A5100618937- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Vibrio bacteria research studies
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Genital Health and Disease
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Cellular Mechanics and Interactions
- Pediatric health and respiratory diseases
- Hippo pathway signaling and YAP/TAZ
- Listeria monocytogenes in Food Safety
- Circular RNAs in diseases
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- Heat shock proteins research
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Autoimmune and Inflammatory Disorders Research
- CAR-T cell therapy research
- Endoplasmic Reticulum Stress and Disease
- Microtubule and mitosis dynamics
Chongqing Medical and Pharmaceutical College
2024
Chongqing University
2018-2021
Nanjing Medical University
2018
Jiangsu Cancer Hospital
2018
Integrated Chinese Medicine (China)
2010
Qingdao University
2010
Columbia University
2009
University of California, Los Angeles
2002
Black AIDS Institute
2002
Abstract Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose opportunity surgical therapy, most whom fail to reach good prognosis after chemotherapy. Recently, a few clinical studies have confirmed role adoptive T-cell transfer in maintenance therapy patients. Here, we provided statistical insights into CIKs from three different levels, cell model (in vitro co-culture system), mice situ cancer), research progression stages). We optimized components...
Influenza affects most of the world's population annually, often causing a secondary infection, but pathological mechanisms influenza virus infection remain unclear. We have found that viruses selective preference for infecting monocytes and mature immune effector cells. This paper provides evidence increases expression granzyme B (GrB) in monocytes, activated T All GrB+ cells had cytolytic function. GrB+CD62Lhigh central memory (TCM) were fast response to when compared with GrB+CD62Llow...
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival Listeria monocytogenes The complex spatiotemporal regulation bacterial by various has been challenging to study. Here, using mass spectrometry analyses, we depicted dynamic expression landscape upon L. in dendritic cells. We showed that Dynein light chain 1 (Dynll1) formed persistent with mitochondrial cytochrome oxidase Cox4i1, which is disturbed pathogen insult....
Infection of CD4- cells by HIV-1 is well documented, but the mechanism responsible remains a matter discussion. Previously we modified an virus strain, NL4-3, deleting Env proteins (gp41 and gp120) inserting enhanced green fluorescent protein (EGFP), found that Env(-) infects several types cells. Here, have prepared from both cell line, 293T, CD4+ lines, CEM SUPT1, either type infectious for lines. Replication virus-infected was demonstrated p24 gag assays real-time reverse transcriptase...
Abstract Tumor-infiltrating lymphocytes (TILs) play a key role in regulating the host immune response and shaping tumor microenvironment. It has been previously shown that T cell infiltration penile tumors was associated with clinical outcomes. However, few studies have reported receptor (TCR) repertoire patients cancer. In present study, we evaluated TCR repertoires adjacent normal tissues from 22 squamous carcinoma (PSCC). Analysis of beta-variable (TRBV) joining (TRBJ) genes usage...
Abstract Capillary morphogenesis protein 2 (CMG2) was originally identified through its participation in capillary morphogenesis, and subsequently as the second receptor for anthrax toxin (ANTXR2). Although tumor‐associated functions of CMG2 have also been reported, clinical significance functional mechanism glioma remain to be elucidated. We assessed clinicopathological relevance a cohort 48 patients well public databases, explored function using glioblastoma (GBM) models vitro vivo ....
Macrophages are sentinels in the organism which can resist and destroy various bacteria through direct phagocytosis. Here, we reported that expression level of mitochondrial ribosomal protein S35 (Mrps35) continued to decrease over infection time after Listeria monocytogenes (L. monocytogenes) infected macrophages. Our results indicated knockdown Mrps35 increased load L. This result supported played crucial roles infection. Moreover, performed comprehensive proteomics analyze differentially...
Infection of CD4- cells by HIV-1 is well documented, but the mechanism responsible remains a matter discussion. Previously we modified an virus strain, NL4-3, deleting Env proteins (gp41 and gp120) inserting enhanced green fluorescent protein (EGFP), found that Env(-) infects several types cells. Here, have prepared from both CD4” cell line, 293T, CD4+ lines, CEM SUPT1, either type infectious for lines. Replication virus-infected was demonstrated p24 gag assays real-time reverse...
T cells mediate adaptive immunity in diverse anatomic compartments through recognition of specific antigens via unique cell receptor (TCR) structures. However, little is known about the spatial distribution an organism's TCR repertoire. Here, using high-throughput sequencing (TCRseq), we investigated repertoires sixteen tissues healthy C57B/L6 mice. We found that generally classified into three categories (lymph nodes, non-lymph node and small intestine) based on sequence similarity. Clonal...
Objective To investigate significance of T lymphocyte subsets in peripheral blood the recovery period children with asthma. Methods measure CD3 + cell, CD4 CD8 cell and +/CD8 ratio by indirect immunofluorescence compare results. Results The levels cell,CD4 /CD8 asthma were significantly lower than those normal subjects(P ＜ 0. 01,0. 05 ); was also higher that subjects (P ).There no significant differences level between healthy subjects(P.＞ 05). Conclusion There are imbalances sebsets ,The may...