A5101905625- Angiogenesis and VEGF in Cancer
- Pulmonary Hypertension Research and Treatments
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Atrial Fibrillation Management and Outcomes
- Congenital heart defects research
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Protease and Inhibitor Mechanisms
- Long-Term Effects of COVID-19
- Atherosclerosis and Cardiovascular Diseases
- Coronary Artery Anomalies
- Cardiovascular Effects of Exercise
- Vascular Procedures and Complications
- Eosinophilic Disorders and Syndromes
- Rabies epidemiology and control
- Lymphatic System and Diseases
- Ion Channels and Receptors
- Vascular anomalies and interventions
- Cardiac tumors and thrombi
Zhejiang University
2009-2025
First Affiliated Hospital Zhejiang University
2010-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Zhejiang Chinese Medical University
2015-2020
Centers for Disease Control and Prevention
2012
Henan Provincial Center for Disease Control and Prevention
2012
Tanshinone IIA (Tan IIA) is effective in the treatment of inflammation and atherosclerosis. The adhesion inflammatory cells to vascular endothelium plays important role atherogenic processes. This study examined effects Tan on expression molecules tumor necrosis factor-α (TNF-α)-induced endothelial progenitor (EPCs).EPCs were pretreated with stimulated TNF-α. Mononuclear cell (MNC) assay was performed assess TNF-α-induced MNC adhesion. Expression molecule-1 (VCAM-1)/intracellular (ICAM-1)...
Cardiac hypertrophy is an initiating link to Heart failure (HF) which still seriously endangers human health. Transferrin receptor (TFRC), promotes iron uptake through the transferrin cycle, essential for cardiac function. However, whether TFRC involved in process of pathological not clear.
AimTo evaluate the subclinical cardiac involvement in COVID-19 patients without clinical evidence using MR imaging.Material and methodsParticipants recovered from symptoms no cardiovascular medical history were enrolled a prospective cohort study. They underwent baseline follow-up > 300 days after discharge (n = 20). The study also included healthy controls Extracellular volume fraction (ECV), native T1, 2D strain data assessed compared.ResultsCompared with controls, ECV values of...
Background/Aims: Transplantation of endothelial progenitor cells (EPCs) plays a therapeutic role in pulmonary arterial hypertension (PAH). Meanwhile, recruitment progenitors has potential inflammatory effects and exaggerates vascular injury. CD40 pathway is identified as major player events. In this study, we investigated the regulating early outgrowth EPC functions, searched for improvements PAH cell therapy. Methods: EPCs were isolated from rat bone marrow cultured 7 days. After treatment...
Background New vessel formation plays a pivotal role in the pathogenesis of neovascular-related diseases. Endothelial progenitor cells (EPCs) were found to contribute diseases and interference with EPC neovascularization may be novel target for these Zoledronate (Zol) was reported exhibit anti-angiogenic effect. Basing on evidences, we proposed that Zol affect function exert In this study, therefore investigated effects multiple aspects explored underlying mechanisms involved....
Tanshinone ⅡA (Tan ⅡA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction associated inflammatory processes have critical role development progenitor cells (EPCs) been demonstrated to be involved certain aspects endothelial repair process. The present study aimed investigate putative protective effects Tan on EPCs injured by tumor necrosis factor‑α (TNF‑α)....
Pulmonary artery adventitial fibroblasts, the most abundant cellular constituent of adventitia, are often first to be activated and reprogrammed then influence tone structure vessel wall in pulmonary arterial hypertension (PAH). Our previous study found that interruption CD40 ligand (CD40L)-CD40 signaling improves efficacy transplanted endothelial progenitor cells monocrotaline induced-PAH. However, whether CD40L-CD40 is involved activation fibroblasts PAH Drosophila behavior human splicing...
Abstract During the pathogenesis of early pulmonary arterial hypertension (PAH), adventitial fibroblast act as an initiator and mediator inflammatory processes that predispose vessel walls to excessive vasoconstriction pathogenic vascular remodeling. Emerging studies report Yin Yang‐1 (YY‐1) plays important roles in response injury. Our recent study finds activation CD40 ligand (CD40L)–CD40 signaling promotes pro‐inflammatory phenotype fibroblasts. However, whether YY‐1 is involved...
To assess left atrial (LA) strain parameters using cardiovascular magnetic resonance imaging feature tracking (cardiac MRI-FT) for differentiating hypertensive heart disease (HHD) from hypertrophic cardiomyopathy (HCM), which are two ventricular diseases that could present with similar morphologies in early stage but differ clinical symptoms and treatment strategies. 45 patients HHD, 85 HCM (non-obstructive [HNCM, n = 45] obstructive [HOCM, 40]) 30 healthy controls (HC) were retrospectively...
Interference with endothelial progenitor cell (EPC) neovascularization is a novel therapeutic target for neovascular-related diseases. Angiotensin Ⅱ (Ang Ⅱ) was found to enhance new vessel formation and aggravated In this study, we investigated the effects of Ang on EPC functions explored underlying mechanisms.EPCs were cultured from bone marrow derived mononuclear cells. The proliferation, adhesion, migration, in vitro tube using MTT assay, adhesion transwell chamber assay respectively....
A 61-year-old Chinese man presented with a nearly 30-year history of an anomalous origin the left coronary artery. He had been diagnosed artery in 1989. then underwent regular echocardiographic examinations and it was found that his heart gradually enlarging. After >20-year asymptomatic period, he developed recurrent chest discomfort palpitation. Coronary computed tomography angiography suggested anomaly originated from pulmonary artery; additionally, right tortuous thickened. showed huge...