A5101511103- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Cell death mechanisms and regulation
- Peroxisome Proliferator-Activated Receptors
- Cancer therapeutics and mechanisms
- Multiple Myeloma Research and Treatments
- Biopolymer Synthesis and Applications
- Autoimmune and Inflammatory Disorders Research
- Mangiferin and Mango Extracts
- Ferroptosis and cancer prognosis
- Regulation of Appetite and Obesity
- Vascular Tumors and Angiosarcomas
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Lung Cancer Research Studies
- Lymphatic System and Diseases
Nanjing Medical University
2017-2022
Nanjing Chest Hospital
2022
Nanjing Brain Hospital
2022
University of South China
2019-2021
First Affiliated Hospital of University of South China
2019-2021
Nanjing University of Chinese Medicine
2019-2021
Huaian First People’s Hospital
2021
Nantong University
2013-2020
Yancheng First People's Hospital
2013-2020
Affiliated Hospital of Nantong University
2018-2020
Over the past several years, long non‐coding RNAs (lncRNAs) have attracted more and attention due to their special functions. They are vital biomarkers in multiple diseases. LncRNA HOMEOBOX A11 (HOXA11) has been found be aberrantly expressed some kinds of malignant tumors. In this study, we mainly discuss oncogenic role it promoting progression chemoresistance lung adenocarcinoma (LUAD) cells. The expression HOXA11‐AS was much stronger cisplatin‐resistant LUAD Based on Cancer Genome Atlas...
Increasing studies showed that kinesin family member 20A (KIF20A) was overexpessed in several types of cancer, and its overexpression correlated with the oncogenesis prognosis cancers. However, little is known about role KIF20A lung adenocarcinoma (LUAD). In this study, we employed bioinformatics analysis to identify upregulation LUAD, then verified results human tumor specimens LUAD cell lines. Compared normal tissues, a ubiquitous observed tissues by immunohistochemistry (IHC) as well TCGA...
Abstract Increasing studies show that circular RNAs (circRNAs) play vital roles in tumour progression. But, how circRNAs function ovarian cancer is mostly unclear. Here, we detected the expression of circEPSTI1 and explored via a series experiments. Then, performed luciferase assay RNA immunoprecipitation (RIP) to explore competing endogenous (ceRNA) cancer. qRT‐PCR verified was overexpressed Inhibition suppressed cell proliferation, invasion but promoted apoptosis. Luciferase assays RIP...
Circular RNAs (circRNAs), a novel type of endogenous noncoding RNAs, have been identified as critical regulators in human carcinogenesis. Here, we investigated the precise actions hsa_circ_0009035 progression and radioresistance cervical cancer (CC). The levels hsa_circ_0009035, microRNA 889-3p (miR-889-3p), homeobox B7 (HOXB7) were detected by quantitative real-time PCR (qRT-PCR) or Western blotting. RNase R actinomycin D assays used to assess stability hsa_circ_0009035. Cell proliferation,...
Previous studies have shown that ovariectomy (OVX) induces lacrimal gland regression and androgens are implicated. This study explored the effects of estrogen androgen on tear secretion matrix metalloproteinase 2 (MMP-2) expression in glands ovariectomized rats.Sixty-four adult female Wistar rats were randomly divided into three groups (control, sham operated, OVX). Bilateral OVX was performed group. After 5 months, group further six subgroups receiving topical ophthalmic or systemic...
BACKGROUND Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in human cancers, including ovarian cancer. Several reports identified lncRNA FEZF1-AS1 an oncogene gastric cancer, colorectal carcinoma, and non-small cell lung cancer (NSCLC). However, the function of remains largely unknown. This study was aimed to investigate role MATERIAL AND METHODS expression levels pairs tissues adjacent normal were measured by quantitative real-time polymerase chain reaction...
Backgroud: Increasing studies show that circular RNAs (circRNAs) play important roles in tumor progression. However, the function of circRNAs ovarian cancer is mostly unclear. Methods: We detected expression circGFRA1 by quantitative real-time PCR (qRT-PCR) 50 pairs tissues and adjacent normal tissues. Then, we explored progression, such as cell proliferation, apoptosis invasion. Moreover, performed luciferase reporter RNA immunoprecipitation (RIP) assay to study competing endogenous (ceRNA)...
Abstract The development of acquired EGFR ‐ TKI therapeutic resistance is still a serious clinical problem in the management lung adenocarcinoma. Peroxisome proliferator activated receptor gamma ( PPAR γ ) agonists may exhibit anti‐tumor activity by transactivating genes which are closely associated with cell proliferation, apoptosis, and differentiation. However, it remains not clear whether efatutazone has similar roles adenocarcinoma cells gefitinib resistant such as HCC 827‐ GR PC 9‐ ....
The present study aimed to investigate the role of apigenin and molecular mechanism miR-152-5p bromodomain containing 4 (BRD4) in proliferation, invasion, epithelial-mesenchymal transition (EMT) cervical carcinoma cells. Quantitative real-time PCR was used detect transfection efficiency expression BRD4. Western blotting conducted evaluate protein level BRD4, E-cadherin, N-cadherin, MMP9. Luciferase reporter assay performed confirm whether bound MTT Transwell invasion were applied determine...
The current study aimed to investigate the interrelation between P2RY14 and prognosis of patients suffering from lung adenocarcinoma (LUAD) following surgery.The differentially expressed gene (DEG) was screened by Gene Expression Omnibus (GEO), Cancer Genome Atlas (TCGA), Immunology Database Analysis Portal (ImmPort) databases. relationship clinical data LUAD analyzed in TCGA Kaplan-Meier (KM)-plotter association with immune cells immune-related genes Tumor Immune Estimation Resource (TIMER)...
In this study, we inhibited the expression of VEGF by short hairpin RNA (shRNA) in SKOV3 ovarian cancer cells vitro and vivo to explore antitumor efficacy shRNA cells.ShRNA targeting was cloned into pGenesil-2 plasmid vector then transfected using liposome. Silencing measured RT-PCR ELISA assays. Furthermore, growth inhibition capacity on intraperitoneal carcinomatosis tested nude mice. Tumor weight measured. Microvessel density, number apoptotic proliferation index tumor tissues were...
The growth and persistence of solid tumors their metastases are angiogenesis dependent. Targeting represents a new strategy for the development antitumor therapies. extracellular immunoglobulin- like domain VEGFR-2 (KDR/Flk-1), soluble VEGFR-2, may form heterodimeric complex with wild-type VEGF receptor function as dominant negative receptor. We assessed effects sFlk-1 on SKOV3 cell proliferation in vitro. Furthermore, we investigated effectiveness recombinant Flk-1 adenovirus inhibition...
Gu-Ben-Fang-Xiao decoction (GBFXD), derived from the traditional Chinese medicine Yu-Ping-Feng-San, is widely used in clinical settings and has obvious curative effects respiratory diseases. GBFXD regulates cholesterol transport lipid metabolism chronic persistent asthma. There evidence for its beneficial remission stage of asthma; however, metabolic regulatory underlying mechanisms during asthma are unclear. In present study, we liquid chromatography-mass spectrometry (LC-MS) to analyse...
BACKGROUND:Reducing drug resistance in tumor cells has become an important issue for cancer treatment. The purpose of this study was to investigate whether IL-22 involved lung cell paclitaxel (PTX), and explore the underlying molecular mechanism. MATERIAL AND METHODS:Non-small (NSCLC) line A549 resistant A549/PTX were used present study. inhibitory rate PTX on proliferation determined by MTT assay half-maximal concentration (IC50) value calculated. expression level detected using Western...
G protein γ subunit 7 (GNG7) is a of heterotrimeric protein. It has been demonstrated low expressed GNG7 in various cancers. Nevertheless, the role lung adenocarcinoma (LUAD) remains unclear. In present study, expression LUAD tissues and cell lines was analyzed by RT-qPCR, western blot immunohistochemical. Kaplan-Meier analysis performed for determining prognostic value expression. Then, function progression examined proliferation, invasion mouse xenograft assays. addition, underlying...
Background: A long non-coding RNA termed as intergenic non-protein coding 491 (LINC00491) has been validated an oncogene to promote cancer progression in colon adenocarcinoma. The goal of this study was determine the expression and carcinogenic functions LINC00491 non-small-cell lung (NSCLC). Besides, it aimed understand how affects malignant processes NSCLC cells. Methods: investigated by bioinformatic analysis reverse transcription-quantitative PCR. After knockdown, cell counting kit-8...