A5032875933- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Stress Responses and Cortisol
- Bone health and osteoporosis research
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Bone Metabolism and Diseases
- Neuroendocrine regulation and behavior
- Estrogen and related hormone effects
- Advanced Neuroimaging Techniques and Applications
- Corporate Governance and Law
- Breast Lesions and Carcinomas
- Dental Radiography and Imaging
- Ginseng Biological Effects and Applications
- Spinal Fractures and Fixation Techniques
- Phytoestrogen effects and research
- Renal Diseases and Glomerulopathies
- Cervical and Thoracic Myelopathy
- NF-κB Signaling Pathways
- Vascular Tumors and Angiosarcomas
- Natural product bioactivities and synthesis
- Endodontics and Root Canal Treatments
- Tuberous Sclerosis Complex Research
- Reproductive Biology and Fertility
- Surgical Sutures and Adhesives
China Medical University
2025
Zhejiang University
2011-2022
Zhejiang Hospital
2012-2022
Sir Run Run Shaw Hospital
2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019-2020
Wenzhou Medical University
2019-2020
Abbott Fund
2011
Abbott (United States)
2010
Second Affiliated Hospital of Zhejiang University
2007
Shanghai Medical College of Fudan University
1994
Methods.This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5-15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback.Forty-nine females <9 years old with Tanner breast stage ≥2 before 8 6 males <10 genital 9 stimulated LH ≥10 IU/L bone age advance ≥1 year were enrolled.Results.Subjects treated 3.9 ± 2.0 years.Mean peak GnRH-stimulated FSH prepubertal after the first dose remained suppressed throughout...
Methods. This prospective US multicenter trial of leuprolide acetate 1-month depot (7.5–15 mg) for central precocious puberty utilized an open-label treatment period, long-term follow-up, and adult callback. Forty-nine females <9 years old with Tanner breast stage ≥2 before 8 6 males <10 genital 9 stimulated LH ≥10 IU/L bone age advance ≥1 year were enrolled. Results. Subjects treated years. Mean peak GnRH-stimulated FSH prepubertal after the first dose remained suppressed throughout...
Gonadotropin-releasing hormone analogs (GnRHa) are the treatment of choice for CPP. We investigated growth in GnRHa-naïve subjects, treated with leuprolide acetate 1-month depot This prospective, open-label study had a long-term, observational, follow-up period. Forty-nine females and 6 males were enrolled. Leuprolide was administered intramuscularly every 28 days. Height rate during after until adulthood measured. Among 30 49 having an adult height (AH) measurement, 29 target heights...
Pubertal hormones play an important role in brain and psychosocial development. However, the of abnormal HPG axis states altering function structure remains unclear. The present study is aimed at determining whether there were significant differences gray matter volume (GMV) resting state (RS) functional connectivity (FC) patterns girls with idiopathic central precocious puberty (CPP) peripheral (PPP). We further explored correlation between these serum pubertal hormone levels. To assess...
PURPOSE This study aimed to verify whether the use of Kaiser score can improve diagnostic performance in breast magnetic resonance imaging (MRI) for suspicious lesions and avoid further invasive approaches. METHODS retrospective enrolled 97 patients who underwent MRI before undergoing biopsy or surgery. Evaluations were conducted on all images individually by 2 radiologists using score. Neither radiologist had knowledge final histopathological diagnosis. The ability diagnosis was established...
Immunoglobulin E (IgE) antibodies may play a role in the development of kidney diseases that are related to hypersensitivity reactions. Patients with idiopathic nephrotic syndrome often exhibit increased serum IgE levels and this be sensitivity steroid treatment. In present study, 120 patients different types primary (PNS) were analysed found significantly elevated cases minimal change (MCNS) compared membranous nephropathy or membranoproliferative glomerulonephritis. No difference level was...
Central precocious puberty (CPP) has been shown to exert significant effects on psychosocial development. These early puberty-related hormones and functional changes are considered be associated with specific brain However, the biological mechanisms underlying sculpting of human architecture modulation transformation by hormonal maturation remain elusive, especially during phase CPP. The current investigation aims specify regions in which hormone-related occur CPP their relationships...
Objectives: To evaluate the effects of proteasome inhibitor MG-132 on expression nuclear factor (NF)-κB p65, (I)-κB, tumour necrosis (TNF)-α, and interleukin (IL)-1β in cartilage synovial tissues rats with osteoarthritis (OA), to investigate role that ubiquitin/proteasome system (UPS) plays OA process.
Purpose: The pubertal growth suppressive effects of gonadotropin hormone releasing agonists (GnRHa) are well-known, although it remains unclear if long-term GnRHa treatment influences the brain function treated children. present study investigated differences in homotopic resting-state functional connectivity patterns girls with idiopathic central precocious puberty (ICPP) and without using voxel-mirrored (VMHC). Methods: Eighteen ICPP who underwent 12 months treatment, 40 treatment-naïve...
The onset of puberty and related hormones exerts significant effects on brain morphometric psychosocial development. biological mechanisms underlying how the reactivation hypothalamic-pituitary-gonadal (HPG) axis puberty-related hormonal maturation sculpts human architecture remain elusive. To address this question, 105 premature pubertal girls (age 8-11 years) without menstruation underwent structural scanning a 3T MR system, luteinizing hormone releasing (LHRH) stimulation test was used to...
Objective: To investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM DWI) in evaluating microstructure changes elderly white matter hyperintensities (WMH) patients and to analyze correlation between IVIM parameters severity grading cognitive scores. Methods: Sixty-two WMH Zhejiang Hospital were collected from December 2014 March 2018 underwent conventional magnetic resonance (MR) plain scan with different b values. The age was 60-92(74±10) years 37 males, 25...