A5101831994- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- PARP inhibition in cancer therapy
- IL-33, ST2, and ILC Pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Ovarian cancer diagnosis and treatment
- Enhanced Recovery After Surgery
- Inflammation biomarkers and pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Colorectal Cancer Treatments and Studies
- Blood transfusion and management
- Advanced Glycation End Products research
- Advanced Radiotherapy Techniques
- Cardiac Arrest and Resuscitation
- Breast Cancer Treatment Studies
- Eosinophilic Esophagitis
- Heat shock proteins research
- Lipoproteins and Cardiovascular Health
- Galectins and Cancer Biology
- Flavonoids in Medical Research
- Effects of Radiation Exposure
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Methemoglobinemia and Tumor Lysis Syndrome
Lanzhou University
2024
Guangdong Academy of Sciences
2023
Liaocheng People's Hospital
2017-2021
Fujian Medical University
2020-2021
Sir Run Run Shaw Hospital
2007-2021
Zhejiang University
2008-2021
Second Affiliated Hospital of Fujian Medical University
2020-2021
Genecast (China)
2021
China-Japan Friendship Hospital
2018
Jinhua Academy of Agricultural Sciences
2012
Generally considered as a potent pro‑inflammatory signal, β‑galactosidelectin suppresses T cell receptor activation, can both promote and inhibit integrin‑mediated adhesion is required in nuclear pre‑mRNA splicing. Galectin‑9 (Gal‑9), member of β‑galactoside lectin, involved many processes cell‑mediated diseases (such autoimmune asthma) immunomodulation macrophages. Macrophages are the occurrence inflammation, development digestion other stages. At different stages inflammatory response,...
Snail, a potent repressor of E-cadherin expression, plays key role in epithelial-to-mesenchymal transition (EMT) epithelial cancer. Recently, EMT and stemness programs are found linked together. In the current study, expression Snail its contribution to cancer stem cell (CSC) marker invasiveness, self-renewal, clonogenicity, tumorigenicity pancreatic cells were studied. Our results showed that was highly expressed CSChigh line Panc-1. Stable, short hairpin RNA (shRNA)-mediated knockdown...
This study aimed to observe the effects of lung-protective ventilation (LPV) on oxygenation index (OI) and postoperative pulmonary complications (PPCs) after laparoscopic radical gastrectomy in middle-aged elderly patients. A total 120 patients who were scheduled undergo with an expected time >3 h randomly divided into conventional (CV group) tidal volume (TV) 10 mL/kg without positive end-expiratory pressure (PEEP), (PV 7 TV personal level PEEP regular recruitment maneuver every 30 min....
Abstract Homologous recombination deficiency (HRD) testing has been approved by FDA for selecting epithelial ovarian cancer (EOC) patients who may benefit from the first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy. However, effects of HRD on clinical outcomes chemotherapy and PARPi therapy have not rigorously evaluated in Chinese EOC patients. Here, we developed an assay applied it to two large retrospectively collected patient cohorts. In adjuvant cohort (FACT, N...
Sepsis is a systemic inflammatory response during infection. There are limited therapeutic options for sepsis patients. Interleukin (IL)-33 has been reported recently with beneficial effect in mouse sepsis.In this study, we initiated clinical study to measure serum levels of pro-inflammatory cytokines including IL-33 Next, employed cecal ligation and puncture (CLP) the role sepsis. To further dissect molecular mechanism, used vivo knockout models vitro knockdown murine embryonic fibroblasts...
To investigate the effects of ghrelin on delayed gastrointestinal transit in alloxan-induced diabetic mice.A mouse model was established by intraperitoneal injection with alloxan. Mice were randomized into two main groups: normal mice group and treated at doses 0, 20, 50, 100 200 mug/kg ip. Gastric emptying (GE), intestinal (IT), colonic (CT) studied after they had a phenol red meal following ghrelin. Based most effective dosage, atropine given 1 mg/kg 15 min before for each measurement. The...
To explore the myoblast formation around urethra and increase in urethral resistance of bone marrow mesenchymal stem cells or muscle-like cells/calcium alginate composite gel injection therapy effect on LPP SUI rat model.Isolation, cultivation, identification SD cell were performed. 5-Azacytidine was introduced to induce cells. produced 72 6-week-old female Sprague-Dawley rats, which divided into four groups: cell-gel group, Gel mock control group. One, 4, 8 weeks after injection, leak point...
We performed the present in vivo study to investigate effect of hydroxyethyl starch (HES) on intestinal production inflammatory mediators and activation transcription factors during endotoxemia. Rats with endotoxemia induced by lipopolysaccharide (LPS) (5 mg/kg, IV) were treated HES (16 mL/kg, or saline (64 IV). At 2, 3, 6 h after LPS challenge, rat ileal tissues collected. Various mediator levels (tumor necrosis factor-alpha, interleukin [IL]-6, cytokine-induced neutrophil...
Purpose: To assess the anti-metastasis effects of thymol on human colorectal cancer cells. Methods: Human adenocarcinoma cell HT29 was incubated with varying concentrations thymol. Cell viability, migration and invasion were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5dipheny-tetrazoliumbromide (MTT) Transwell assays, respectively. Matrix metalloproteinase-2 9 (MMP-2 MMP-9) analyzed gel zymogram assay. Epithelial-mesenchymal transition (EMT)-associated gene expression signaling pathway...
Abstract Background This trial aimed to evaluate the effects of a protective ventilation strategy on oxygenation/pulmonary indexes in patients undergoing robot-assisted radical prostatectomy (RARP) steep Trendelenburg position. Methods In phase 1, most optimal positive end-expiratory pressure (PEEP) was determined 25 at 11 cmH 2 O. 2, 64 were randomized traditional group with tidal volume (VT) 9 ml/kg predicted body weight (PBW) and VT 7 PBW PEEP recruitment maneuvers (RMs). The primary...
Background and aim: The reduced oxygen content perfusion pressure during acute normovolemic hemodilution (ANH) controlled hypotension (CH) raise concerns about hypoperfusion ischemic injury to the brain. In this study on rats, we examined brain damage following four different degrees of ANH combined with CH. Methods: Forty rats were randomly assigned receive a sham operation or CH [with hematocrit (Hct) 30, 25, 20 15%]. was performed after baseline physiological parameters had been monitored...
The Helankou petroglyphs offer precious data for understanding the lifeways of ancient pastoralists. However, in Helankou, combination unique climate conditions and complex hydrochemical environments has accelerated weathering sandstone-petroglyph carriers, leading to numerous at risk vanishing. In response, this study employed freeze-thaw wet-dry cycle experiments simulate actual environmental sandstone. Subsequently, sandstone that underwent was subjected further testing analysis. goal...
Background: Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes. Some studies have indicated that HES may anti‐inflammatory effects. The present in vivo study was performed to investigate effects on hepatic production cytokines and activation transcription factors sepsis. Methods: Adult male Sprague‐Dawley rats were randomly divided into four groups: challenged with lipopolysaccharide (LPS) (5 mg kg −1 ) treated saline (64 ml ); LPS (16 injected control. Each...
A 22‐year‐old woman with an initial diagnosis of ‘ruptured ectopic pregnancy’ and ‘hemorrhagic shock’ was sent to the operation room for surgical treatment. The mucocutaneous color deeply cyanosed pulse oximeter oxygen saturation (SpO 2 ) only 86% after tracheal intubation (100% O ). ‘Chocolate‐brown’ blood observed methemoglobinemia considered. Then arterial gas (ABG) sample obtained, intravenous infusion methylene blue vitamin C followed. patient recovered quickly, later two other patients...
The present study aimed to isolate a potential antagonist Bacillus sp. and evaluate its capacity for controlling pathogenic Vibrio parahaemolyticus in aquaculture.Strain JK08, which showed inhibitory activity against V. VP02r, was isolated from Penaeus vannamei pond. Based on morphological, physiological, biochemical characteristics phylogenetic analysis, strain JK08 identified as Through culture condition optimization, the maximal inhibition zone diameter (18.19 ± 0.16 mm) observed when...