A5028706121- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cerebrovascular and Carotid Artery Diseases
- Hip disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Bone and Joint Diseases
- Lung Cancer Treatments and Mutations
- Bone health and treatments
- Orthopedic Infections and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Vascular Malformations and Hemangiomas
- Metastasis and carcinoma case studies
- Estrogen and related hormone effects
- Peptidase Inhibition and Analysis
Xinjiang Medical University
2024-2025
Sixth Affiliated Hospital of Xinjiang Medical University
2024
Hebei General Hospital
2023
Clinical Trial Investigators
2022
Nantong University
2011-2021
Tongji University
2021
Affiliated Hospital of Nantong University
2011-2021
Yancheng First People's Hospital
2013-2021
Beijing YouAn Hospital
2018-2020
Capital Medical University
2018-2020
<h3>Importance</h3> In-stent restenosis (ISR) is the primary reason for stroke recurrence after intracranial stenting in patients who were treated with a standard bare-metal stent (BMS). Whether drug-eluting (DES) could reduce risk of ISR atherosclerotic stenosis (ICAS) remains unclear. <h3>Objective</h3> To investigate whether DES can and symptomatic high-grade ICAS. <h3>Design, Settings, Participants</h3> A prospective, multicenter, open-label randomized clinical trial blinded outcome...
Hoxa-10 is an AbdominalB-like homeobox gene that expressed in the developing genitourinary tract during embryogenesis and adult uterus early pregnancy. Null mutation of mouse causes both male female infertility. Defective implantation decidualization resulting from loss maternal function uterine stromal cells cause However, mechanisms by which regulates these events are unknown. We have identified two potential for defects Hoxa-10(−/−) mice. First, PGE2 receptor subtypes, EP3 EP4, aberrantly...
Osteoporotic vertebral fractures and their complications pose increasing risks to the elderly. The purpose of this study was evaluate clinical efficacy unilateral percutaneous vertebroplasty in patients with osteoporotic compression (OVCF) by assessing postoperative cement distribution. This aimed investigate impact distribution on fracture repair provide effective preventive therapeutic measures, prevent re-fracture, improve surgical outcomes. A total 170 who underwent at our hospital from...
Heat shock proteins (HSPs), which are molecular chaperones that stabilize numerous vital proteins, may be attractive targets for cancer therapy. The aim of the present study was to investigate possible anticancer effect single or dual targeting HSP90 and HSP70 combination treatment with HSP inhibitors chemotherapeutic agents in bladder cells. expression inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) coupled cisplatin, docetaxel, gemcitabine were examined using...
Cognitive impairment is a prevalent but underestimated complication of diabetes, which can cause spatial memory and learning deficits. In the present study, streptozotocin-induced type 2 diabetic rat model was employed to investigate effects vildagliptin, new oral hypoglycemic agent that acts by inhibiting dipeptidyl peptidase-4, on diabetes-associated cognitive impairments, as well molecular mechanisms involved. The findings demonstrated vildagliptin treatment prevented decreased apoptosis...
Primary hepatic sarcomatous carcinoma (PHSC) is a rare malignancy composed of both carcinomatous (either hepatocellular or cholangiocellular) and components. The purpose our study was to evaluate the imaging clinical findings PHSCs, improving understanding diagnosis tumors. We retrospectively reviewed ten patients with pathologically proven including two cases intrahepatic cholangiocarcinoma (S-ICC), seven (S-HCC) one case combined (S-HCC–CC). Six underwent computed tomography (CT) scans...
Gene expression profiles of gastric cancer (GC) were analyzed with bioinformatics tools to identify signature genes associated prognosis. Four gene data sets (accession number: GSE2685, GSE30727, GSE38932 and GSE26253) downloaded from Expression Omnibus. Differentially expressed (DEGs) screened out using significance analysis microarrays (SAM) algorithm. P-value 1 set as the threshold. A co-expression network was constructed for GC-related package WGCNA R. Modules disclosed Survival-related...
To assess the benefits of use a tourniquet in one limb patients undergoing simultaneous bilateral total knee arthroplasty (TKA).A prospective randomized trial was designed to evaluate outcomes unilateral during TKA. A 52 (36 women and 16 men) with osteoarthritis who underwent primary TKA between January 2010 2015 were assigned randomly (TG) or non-tourniquet (NG) groups prior surgery. Operating time, pain score, range motion, first active straight-leg raise swelling, wound healing, deep vein...
Hepatocellular carcinoma (HCC) often has an insidious onset and rapid progression. Often, when the disease is first diagnosed, opportune time for surgical intervention already lapsed. In addition, effects of systemic treatment relatively unsatisfactory. Metabolic reprogramming one hallmarks cancer. This study aimed to identify a set genes related metabolism construct predictive model prognosis HCC.The transcriptomic clinical data 352 HCC patients were obtained from The Cancer Genome Atlas...
Despite the great efforts for tumor therapy in last decades, currently chemotherapy induced toxicity remains a formidable problem cancer patients, and it usually prohibits from successful completion due to severe side effects. In general, main effects of chemotherapeutic agents are as-produced reactive oxygen species (ROS) that not only harm cells but also damage patients' organs. Here we report application amino acid derivatives fullerene (AADF) which strongly scavenge excess ROS protect...
The histamine H3 receptor (HRH3) is mainly expressed in areas of the brain involved regulation release various neurotransmitters. Recent studies have shown that HRH3 expression increased several types carcinomas. However, functional roles and underlying molecular mechanism by which regulates cell survival hepatocellular carcinoma (HCC) remain unknown.The mRNA protein level target genes were evaluated qRT-PCR, Western blot immunohistochemistry, respectively. Cell viability proliferation...
Pathogenesis of lung cancer is a complicated biological process including multiple genetic and epigenetic changes. Since cigarette smoking confirmed as the most main risk factor non-small cell (NSCLC), aim this study was to determine whether tobacco exposure plays role in gene methylation. Methylation RAR-<TEX>${\beta}$</TEX> were detected using methylation-specific polymerase chain reaction DNA from 167 newly diagnosed cases with NSCLC corresponding 105 controls. A significant statistical...
Abstract The root of Paeonia lactiflora Pall. (Chishao, CS) and Ligusticum chuanxiong Hort. (Chuanxiong, CX) were widely used as a drug pair in Chinese Medicine, the combination CS CX showed more significant inhibition on neuronal apoptosis our previous study. In present study, total paeony glycosides (TPGs) from ligustici phenolic acids (TLPAs) combined to evaluate synergistic effects against focal cerebral ischemia both vitro vivo . TPGs TLPAs at 7:3 had best anti-oxidative stress...
Purpose To investigate the efficacy of percutaneous thermal ablation combined with transarterial chemoembolization (TACE) versus TACE monotherapy in treating primary liver cancer hepatic vein tumor thrombus (HVTT), and to identify potential factors overall survival after combination therapy. Materials methods Patients HVTT from 2011 2016 at our institute were retrospectively identified. They divided into two groups (group A group B). underwent subsequent ablation, while patients B who...
Our study aimed to investigate effect of expressions tumor necrosis factor α (TNF-α) and interleukin 1B (IL-1B) on peritoneal metastasis gastric cancer (GC). From June 2012 2014, a total 60 patients with advanced from GC were collected Department Gastrointestinal Nutriology Surgery at Shengjing Hospital China Medical University. Furthermore, without enrolled as controls. Immunohistochemistry was performed test TNF-α IL-1B expression, logistic regression analysis employed for evaluating risk...
Abstract Background Primary hepatic sarcomatous carcinoma (PHSC) and primary sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic radiology. No comparative study of these tumors for restricted cases has previously been undertaken. The purpose our was to analyze clinical imaging features PHSCs PHSs, an emphasis on particularities similarities through a comparison two tumors. Methods We retrospectively analyzed 39 patients pathologically proven ( n = 23) PHSs 16) from...
Aim: This study aimed to investigate the safety and efficacy of combination therapy transcatheter arterial chemoembolization (TACE) CT-guided percutaneous partial hepatic segment ablation. Material methods: Liver cancer patients undergoing TACE plus ablation from 2012 2016 were retrospectively analyzed. Patient characteristics collected. was performed for all before After ablation, CT imagings used evaluate treatment follow-up. Overall survival (OS) local tumor progression free (LTPFS)...
Background: This study aimed to identify any association between the p73 gene G4C14-to-A4T14 polymorphism and risk of non-small cell lung cancer (NSCLC) in south China. Materials Methods: We genotyped peripheral blood DNA from 168 patients with NSCLC 195 normal controls using HRM (high resolution melting) PCR-CTPP (polymerase chain reaction confronting two-pair primers). Results: The results genotyping by were consistent direct sequencing, genotype distribution being as follows: GC/GC 101...