A5100453032- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- Fuel Cells and Related Materials
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Bone Metabolism and Diseases
- Spinal Fractures and Fixation Techniques
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Spinal Cord Injury Research
- Intracranial Aneurysms: Treatment and Complications
- Immune cells in cancer
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
Gansu University of Traditional Chinese Medicine
2021-2024
Wenzhou Medical University
2021-2024
Dongyang People's Hospital
2021-2024
Gansu Provincial Hospital
2024
Taian City Central Hospital
2024
Southern Medical University
2017-2023
Xijing Hospital
2020-2022
Air Force Medical University
2020-2022
Central South University of Forestry and Technology
2022
Central South University
2022
MicroRNA-381 (miR-381) has been reported to play suppressive or promoting roles in different malignancies. However, the expression level, biological function, and underlying mechanisms of miR-381 gastric cancer remain poorly understood. Our previous study indicated that transmembrane protein 16A (TMEM16A) contributed migration invasion predicted poor prognosis. In this study, we found inhibited metastasis through targeting TMEM16A expression. MiR-381 was analyzed using bioinformatic software...
Abstract Twist-1 and miRNAs have been reported to be associated with tumor metastasis angiogenesis. However, the relationship between function of remain largely undefined. We aimed reveal Twist-1-related miRNA expression profile determine whether functions in vasculogenic mimicry (VM) by regulating hepatocellular carcinoma (HCC). Results showed that miR-27a-3p was consistently down-regulated HCC cell lines tissue samples displaying high Twist-1. Both loss- gain-of-function assays revealed...
Gliomas are the most common malignant primary brain tumors in adults and exhibit a spectrum of aberrantly aggressive phenotype. Although increasing evidence indicated that deregulation microRNAs (miRNAs) contributes to tumorigenesis invasion, little is known about roles miR-204-5p human gliomas. In present study, expression clinical glioma tissues was measured by qRT-PCR. The effects on cell growth metastasis were examined overexpressing or inhibiting miR-204-5p. We found level significantly...
MicroRNAs (miRNAs) play vital roles in cell proliferation, differentiation and apoptosis hepatocellular carcinoma (HCC). miR-26b has been confirmed as an important regulator carcinogenesis other pathological processes. miR-26b-5p is one member of the mature miR-26 family, its functional role angiogenesis HCC remains unknown. Here, we demonstrate that expression was significantly decreased tissues lines compared with normal liver cells by quantitative real-time polymerase chain reaction...
Our previous study found that dysregulated microRNA-146a-5p (miR-146a-5p) is involved in oesophageal squamous cell cancer (ESCC) proliferation. This article aimed to evaluate its detailed mechanisms ESCC epithelial-mesenchymal transition (EMT) progression.Invasion assay, qRT-PCR and western blotting were used validate the roles of miR-146a-5p Notch2 EMT progression. miRNA target gene prediction databases dual-luciferase reporter assay gene.miR-146a-5p inhibitor led increase invaded cells,...
Accumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. We aimed to evaluate its expression level the potential for diagnosis prognosis oesophageal squamous cell (ESCC). examined miR-146a 62 pairs of ESCC cancerous matched paracancerous tissue, 115 formalin-fixed paraffin-embedded (FFPE) tissue samples serum from 154 patients healthy volunteers using quantitative reverse transcription–PCR (qRT–PCR). Kaplan–Meier method,...
Abstract MicroRNAs (miRNAs) play a critical role in regulation of numerous biological processes and pathogenesis variety diseases. In addition, miRNAs contribute to carcinogenesis by acting as oncogenic or tumor suppressive. Circulating including miR-150-5p are associated with colorectal cancer progression, the putative targets include suppressor gene, TP53. Here we sought investigate miR-150-5p-TP53 signaling pathway proliferation colon determine expression levels miR-miR-150-5p TP53...
In this study, we explored the actions of miR-199a/b-5p during hepatocellular carcinoma (HCC) progression and its potential target genes. Through heatmap miRNA expression analysis 15 matched HCC tumor adjacent non-tumor liver tissues from TCGA database, detected 19 mRNAs that were upregulated 13 downregulated specifically in HCC. Among these, miR-199 family members tumors cell lines, as compared to controls. Low was also associated with poor overall survival patients. overexpression lines...
The microRNA (miRNA) profile changes in the tumor-associated macrophages. However, role of miR-106b-5p glioblastoma-associated macrophages is poorly understood.In our study, and M2 macrophage markers were detected by qRT-PCR Western blotting THP1 cells, with conditioned medium from U251 cells or response to IL-4 stimulation M1 stimulated LPS IFN-γ. IFN regulatory factor (IRF1) was identified as a target glioma infiltrating luciferase reporter assay. molecular mechanisms involved...
Currently, the use of stem cell transplantation for treatment osteoporosis is a popular research topic. In general, promotion osteogenic differentiation cells goal researchers. MicroRNAs (miRNAs miRs) are critical regulatory factors induction, and miR‑9 miR‑10 have been substantiated to be involved in process, yet underlying mechanisms remain unclear. The present study investigated role bone marrow-derived mesenchymal (BMSCs) aimed elucidate mechanism differentiation. Using MTT assay RT-PCR,...
The mortality and morbidity of hepatocellular carcinoma (HCC) are still unacceptably high, despite decades extensive studies. Aerobic glycolysis is a hallmark cancer metabolism, closely relating to invasion metastasis HCC. MicroRNAs (miRNAs) involved in the regulation aerobic glycolysis. miR-183-5p, an oncogenic miRNA, highly expressed HCC, but regulatory mechanism miR-183-5p migration, HCC remains unclear.To elucidate whether affects regulate migration explore its mechanism.We attempted...
Hepatocellular carcinoma (HCC) is one of the most common human malignant diseases in world, and mechanisms underlying HCC carcinogenesis progression need further investigation. MicroRNAs play important roles development cancer, miR-500a suggested to be deregulated some types cancer. However, molecular remain unknown.The expression was analyzed The Cancer Genome Atlas (TCGA) database examined 33 pairs tissues matched nontumor tissues. correlation between prognosis patients from survival data...
Stomach adenocarcinoma (STAD) is the second leading cause of cancer death and a fuller understanding its molecular basis needed to develop new therapeutic targets. miRNA mRNA data were downloaded from The Cancer Genome Atlas database, differentially expressed miRNAs genes identified. target screened by prediction tools. Furthermore, biological function these was investigated. Several key their selected for validation using quantitative real-time polymerase chain reaction (qRT-PCR). Gene...
Abstract It is well known that the sine oculis homeobox 4 (SIX4) expression very relevant to progression of multiple cancers. Moreover, we found miR‐802 could directly target SIX4. However, precise mechanism in glioblastoma multiforme (GBM) still unknown. The aim this study investigate roles miR‐802/SIX4 axis GBM. Here, our results showed SIX4 was obviously increased GBM tissues and cell lines, level distinctly decreased. What more, negatively related tissues. Furthermore, evidently...
MicroRNAs (miRNAs) regulate multiple biological processes and participate in various cardiovascular diseases. This study aims to investigate the role of miR-339-5p cardiomyocyte hypertrophy involved mechanism. Neonatal rat cardiomyocytes (NRCMs) were cultured stimulated with isoproterenol (ISO). The hypertrophic responses monitored by measuring cell surface area expression markers including β-myosin heavy chain (β-MHC) atrial natriuretic factor (ANF). Bioinformatic prediction tools...
This study aims to examine whether miR-31 promotes endogenous NSC proliferation and be used for spinal cord injury management. In the present study, morpholino knockdown of induced abnormal neuronal apoptosis in zebrafish, resulting impaired development tail. agomir transfection NSCs increased Nestin expression decreased ChAT GFAP levels. mouse by upregulating Notch signaling pathway, more entered G1; was inhibited inactivation. Injection a into models could effectively restore motor...