A5100639227- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Dark Matter and Cosmic Phenomena
- Atomic and Subatomic Physics Research
- Neutrino Physics Research
- Medical Imaging Techniques and Applications
- Black Holes and Theoretical Physics
- Lung Cancer Treatments and Mutations
- Advanced NMR Techniques and Applications
- Recommender Systems and Techniques
- Management of metastatic bone disease
- Frailty in Older Adults
- Mobile Crowdsensing and Crowdsourcing
- Oceanographic and Atmospheric Processes
- Brain Metastases and Treatment
- Gastrointestinal motility and disorders
- Viral-associated cancers and disorders
- Open Source Software Innovations
- Nuclear physics research studies
- Lung Cancer Research Studies
- Lexicography and Language Studies
- Nutrition and Health in Aging
Shandong University
2024-2025
Shanghai Jiao Tong University
2025
Academy of Military Medical Sciences
2022-2025
Institute of Particle Physics
2025
Institute of Nuclear and Particle Physics
2025
Institute of Business Administration Karachi
2024
Carnegie Mellon University
2024
Chung-Ang University
2024
University of Chinese Academy of Sciences
2020-2024
Peking University
2009-2024
Effective interventions to improve prognosis in metastatic esophagogastric cancer (EGC) are urgently needed. We assessed the effect of early integration interdisciplinary supportive care for patients with EGC on overall survival (OS).
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data showed the promising antitumor activity of afatinib EGFR-overexpressing ESCC. This proof-of-concept, phase II trial assessed efficacy and safety pretreated metastatic ESCC patients (n = 41) with EGFR overexpression (NCT03940976). The study met its primary endpoint, a confirmed objective...
Background: Chronic stress is associated with detrimental effects on physical health, such as chronic restraint (CRS), which can damage the intestinal tract. Although tryptophan has many benefits in maintaining underlying mechanism of its protective against stress-induced injury remains unclear. Methods: In this study, we constructed a CRS model by using behavioral device mice were restrained for 6 h per day over 14 days and investigated effects, well potential high-tryptophan diet (0.4%...
Abstract Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit from the first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy. However, effects of HRD on clinical outcomes chemotherapy and PARPi therapy have not rigorously evaluated in Chinese EOC patients. Here, we developed an assay applied it to two large retrospectively collected patient cohorts. In adjuvant cohort (FACT, N...
ABSTRACT Human genome is continuously threatened by endogenous and exogeneous sources of DNA damage, damage repair (DDR) mechanisms are vital for instability cancer prevention. Homologous recombination (HRR) one the most important DDR because its high-fidelity. BRCA1/2 have long been best characterized HRR genes, but other non-BRCA1/2 genes should not be overlooked. In this study, we illustrate that RAD51D an gene in Chinese ovarian patients, from perspectives including prevalence (2.9%...
We propose two new ocean wind retrieval models for right circular-vertical (RV) and circular-horizontal (RH) polarizations respectively from the compact-polarimetry (CP) mode of RADARSAT Constellation Mission (RCM), which is scheduled to be launched in 2019. For compact RV-polarization (right circular transmit vertical receive), we build model (denoted CoVe-Pol model) by employing geophysical function (GMF) framework a sensitivity analysis. RH polarization horizontal CoHo-Pol using quadratic...
Docosahexaenoic acid-acylated phloridzin (PZ-DHA), a novel polyphenol fatty acid ester derivative, is synthesized through an acylation reaction of (PZ) and docosahexaenoic (DHA). PZ-DHA more stable than DHA exhibits higher cellular uptake bioavailability PZ.The study aims to investigate the effects on insulin resistance in skeletal muscle related mechanisms; we used palmitic (PA)-treated C2C12 myotubes as model.We found that increased activity AMP-activated protein kinase (AMPK) improved...
Abstract Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit from the first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy. However, effects of HRD on clinical outcomes chemotherapy and PARPi therapy have not rigorously evaluated in Chinese EOC patients. Here, we developed an assay applied it to two large patient cohorts. In adjuvant cohort (FACT, N = 380), status...
e17573 Background: Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit from the first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy. However, effects of HRD on clinical outcomes chemotherapy and PARPi therapy have not rigorously evaluated in Chinese EOC patients. Methods: We developed a customized sequencing panel named “Precision Human Assay”.This assay contains two sets...
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Background: Effective interventions to improve prognosis in metastatic oesophagogastric cancer (EGC) is urgently needed. Since EGC had the highest presence of malnutrition and psychological stress, which are closely related OS patients, we assessed effect early integration interdisciplinary palliative care patients with on overall survival.Methods: A single-centre, open-label, phase 3, randomised, controlled trial was conducted Peking University Cancer Hospital & Institute. Patients...