A5101613964- Spinal Cord Injury Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Dysraphism and Malformations
- Alzheimer's disease research and treatments
- Electrospun Nanofibers in Biomedical Applications
- Phytoestrogen effects and research
- Prenatal Screening and Diagnostics
- Infant Nutrition and Health
- Nerve Injury and Rehabilitation
- Reproductive Biology and Fertility
- Renal and related cancers
- Ion Transport and Channel Regulation
- Aortic Disease and Treatment Approaches
- GABA and Rice Research
- Adenosine and Purinergic Signaling
- Pregnancy and preeclampsia studies
- RNA Interference and Gene Delivery
- Metabolism and Genetic Disorders
- Body Composition Measurement Techniques
- Congenital Anomalies and Fetal Surgery
- Diabetes Treatment and Management
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Tissue Engineering and Regenerative Medicine
Wenzhou Medical University
2020-2025
Shanghai University of Sport
2025
Jinzhou Medical University
2021-2023
University of Science and Technology of China
2023
Chongqing Medical University
2021-2022
Nankai University
2019-2020
Nanjing Children's Hospital
2014
Nanjing Medical University
2014
Spinal cord injury (SCI) causes secondary injury, accompanied by pathological changes such as oxidative stress, inflammation and neuronal apoptosis. This leads to permanent disabilities paralysis loss of movement or sensation. Due the ineffectiveness drugs passing through blood spinal barrier (BSCB), there is currently no effective treatment for SCI. The aim this experiment was design plasma complex component functionalized manganese-doped silica nanoparticles (PMMSN) with a redox response...
Spinal cord injury (SCI) causes Ca2+ overload, which can lead to inflammation and neuronal apoptosis. In this study, we prepared a nanovesicle derived from macrophage membrane (MVs), encapsulated sodium alginate (SA) naloxone (NAL) inhibit protect neurons by reducing the free Ca2+concentration at SCI site. Based on transmission electron microscopy (TEM) image, sample (NAL-SA-MVs) had particle size of approximately 134 ± 11 nm exhibited sustained release effect. The encapsulation rate NAL SA...
The recovery of spinal cord injury (SCI) is closely associated with the obstruction oligodendrocyte progenitor cell (OPC) differentiation, which ultimately induces inability to generate newly formed myelin. To address concern, drug-based methods may be most practical and feasible way, possibly applying clinical therapies for patients SCI. In our previous study, we found that clemastine treatment preserves myelin integrity, decreases loss axons, improves functional in SCI model. Clemastine...
Abstract Recent evidence has shown that demyelination occurs along with axonal degeneration in spinal cord injury (SCI) during the secondary phase. Oligodendrocyte precursor cells (OPC) are present lesions but fail to differentiate into mature oligodendrocytes and form new myelin. Given limited recovery of neuronal functions after SCI adults without effective treatment available so far, it remains unknown whether enhancing OPC differentiation myelination could benefit SCI. To show...
Islet transplantation is considered a potential therapeutic option to reverse diabetes. The pancreatic basement membrane contains variety of extracellular matrix (ECM) proteins. abundant ECM essential for the survival transplanted islets. However, proteins necessary maintaining islet vascularization and innervation are impaired by enzymatic digestion in isolation process before transplantation, leading destruction microvessels. These primary concern major barrier long-term function. Thus, it...
As a novel guanylate cyclase stimulator, SGC003F is being developed for the treatment of heart failure with reduced ejection fraction (HFrEF). This study aimed to assess effect P-glycoprotein (P-gp) inhibition on exposure in vivo, comparing plasma and tissue levels, evaluating role P-gp small intestine, blood-brain barrier (BBB), kidney impacting exposure. Tariquidar, inhibitor, was added monolayer transport assays observe changes transmembrane characteristics SGC003F. Rats were given...
Secondary injury following spinal cord (SCI) results in a large production of reactive oxygen species (ROS) (e.g., H2O2) the microenvironment, which then leads to an excessive burst inflammation and ultimately neuronal death. In this study, we prepared manganese dioxide (MnO2) nanoparticles coated by macrophage membranes, named M@MnO2, cope with early ROS bursts SCI microenvironment. The biosafety targeting ability MnO2 were improved through membranes. Successful preparation M@MnO2 was...
Abstract Objectives This study aimed to clarify the prevalence and associated factors of lower back pain (LBP) in sarcopenia population aged 45 years or older by using a large diverse cross-sectional dataset. Methods In this national study, data on 8113 participants from CHARLS 2015 were analyzed. The LBP was investigated, multivariable logistic regression analyses performed identify with population. Findings: 24.19% (95% CI 22.94–25.44) population, significantly higher than that...
Objective To explore the expression levels of immune-related microRNA-146b(miR-146b), microRNA-155(miR-155) and microRNA-30b(miR-30b) in human breast milk its relationship with maternal infant's health. Methods One hundred thirty-four mothers their infants from obstetrical department were recruited study after delivery.The subjects divided into 2 groups, feeding group(n=86) formula-fee-ding group(n=48), followed up 3 months delivery.Breast samples collected at 2-5 days...
Abstract Human oocyte maturation arrest represents one of the severe conditions for female patients with primary infertility. However, genetic factors underlying this human disease remain largely unknown. The spindle assembly checkpoint (SAC) is an intricate surveillance mechanism that ensures accurate segregation chromosomes throughout cell cycles. Once kinetochores are correctly attached to bipolar spindles and SAC satisfied, MAD2L1BP, best known as p31 comet , binds MAD2 recruits...