A5102754574- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- Nutrition, Genetics, and Disease
- Animal Genetics and Reproduction
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- RNA and protein synthesis mechanisms
- Coenzyme Q10 studies and effects
- MicroRNA in disease regulation
- Bladder and Urothelial Cancer Treatments
- Immune Response and Inflammation
- Nutrition and Health in Aging
- Viral Infections and Immunology Research
- Diet and metabolism studies
Weill Cornell Medicine
2021-2024
Cornell University
2021-2024
Houston Methodist
2023
Methodist Hospital
2023
St. John's University
2017-2023
Soochow University
2017-2021
Baoding No.1 Central Hospital
2019
Shanghai University of Traditional Chinese Medicine
2013
Vanderbilt University Medical Center
2013
Traditional Chinese Medicine Hospital of Kunshan
2013
Isoacteoside (is a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., which is an anti-inflammatory herb widely used in traditional Chinese medicine. However, the exact mechanism of activity isoacteoside not completely understood. In this study, its was elucidated mouse macrophages.The expression NF-κB pathway, MAPK iNOS, TNF-α, IL-6 and IL-1β evaluated using Western blotting, quantitative real-time PCR or ELISA. TLR4 dimerization determined by transfecting HEK293T cells...
The proto-oncogene Bcl3 induces survival and proliferation in cancer cells; however, its function regulation ovarian (OC) remain unknown. Here, we show that expression is increased human OC tissues. Surprisingly, found addition to promoting survival, proliferation, migration of cells, promotes both constitutive interferon-γ (IFN)-induced the immune checkpoint molecule PD-L1. cells further by IFN, resulting PD-L1 transcription. mechanism consists an IFN-induced, Bcl3- p300-dependent promoter...
Overexpression of the pro-angiogenic chemokine IL-8 (CXCL8) is associated with a poor prognosis in several solid tumors, including epithelial ovarian cancer (EOC). Even though histone deacetylase (HDAC) inhibition has shown remarkable antitumor activity hematological malignancies, it been less effective EOC. Here we report results that may explain decreased efficiency HDAC EOC, based on our data demonstrating specifically induces expression IL-8/CXCL8 SKOV3, CAOV3, and OVCAR3 cells....
Epithelial-to-mesenchymal transition (EMT) contributes significantly to chemotherapy resistance and remains a critical challenge in treating advanced breast cancer. The complexity of EMT, involving redundant pro-EMT signaling pathways its paradox reversal process, mesenchymal-to-epithelial (MET), has hindered the development effective treatments. In this study, we utilized Tri-PyMT EMT lineage-tracing model mice single-cell RNA sequencing (scRNA-seq) comprehensively analyze status tumor...
Salivary adenoid cystic carcinoma (SACC) is one of the most frequent carcinomas derived from salivary gland. Growing evidence implied involvement microRNAs (miRNAs) in SACC progression and metastasis. This study aimed to determine regulatory role miR-140-5p metastasis explore underlying mechanisms.MiR-140-5p survivin mRNA expression levels were determined by quantitative real-time PCR; protein evaluated western blot assay; cell proliferation, growth, invasion, apoptosis caspase-3 activity...
Nasopharyngeal carcinoma (NPC) is one common head and neck malignancy with leading cause of cancer-related death. Long noncoding RNAs (lncRNAs) have been reported to play essential roles in progression, prognosis treatment NPC. However, the exact role lncRNA zinc finger antisense 1 (ZFAS1) NPC progression its potential mechanism remain largely unknown.The expressions ZFAS1 microRNA-135a (miR-135a) were measured tissues or cells by quantitative real-time polymerase chain reaction (qRT-PCR)....
Although inhibitors of epigenetic regulators have been effective in the treatment cutaneous T cell lymphoma (CTCL) and other hematopoietic malignancies, they less solid tumors, including ovarian cancer (OC). We previously shown that inhibition histone deacetylase (HDAC) activity induces expression pro-inflammatory pro-angiogenic chemokine interleukin-8 (CXCL8, IL-8) OC cells, resulting their increased survival proliferation. Here, we show addition to SKOV3, OVCAR3, CAOV3 HDAC CXCL8 HeLa but...
We have recently shown that IFNγ, produced during cancer therapy, induces expression of the Bcl3 proto-oncogene in ovarian (OC) cells, resulting their increased proliferation, migration, and invasion, but mechanisms are unknown. Here, we demonstrate IFNγ-induced is dependent on JAK1 STAT1 signaling, p65 NFκB. Furthermore, associated with an occupancy Ser-727 phosphorylated acetylated histone H3 at promoter. Our data indicate promotes pro-inflammatory chemokine interleukin-8 (IL-8) OC cells....
Epithelial-to-mesenchymal transition (EMT) contributes significantly to chemotherapy resistance and remains a critical challenge in treating advanced breast cancer. The complexity of EMT, involving redundant pro-EMT signaling pathways its paradox reversal process, mesenchymal-to-epithelial (MET), has hindered the development effective treatments. In this study, we utilized Tri-PyMT EMT lineage-tracing model single-cell RNA sequencing (scRNA-seq) comprehensively analyze status tumor cells....
Triple negative breast cancer (TNBC) cells express increased levels of the pro-inflammatory and pro-angiogenic chemokine interleukin-8 (IL-8, CXCL8), which promotes their proliferation migration. Because TNBC patients are unresponsive to current targeted therapies, new therapeutic strategies urgently needed. While proteasome inhibition by bortezomib (BZ) or carfilzomib (CZ) has been effective in treating hematological malignancies, it less solid tumors, including TNBC, but mechanisms...
Epithelial-to-mesenchymal transition (EMT) contributes significantly to chemotherapy resistance and remains a critical challenge in treating advanced breast cancer. The complexity of EMT, involving redundant pro-EMT signaling pathways its paradox reversal process, mesenchymal-to-epithelial (MET), has hindered the development effective treatments. In this study, we utilized Tri-PyMT EMT lineage-tracing model mice single-cell RNA sequencing (scRNA-seq) comprehensively analyze status tumor...
Objectives: To evaluate the effects of proteasome inhibitor MG-132 on expression nuclear factor (NF)-κB p65, (I)-κB, tumour necrosis (TNF)-α, and interleukin (IL)-1β in cartilage synovial tissues rats with osteoarthritis (OA), to investigate role that ubiquitin/proteasome system (UPS) plays OA process.
Abstract Epithelial-to-mesenchymal transition (EMT) contributes significantly to chemotherapy resistance and remains a critical challenge in treating advanced breast cancer. The complexity of EMT, involving redundant pro-EMT signaling pathways its paradox reversal process, mesenchymal-to-epithelial (MET), has hindered the development effective treatments. In this study, we utilized Tri-PyMT EMT lineage-tracing model single-cell RNA sequencing (scRNA-seq) comprehensively analyze status tumor...