A5089544140- Glutathione Transferases and Polymorphisms
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Quinazolinone synthesis and applications
- CAR-T cell therapy research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Neuroblastoma Research and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cholesterol and Lipid Metabolism
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Carbohydrate Chemistry and Synthesis
Qingdao Municipal Hospital
2022
Shandong First Medical University
2022
Qingdao University
2022
Jiangsu Cancer Hospital
2017-2021
Nanjing Medical University
2017-2021
Second Affiliated Hospital of Nanjing Medical University
2018
Abstract Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose opportunity surgical therapy, most whom fail to reach good prognosis after chemotherapy. Recently, a few clinical studies have confirmed role adoptive T-cell transfer in maintenance therapy patients. Here, we provided statistical insights into CIKs from three different levels, cell model (in vitro co-culture system), mice situ cancer), research progression stages). We optimized components...
Liver X receptors are recognized as important regulators of cholesterol, fatty acid metabolism, inflammatory responses, and glucose homeostasis. The antineoplastic properties synthetic liver receptor (LXR) agonists (T0901317 GW3965) have been reported in human carcinomas. Epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI) is a first-line treatment for non-small-cell lung cancer patients with EGFR mutations. We used scratch transwell assays to analyze cell migration invasion....
Abstract Colorectal cancer (CRC) is characterized by DNA methylation, which associated with genomic instability and tumor initiation. As an important epigenetic regulation, methylation can be used as a potential therapeutic target for CRC. In our study, we downloaded profiles (GSE17648 GSE29490) RNA sequencing microarray data (GSE25070 GSE32323) from the Gene Expression Omnibus (GEO) database. result, 14 aberrantly methylated differentially expressed genes (DEGs) were screened according to...
Abstract Chimeric antigen receptor T-cell immunotherapy (CAR-T) has shown remarkable efficacy in treating tumors of lymphopoietic origin. Herein, we demonstrate an effective CAR-T cell treatment for recurrent and malignant CD30-positive peripheral lymphomas (PTCL) been demonstrated. The extracellular fragment gene sequences CD30 were obtained from tumor tissues PTCL patients cloned into a plasmid vector to express the antigen. targeting single-chain antibody (scFv) was monoclonal hybridoma...
The N-acetylneuraminic acid−α(2–3)-galactose epitope is often located at the nonreducing terminal ends of glycans on envelopes many pathogens, and it believed that this structure mimics a host's oligosaccharide so as to circumvent and/or counteract immune responses. A chemoenzymatic method for rapid sensitive detection has been built, we planned examine whether could be applied pathogens. Our results revealed was labeling live or dead Gram-positive Streptococcus agalactiae A909 Gram-negative...
Gefitinib, a first-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), is recommended for treatment of non-small cell lung cancer (NSCLC) patients who harbor activating mutations.However, the tumors most initially sensitive to gefitinib will develop resistance within several months therapy.Drug major obstacle NSCLC treatment.The novel glutathione transferase P1 (GSTPi) 6-(7-nitro-2, 1, 3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) has recently been shown be active against tumors.In this...