A5021771824- Angiogenesis and VEGF in Cancer
- Lipid metabolism and biosynthesis
- Pulmonary Hypertension Research and Treatments
- Traditional Chinese Medicine Analysis
- Wheat and Barley Genetics and Pathology
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Lipoproteins and Cardiovascular Health
- Immune cells in cancer
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Plant biochemistry and biosynthesis
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Congenital heart defects research
- Eosinophilic Disorders and Syndromes
- Immune Response and Inflammation
- Vascular Anomalies and Treatments
- Cell Adhesion Molecules Research
- Antioxidant Activity and Oxidative Stress
- Cardiac Fibrosis and Remodeling
- Plant Reproductive Biology
- Peroxisome Proliferator-Activated Receptors
- Bone health and treatments
Zhejiang Chinese Medical University
2016-2024
Hebei Agricultural University
2021-2022
Zhejiang University
2012-2016
Tanshinone IIA (Tan IIA) is effective in the treatment of inflammation and atherosclerosis. The adhesion inflammatory cells to vascular endothelium plays important role atherogenic processes. This study examined effects Tan on expression molecules tumor necrosis factor-α (TNF-α)-induced endothelial progenitor (EPCs).EPCs were pretreated with stimulated TNF-α. Mononuclear cell (MNC) assay was performed assess TNF-α-induced MNC adhesion. Expression molecule-1 (VCAM-1)/intracellular (ICAM-1)...
Cancer-associated fibroblasts (CAFs), the most abundant stromal cells in tumor microenvironment (TME), control growth through production and organization of extracellular matrix (ECM) for a long time. However, results from different studies that have focused on targeting CAFs to disturb progression are extremely controversial. Recent using advanced single-cell RNA sequencing technology (scRNAseq) combined with multiple genetically engineered mouse models identified diverse CAF subpopulations...
Cardiac hypertrophy is an initiating link to Heart failure (HF) which still seriously endangers human health. Transferrin receptor (TFRC), promotes iron uptake through the transferrin cycle, essential for cardiac function. However, whether TFRC involved in process of pathological not clear.
Dendritic cells (DCs) have been implicated in the pathogenesis of atherosclerosis (AS). Whereas pathogenic role oxidized low-density lipoprotein (oxLDL) development and progression AS has recognized previously, contribution microRNA-155 (miR-155) to was previously not fully understood. It had also noted that miR-155 levels were upregulated by oxLDL various cell types under different (patho)physiological conditions, but its underlying mechanisms examiend detail. Thus, present study, we...
Background/Aims: Transplantation of endothelial progenitor cells (EPCs) plays a therapeutic role in pulmonary arterial hypertension (PAH). Meanwhile, recruitment progenitors has potential inflammatory effects and exaggerates vascular injury. CD40 pathway is identified as major player events. In this study, we investigated the regulating early outgrowth EPC functions, searched for improvements PAH cell therapy. Methods: EPCs were isolated from rat bone marrow cultured 7 days. After treatment...
Background New vessel formation plays a pivotal role in the pathogenesis of neovascular-related diseases. Endothelial progenitor cells (EPCs) were found to contribute diseases and interference with EPC neovascularization may be novel target for these Zoledronate (Zol) was reported exhibit anti-angiogenic effect. Basing on evidences, we proposed that Zol affect function exert In this study, therefore investigated effects multiple aspects explored underlying mechanisms involved....
Tanshinone ⅡA (Tan ⅡA) is a Traditional Chinese Medicine commonly used in Asian and Western countries for the prevention treatment of cardiovascular disorders, such as atherosclerosis. Endothelial dysfunction associated inflammatory processes have critical role development progenitor cells (EPCs) been demonstrated to be involved certain aspects endothelial repair process. The present study aimed investigate putative protective effects Tan on EPCs injured by tumor necrosis factor‑α (TNF‑α)....
Background: Abnormalities of the mevalonate pathway, an important cellular metabolic are common in many diseases including cardiovascular disease. The pathway related enzyme expressions pressure overload-induced cardiac hypertrophy and associated diastolic dysfunction remains largely unknown. This study aims to investigate whether expression is altered during progression induced by overload. Methods: Male Sprague-Dawley (SD) rats were randomly divided into two groups: suprarenal abdominal...
Oxidized low density lipoprotein (oxLDL)-induced apoptosis of macrophages contributes to the formation atherosclerotic plaques. R‑spondin 2 (Rspo2), a member cysteine‑rich secreted proteins, has been shown be involved in oncogenesis several types cancer. It also found abundantly expressed among four members macrophages. The present study was performed determine whether Rspo2 is ox‑LDL‑induced identified that inhibited oxLDL‑induced presence endoplasmic reticulum (ER) stress activator using...
Pulmonary artery adventitial fibroblasts, the most abundant cellular constituent of adventitia, are often first to be activated and reprogrammed then influence tone structure vessel wall in pulmonary arterial hypertension (PAH). Our previous study found that interruption CD40 ligand (CD40L)-CD40 signaling improves efficacy transplanted endothelial progenitor cells monocrotaline induced-PAH. However, whether CD40L-CD40 is involved activation fibroblasts PAH Drosophila behavior human splicing...
CD97/ADGRE5 protein is predominantly expressed on leukocytes and belongs to the EGF-TM7 receptors family. It mediates granulocytes accumulation in inflammatory tissues involved firm adhesion of PMNC activated endothelial cells. There have not been any studies exploring role CD97 LPS induced NF- κ B activation macrophages. Therefore, we first measured expression treated human primary macrophages subsequently analyzed levels factor TNF- α transcription these that manipulated with either...
Abstract During the pathogenesis of early pulmonary arterial hypertension (PAH), adventitial fibroblast act as an initiator and mediator inflammatory processes that predispose vessel walls to excessive vasoconstriction pathogenic vascular remodeling. Emerging studies report Yin Yang‐1 (YY‐1) plays important roles in response injury. Our recent study finds activation CD40 ligand (CD40L)–CD40 signaling promotes pro‐inflammatory phenotype fibroblasts. However, whether YY‐1 is involved...
Background . Atherosclerosis is an inflammatory cardiovascular disease. However, whether the association of immune cells in plaques promotes progression this disease has not yet been completely elucidated. Materials and Methods Thus, study aimed to investigate relationship between C1q+ macrophages CD8T through scRNA‐seq data reanalysis, quantitative real‐time PCR, flow cytometry. Chromatin immunoprecipitation‐quantitative polymerase chain reaction, western blot, antibody‐blocking experiments...
Interference with endothelial progenitor cell (EPC) neovascularization is a novel therapeutic target for neovascular-related diseases. Angiotensin Ⅱ (Ang Ⅱ) was found to enhance new vessel formation and aggravated In this study, we investigated the effects of Ang on EPC functions explored underlying mechanisms.EPCs were cultured from bone marrow derived mononuclear cells. The proliferation, adhesion, migration, in vitro tube using MTT assay, adhesion transwell chamber assay respectively....
ABSTRACT In cell–cell communication, non-cell-autonomous transcription factors play vital roles in controlling plant stem cell fate. We previously reported that AUXIN RESPONSE FACTOR 3 (ARF3), a member of the ARF family with critical floral meristem maintenance and determinacy, has distinct accumulation pattern differs from expression domain its encoding gene shoot apical (SAM). However, biological meaning this difference is obscure. Here, we demonstrate ARF3 mainly activated at periphery...