Abstract: Naringenin (NRG), a flavonoid compound, had been reported to exhibit extensive pharmacological effects, but its water solubility and oral bioavailability are only ~46±6 µg/mL 5.8%, respectively. The purpose of this study is design develop NRG-loaded solid lipid nanoparticles (NRG-SLNs) provide prolonged sustained drug release, with improved stability, involving nontoxic nanocarriers, increase the by means pulmonary administration. Initially, group contribution method was used...

Allopurinol is a xanthine oxidase inhibitor with poor solubility and permeability, which severely limit its drug absorption following the administration of some dosage forms, such as tablets rectal suppositories. To improve physicochemical properties, three cocrystals allopurinol isonicotinamide (ALP-INA), piperazine (ALP-PIP), 2,4-dihydroxybenzoic acid (ALP-24DHBZA) were successfully prepared by slurry or liquid-assisted grinding method. The obtained cocrystal materials characterized...

In this study, we developed a lipid-coated hollow calcium phosphate (LCP) nanoparticle for the combined application of two chemotherapeutic drugs to human lung cancer A549 cells. Hydrophilic doxorubicin (DOX) was incorporated into structure (HCP), and lipid bilayer containing hydrophobic paclitaxel (PTX) subsequently coated on surface HCP. The study combinational effects demonstrated that combination DOX PTX at mass ratio 12:1 showed synergistic effect against particle size, zeta potential,...

A biodegradable alginate coated chitosan hollow nanosphere (ACHN) was prepared by a hard template method and used for codelivery of doxorubicin (DOX) paclitaxel (PTX) to investigate the effect on human lung cancer A549 cells. PTX loaded into nanometer structure ACHN through adsorption method. DOX surface electrostatic interaction. Drug release studies exhibited sustained-release effect. According X-ray diffraction patterns (XRD), differential scanning calorimetry (DSC), Fourier transform...

In this paper, we prepared doxorubicin-loaded folic acid-functionalized pH-sensitive photothermal therapy (PTT) traceable hollow mesoporous silica nanoparticles (DOX-HPCF) as a drug carrier for liver cancer treatment. According to TEM characterization, (HMSN) are monodispersed spherical particles with structure. vitro release experiments showed that HPCF exhibited release. Cell uptake was successfully absorbed by SMMC-7721 cells. addition, DOX-HPCF significantly inhibited the proliferation...

In this study, biodegradable chitosan hollow nanospheres (CHN) were fabricated using polystyrene (PS) as templates. CHN applied to increase the solubility of poorly water-soluble drugs. The lung cancer drug paclitaxel (PTX), which is used a model drug, was loaded into by adsorption equilibrium method. drug-loaded sample (PTX-CHN) offered sustained PTX release and good bioavailability. state characterization differential scanning calorimetry (DSC), X-ray diffraction (XRD) Fourier transform...

The solubility and pharmacokinetic properties of 5-fluorouracil were modified by cocrystallization with dihydroxybenzoic acids.

Three cocrystals of axitinib were prepared, and they demonstrated a significantly improved apparent solubility dissolution rate without compromising physical stability.

The aim of this study was to design a chitosan-coated hollow tin dioxide nanosphere (CS-HSn) for loading febuxostat (FEB) using an adsorption method obtain sustained-release system (CS-HSn-FEB) improve the oral bioavailability FEB. morphological characteristics nanospheres (HSn) and CS-HSn were analyzed by transmission electron microscopy (TEM) dynamic light scattering (DLS). hemolysis test CCK-8 used assess biosafety HSn CS-HSn. Powder X-ray diffraction (PXRD) differential scanning thermal...

Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy Lingling Shan,1 Ming Liu,2 Chao Wu,1 Liang Zhao,1 Siwen Li,3 Lisheng Xu,1 Wengen Cao,1 Guizhen Gao,1 Yueqing Gu3 1Institute of Pharmaceutical Biotechnology, School Biology and Food Engineering, Suzhou University, Suzhou, People's Republic China; 2Department Biology, University South Dakota, Vermillion, SD, USA; 3Department Biomedical Life Science Technology, China Nanjing, Abstract: In response to the...

The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments in vivo antitumor efficacy demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared pure PTX mesoporous (MSNs-PTX). biodistribution investigation nude mice revealed the could accumulate tumors. Folic acid...

Starch macrocellular foam (SMF), a novel natural bio-matrix material, was prepared by the hard template method in order to improve dissolution rate and oral bioavailability of poorly water-soluble drugs. Nitrendipine (NDP) chosen as model drug loaded into SMF solvent evaporation method. samples (NDP-SMF) were characterized scanning electron microscopy, differential calorimetry, X-ray powder diffraction Fourier transform infrared spectroscopy. In vitro release studies showed that...

Abstract The hedgehog (Hh) signaling pathway is known to be essential for multiple aspects of embryonic development, and activation the Hh leads development several human malignancies such as basal cell carcinoma medulloblastoma. Recent data have implicated a much broader role in other cancer well maintenance stem cells. Loss-function mutation Ptc gain gunction Smo make components attractive therapeutic targets. However, this readily deactivated once tumor cells are propagated culture,...

With the rapid growth of military medium and heavy UAV(Unmanned Aerial Vehicle) equipment, steady prolongation training/operation time, gradual enrichment operation mode, UAV is facing many practical challenges, such as high system complexity, fast update new technology, development anti-UAV defense etc. The number accidents equipment increasing, reliability safety problems are increasing obviously. In this paper, latest foreign UAVs in past 10 years analyzed. Combined with performance...

Three new salts of rucaparib with fumaric acid, adipic acid and pimelic were synthesized characterized, the latter two demonstrate significantly improved solubility without sacrificing hygroscopicity physical stability.