Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally occurring tissues is an eternal pursuit in tissue engineering and stem cell cancer research. However, it remains challenging correlate the of nanomechanics individual building blocks. Here we use single-molecule force spectroscopy, theoretical modeling prove that are predictable based on hierarchy cross-linkers load-bearing modules at molecular level. These findings provide a framework for...

Abstract Hydrogel-based devices are widely used as flexible electronics, biosensors, soft robots, and intelligent human-machine interfaces. In these applications, high stretchability, low hysteresis, anti-fatigue fracture essential but can be rarely met in the same hydrogels simultaneously. Here, we demonstrate a hydrogel design using tandem-repeat proteins cross-linkers random coiled polymers percolating network. Such allows polyprotein only to experience considerable forces at zone unfold...

A strong, tough, and fast-recovery hydrogel is engineered by cooperative interactions between histidine-rich peptides Zn 2+ .

A grating coupler with a high coupling efficiency and low back reflections is designed demonstrated on the thin film lithium niobate platform, which facilitates an efficient interface between ridge waveguide standard single mode fiber. The excellent performances of present are enabled by cavity-assisted structure top metal mirror, even though uniform adopted as diffractive element. Experimentally, loss −0.89 dB at 1552 nm 1-dB bandwidth 45 nm. Low <−16.5 to <−13.7 fiber also...

We report a simple one-step hydrothermal method to fabricate cobalt (Co)-doped vanadium diselenide (VSe2) nanosheets on carbon cloth for the hydrogen evolution reaction (HER) in acid solution. find that Co-doped VSe2 shows significantly enhanced catalytic activity compared with pristine VSe2, including low overpotential of 230 mV at 10 mA/cm2, small Tafel slope 63.4 mV/dec, and high stability. Our density functional theory calculations show Co dopants dramatically reduce Gibbs free energy...

Parameter mismatches seriously impact the stability and rotor-speed accuracy in sensorless induction motor drives, particularly low speed. To deal with parameter sensitivity of drive system an adaptive full-order observer (AFO), this paper proposes a new unified parameter-sensitive equation that could accurately show estimated error caused by all four kinds mismatches—rotor resistance, stator mutual inductance, leakage inductance—with arbitrary feedback gains. With proposed equation, full...

Lithium niobate Mach-Zehnder modulators (MZMs) with compact footprint and fast electro-optics (EO) responses are highly demanded for the next-generation optical interconnect systems. Here, we demonstrate slow-light (SL) effect using a coupled Bragg resonator structure on thin-film lithium (TFLN) platform, an ultra-compact SL-MZM length

With the aim to develop a facile strategy prepare functional drug carriers overcome multidrug resistance (MDR), we prepared heparin/protamine/calcium carbonate (HP/PS/CaCO3) hybrid nanovesicles with enhanced cell internalization, good serum stability, and pH sensitivity for delivery. All components including protamine improve uptake, heparin enhance CaCO3 loading endow system were introduced by self-assembly in an aqueous medium. An antitumor (doxorubicin, DOX) inhibitor (tariquidar, TQR)...

Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform (ICG-SFNPs) photo-thermal therapy glioblastoma. ICG encapsulated into SFNPs with very high encapsulation efficiency reaching 97.7 ± 1.1%. ICG-SFNPs exhibited spherical morphology...

We experimentally demonstrate an integrated visible light modulator at 532 nm on the thin-film lithium niobate platform. The waveguides such platform feature a propagation loss of 2.2 dB/mm while grating for fiber interface has coupling 5 dB. Our fabricated demonstrates low voltage-length product 1.1 V·cm and large electro-optic bandwidth with roll-off -1.59 dB 25 GHz length 3.3 mm. This device offers compact solution to challenge wavelength modulation in paves way future small-form-factor...

Hydrogels, a class of soft materials composed polymer chain network, are widely known to be prone fatigue failure. To understand the underlying mechanisms, we simulate scission...

Osteosarcoma is a typical bone cancer that primarily affects adolescents. The therapeutic activity of drugs limited by their severe drug-related toxicities, therefore, approach which less toxic and highly effective in tumor utmost importance.In this study, ifosfamide-loaded poly (lactic-co-glycolic acid) (PLGA)-dextran polymeric nanoparticles (PD/IFS) was developed studied its anticancer efficacy against multiple osteosarcoma cells. drug-loaded nanoparticle characterized for physical...

Two-dimensional materials have attracted increasing attention because of their particular properties and potential applications in next-generation nanodevices. In this work, we investigate the physical chemical waved graphenes/nanoribbons based on first-principles calculations. We show that graphenes are compressible up to a strain 50% ultra-flexible vanishing in-plane stiffness. The conductivity is reduced due charge decoupling under high compression. Our analysis pyramidalization angles...

Polyhydroxyalkanoates (PHAs) are polyesters accumulated by many bacteria under unbalanced growth conditions, and have been used to meet the various demands in areas of agriculture, medicine, materials especially belong a rapidly expanding area biomedical research. Unfortunately, high production cost than traditional synthetic has greatly limited wide application PHA. Here, we systematically summarized recent progress PHAs series optimization strategies such as supplying renewable carbon...

Estimating extreme value models with high reliability for thermal gradients is a significant task that must be completed before reasonable loads and possible stress in long-span bridges are evaluated. In this article, generalized Pareto distribution–based model combining parameter updating has been developed to describe the statistical characteristics of bridge. The procedure excluding correlation approach selecting proper threshold suggested prepare samples distribution estimation. A...

Abstract The demand of clean energy calls for efficient and low‐cost hydrogen evolution reaction electrocatalysts. Fabricating hybrid catalysts from noble/non‐noble is a practical route to reducing the consumption noble metals enhancing catalytic efficiency. Here, 2H‐MoS 2 etched edge‐doped with Pt nanoparticles using focused ion beam photoreduction techniques. Precise comparison as‐prepared samples demonstrates that enhancement performance can be controlled through tuning catalyst defect...

Synthetic slide-ring hydrogels display excellent mechanical properties, including high extensibility, low viscosity, toughness, etc. Here, by considering molecular frictions induced sliding of rings on polymer chains, we have developed a nonaffine constitutive theory for large stretch behaviors these hydrogels. In the theory, represented volume element cube is employed with one chain aligning along each cubic edge, similar to classical 3-chain model. Different from model, crosslinks at...

A two-dimensional grating coupler for coupling light between a standard single-mode fiber and ridge waveguides on an X-cut lithium niobate thin-film is designed demonstrated. Using circular holes cells, simulated losses reach −3.88 dB at 1550 nm −5.78 1563 with 1-dB bandwidths of 49 45 P-polarized S-polarized inputs, respectively. Experimentally, peak −5.13 1561 −7.6 1568 are obtained respectively, corresponding 1 about 30 nm. An approach to improve the performance also proposed using two...

Abstract Integrated miniature spectrometers have impacts in industry, agriculture, and aerospace applications due to their unique advantages portability energy consumption. Although existing on-chip achieved breakthroughs key performance metrics, such as, a high resolution large bandwidth, scanning speed consumption still hinder practical of devices. Here, stationary Fourier transform spectrometer is introduced based on Mach–Zehnder interferometer structure thin-film lithium niobate. Long...

Instability of silk fibroin nanoparticles (SFNPs) in physiologic condition hinders its application as drug delivery vehicle. Herein, indocyanine green (ICG) loaded (ICG-SFNPs) was firstly prepared and then crosslinked by proanthocyanidins to obtain the stable ICG-CSFNPs for killing residual tumour niche under near infra-red irradiation (NIR) after surgery. The particle size zeta potentials 120.1 nm -40.4 mV, respectively. Moreover, exhibited good stability physiological medium. Meanwhile,...

Background New vessel formation plays a pivotal role in the pathogenesis of neovascular-related diseases. Endothelial progenitor cells (EPCs) were found to contribute diseases and interference with EPC neovascularization may be novel target for these Zoledronate (Zol) was reported exhibit anti-angiogenic effect. Basing on evidences, we proposed that Zol affect function exert In this study, therefore investigated effects multiple aspects explored underlying mechanisms involved....

Polymer network structures can affect the crosslinkers through differential swelling forces acting on crosslinkers, and change dynamic response of hydrogels.

Abstract With lifetime counter-intuitively being prolonged under forces, catch bonds can play critical roles in various sub-cellular processes. By adopting different “catching” strategies within the framework of two-state models, we construct two types that have a similar force-lifetime profile upon constant force-clamp load. However, when single bond either type is subjected to varied find they behave very differently both force history dependence and strength. We further cluster generally...