A5102714237- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- Cardiac Valve Diseases and Treatments
- Central Venous Catheters and Hemodialysis
- Protein Tyrosine Phosphatases
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Venous Thromboembolism Diagnosis and Management
- Kruppel-like factors research
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Eosinophilic Disorders and Syndromes
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Pulmonary Hypertension Research and Treatments
- Autophagy in Disease and Therapy
Shaoxing People's Hospital
2014-2023
Shaoxing University
2006-2023
Zhejiang University
2003-2023
Wenzhou Medical University
2009-2023
University of Fukui
2003-2007
China Medical University
2005
Zhejiang Chinese Medical University
2003
Abstract This newly inaugurated research database for 12-lead electrocardiogram signals was created under the auspices of Chapman University and Shaoxing People’s Hospital (Shaoxing Zhejiang School Medicine) aims to enable scientific community in conducting new studies on arrhythmia other cardiovascular conditions. Certain types arrhythmias, such as atrial fibrillation, have a pronounced negative impact public health, quality life, medical expenditures. As non-invasive test, long term ECG...
Doxorubicin (DOX) is a commonly used chemotherapy drug widely applied in various cancers such as breast cancer, leukemia, and sarcomas. However, its usage limited by cardiotoxicity. Additionally, the cardiac toxicity of DOX accumulates with dose duration, making it imperative to identify therapeutic targets for DOX-induced cardiomyopathy (DIC). It has been reported that miRNAs are involved progression DIC. Mir-34a-5p identified an early diagnostic marker While studies have shown involvement...
Background: Recent studies have revealed that a novel selective sodium-glucose cotransporter 1 (SGLT1) inhibiton has shown beneficial effects in cardiovascular diseases. However, the question of whether SGLT1 inhibition influences diabetic cardiomyopathy (DCM) remains unanswered. In this study, we investigated influence and underlying mechanism SGLTI on DCM. Methods: levels were measured patients with similar conditions who visited our hospital from January to December 2019. Wistar male rats...
The beneficial effect of Chinese rice wine on atherosclerosis has been proved, but the exact components that have cardiovascular protective are still unknown. This study aimed to explore ingredients in could inhibit homocysteine (Hcy)-induced vascular smooth muscle cell (VSMC) proliferation and migration. VSMCs were divided into 7 groups: control, Hcy (1 mmol/L), + oligosaccharide, polypeptides, polyphenols, alcohol, wine. methyl thiazolyl tetrazolium (MTT) assay, Transwell chambers,...
Doxorubicin (DOX) has a wide antitumor spectrum, but its adverse cardiotoxicity may lead to heart failure. Urotensin II (UII) is the most potent vasoconstrictor in mammals. It plays role by activating UII receptor (UT), orphan G protein-coupled (GPR14), collectively referred as UII/UT system. In new version of "Chinese expert consensus on cardiac rehabilitation chronic failure," it pointed out that exercise cornerstone rehabilitation. this study, vitro and vivo assessments were performed...
The tyrosine and phosphoinositide kinases play crucial roles in the regulation of many cancer cell processes including survival motility. Anaplastic thyroid carcinoma (ATC) is a rare deadly type cancer, so far, there are no effective therapeutic compounds for ATC. Herein, we investigate anticancer activities PP121, dual inhibitor kinases, ATC therapy. We found that PP121 at suppressing viability, inducing apoptosis, inhibiting migration invasion. potential mechanism might be its inhibitory...
Summary Aims One potential risk factor for posttraumatic stress disorder ( PTSD ) involves the low activity (short; s) allelic variant of serotonin transporter‐linked polymorphic region (5‐ HTTLPR ), possibly due to reduced prefrontal control over amygdala. Evidence shows that DNA methylation/demethylation is crucial fear extinction in these brain areas and associated with neuronal activation marker c‐Fos expression. We hypothesized impaired transporter knockout HTT −/− rats related changes...
A case of a lost guide wire extending from the vena cava to back neck after central venous catheterization is presented. trainee inserted catheter via left subclavian vein in 40-year-old male patient surgery, but did not notice that was completely vein. After 6 months, seen saphenous through cava, right atrium, ventricle, pulmonary artery and lung tissue neck. Although percutaneous veins routine technique, it procedure requiring advanced surgical skills, expert supervision, attention detail...
Objective: Previous studies have reported that Ras-associated domain family 1A (RASSF1A), the most commonly silenced tumor suppressor via promoter methylation, played vital roles in development of carcinogenesis. The purpose this meta-analysis was to determine whether RASSF1A methylation increased risk thyroid cancer. Methods: PubMed, Embase, ISI Web Knowledge, and Chinese National Knowledge Infrastructure databases were searched obtain eligible studies. pooled odds ratios (ORs) 95%...
Our previous study found that Chinese yellow wine could inhibit the production of homocysteine (HCY) induced extracellular matrix metalloproteinase-2 (MMP-2) in cultured rat vascular smooth muscle cells. Little is known about relationship between and atherosclerosis or MMP-2 vivo. Thirty-two LDL Receptor knockout mice on a high-fat L-methionine diet developed plasma hyperhomocysteinemia atherosclerosis. They were randomly divided into group (n = 8), red ethanol control they sacrificed after...
The phosphatidylinositol-3-kinase/Akt pathway and receptor tyrosine kinases regulate many tumorigenesis related cellular processes including cell metabolism, survival, motility, angiogenesis. Anaplastic thyroid carcinoma (ATC) is a rare type of cancer with no effective systemic therapy. It has been shown that Akt activation associated tumor progression in ATC. Here we observed the additive effect between an inhibitor (MK-2206) novel platelet-derived growth factor (tyrphostin AG 1296) ATC We...
Angiotensin II (Ang II) is reported to be involved in the development of various cardiovascular diseases by disrupting microvessel permeability, however, underlying mechanism remains elucidated. The present study aimed investigate which Ang disrupts microvascular permeability. Rat endothelial cells were subjected primary culture and identification. Cells passages 4‑7 then used for following experiments. divided into control, II, + valsartan groups, reverse transcription‑quantitative...
The aim of this study was to the relationship between plasma homocysteine (Hcy), folic acid, vitamin B12 and early coronary artery disease (early-CAD) high risk factors. Hcy levels 58 cases with early-CAD 31 subjects without CAD were measured using high-performance liquid chromatography (HPLC) fluorescence detection. Plasma acid Vitamin radioassay method. level significantly higher in patients than controls [ (13.7 ± 5.1) μmol/L vs (10.3 5.7) μmol/L]. lower controls. more 3 factors 1 or 2...
A 40 year old man underwent an uncomplicated operation for adhesive intestinal obstruction caused by Crohn’s disease six months previously. After surgery, a cardiologist in his second of training inserted central venous catheter via the left subclavian vein. No problems with catheterisation procedure were recorded. The trainee was …
Objective The objective of this study was to determine similarities in the effect yellow wine as compared statin and possibility that inhibits tumour necrosis factor- α(TNF-α)-induced nitric oxide (NO) synthesis, endothelial synthase (eNOS), inducible (iNOS), intercellular adhesion molecule-1 (ICAM-1) cultured rat vascular cells (VECs).Methods We isolated VECs, cultivated purified Sprague Dawley (SD) thoracic aortas vitro. selected optimal concentration using clonogenic MTT assays measure...