced Drug Delivery Systems
- Advanced Chemical Sensor Technologies
- Metal-Organic Frameworks: Synthesis and Applications
- Biosensors and Analytical Detection
- Advanced Condensed Matter Physics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gold and Silver Nanoparticles Synthesis and Applications
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Allergic Rhinitis and Sensitization
- Photodynamic Therapy Research Studies
Xidian University
2019-2025
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2021-2024
Rice University
2020-2024
Jinzhou Medical University
2024
Ministry of Education of the People's Republic of China
2022
Nankai University
2015-2021
Huazhong University of Science and Technology
2017-2019
China XD Group (China)
2019
Wenzhou Medical University
2018
Melanoma is the most aggressive and malignant form of skin cancer. Current melanoma treatment methods generally suffer from frequent drug administration as well difficulty in direct monitoring release. Here, a self-monitoring microneedle (MN)-based delivery system, which integrates dissolving MN patch with aggregation-induced emission (AIE)-active PATC microparticles, designed to achieve light-controlled pulsatile chemo-photothermal synergistic therapy melanoma. The polymeric particles,...
Rapid diagnostic tests are one of the most commonly used to detect and screen for infectious diseases in developing world. While these simple, inexpensive, readily available, they rely on finger-prick blood sampling, which requires trained medical personnel, poses risks infection, can complicate cooperation young children, asymptomatic individuals, communities with taboos. Here, we report a novel microneedle-based skin patch rapid detection protein biomarkers dermal interstitial fluid....
Globally, bladder cancer (BLC) is one of the most common cancers and has a high recurrence mortality rate. Current clinical diagnostic approaches are either invasive or inaccurate. Here, we report on cost-efficient, artificially intelligent chemiresistive sensor array made polyaniline (PANI) derivatives that can noninvasively diagnose BLC at an early stage maintain postoperative surveillance through ″smelling″ urine samples room temperature. In trials, 18 healthy controls 76 patients (60 16...
Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform (ICG-SFNPs) photo-thermal therapy glioblastoma. ICG encapsulated into SFNPs with very high encapsulation efficiency reaching 97.7 ± 1.1%. ICG-SFNPs exhibited spherical morphology...
Abstract Postoperative pain, as a common and significant healthcare issue, has always been the focus of attention in field anesthesia for its control treatment. In present study, pH‐responsive microneedle (MN) patch is developed sustained incisional analgesia after surgery. The MN 10 × array within 0.5 cm 2 area, each features complete core‐shell structure, with needle height ≈850 µm. Upon application, MNs fully implant skin 15 min due to rapid dissolution water‐soluble backing layer. acidic...
Since the triboelectric nanogenerator (TENG) was first reported in 2012, it has attracted much attention because of its simple device design; easy access to environment energy; and wide applications self-powered sensing, biomedicine, smart life. Improving output efficiency working stability is critical for fulfilling potential. material's surface dielectric properties an effective way achieve a high-performance device, metal–organic frameworks (MOFs) with excellent designability...
Interstitial fluid (ISF) contains a wealth of biomolecules, yet it is underutilized for diagnostic testing due to lack rapid and simple techniques collecting abundant amounts fluid. Here, we report minimally invasive technique rapidly sampling larger quantities ISF from human skin. A microneedle array used generate micropores in skin which extracted using vacuum-assisted patch. Using this technique, an average 20.8 μL dermal collected 25 min, ∼6-fold improvement over existing methods....
Abstract Triboelectric nanogenerator (TENG) as an environmental energy recovery and harvesting technology has attracts much attention. However, the improvement of TENG's output performance becomes one core issues. And modification triboelectric materials may be effective approach. Here, two metal–organic framework (MOF) namely TIFSIX‐2‐Cu‐i Cu(Qc) 2 are synthesized, influence different organic ligands on electromechanical conversion TENG is investigated by starting from intrinsic structure...
Liposomes inlaid with tumor cellular membranes may serve as an excellent nanoplatform for homologous-targeting phototherapy using ICG.
Microneedle (MN) patches have become an appealing approach for transdermal drug delivery due to their unique properties, such as enabling self-administration, causing no pain, increasing patient compliance, eliminating biohazardous sharps disposal and avoiding risk of needle-stick injury. Although dissolvable MN achieved great success in bolus the skin, rapidly separable recently attracted strong interest, especially treatment chronic diseases, because short application time, long-acting...
Abstract Microneedles (MNs) have been broadly used for transdermal delivery of a variety drugs, ranging from small chemicals to biological macromolecules, due the properties increased drug permeability, minimal invasiveness and improved patient compliance. Despite these MNs can be made different materials, such as metal, silicon, glass, polymers attracted most attention microneedle (MN) matrix because their excellent biocompatibility biodegradability, which eliminates requirement MN removal...
Peptide-based piezoelectric materials have emerged as a new class of intelligent biomaterials, and applying electric fields during growth was found to result in uniform polarization. Here, we explore in-depth the effect on diphenylalanine peptide crystallization epitaxial growth. The percentage crystals with negative polarization is linearly proportional field strength, while trend slightly different when positive applied. minimum strength needed achieve peptides about 200 kV/m. Due improved...
A large magnetocaloric effect was realized in polymeric 3d complexes for the first time by complementarity of magnetic orbital interactions a heterometallic system.
In this research, a degradable uniform mesoporous platform was designed as an imaging-guided photothermal therapy (PTT)/photodynamic (PDT) agent. Fe3O4 nanoparticles were prepared using the solvothermal method, and layer of SiO2 coated onto them sol-gel etching processes, then these ultra-small up-conversion (UCNPs) loaded into porous structure through electrostatic conjunction physical absorption. By adjusting Fe3O4@mSiO2 mSiO2 with high surface area carrier host could be obtained...
Despite the advances in contraceptives, there is still a high rate of unintended pregnancies worldwide, due large part to lack effective, convenient, and safe birth control methods. Compared with short-acting approaches that offer long-term pregnancy protection have attracted greater interest because reduced dosing frequency improved patient compliance. As novel transdermal drug delivery system, microneedle (MN) patch has been widely used for variety biomedical applications, including...
Brain glioma is a highly comorbid tumor with high mortality. In this study, plasma complex component-functionalized manganese-doped mesoporous silica nanoparticles (PMMSN) were prepared and loaded paclitaxel (PTX) by adsorption for brain treatment. The nanodrug delivery system crossed the blood–brain barrier (BBB) exhibited redox responsiveness pH-sensitive release characteristics. vivo imaging revealed ability of preparation to cross BBB, oxidative stress studies properties carrier...
High glucose level, bacterial infection, and persistent inflammation within the microenvironment are key factors contributing to delay of diabetic ulcers healing, while traditional therapeutic methods generally fail address these issues simultaneously. Here, we present a spatiotemporally responsive cascade bilayer microneedle (MN) patch for accelerating wound healing
In our efforts to fabricate magnetically frustrated materials, a feasible vertices augmentation method was successfully used construct 4-fold interpenetrating three dimensional metal-organic framework (MOF) with rare topology by linking [Fe3(μ3-O)(μ-O2CCH3)6](+) triangular moieties through the pure anti,anti acetate ligands. Strong antiferromagnetic interactions were found exist between neighboring Fe(III) ions without long-range magnetic ordering above 2.2 K, indicating strong geometric...
A lateral flow immunochromatographic assay constructed from a single piece of cellulose paper for rapid analyte detection.
Photoactive theranostics including photodynamic therapy (PDT) hace aroused an intensive interest that combines medical diagnostics with treatment under a single irradiation laser. However, the conventional organic PDT agents usually suffer from aggregation caused by quenching effect. In this research, we designed core–shell–shell (CSS) UCNPs NaGdF4 as host, and could emit higher blue/green light energy transfer processes among Nd/Yb/Tm/Gd/Tb 808 nm When CSS were combined MnO2 semiconductor...