A5080095911- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Immune cells in cancer
- Mesenchymal stem cell research
- Pain Management and Opioid Use
- Airway Management and Intubation Techniques
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Eosinophilic Esophagitis
- Enhanced Recovery After Surgery
- Anesthesia and Neurotoxicity Research
- IL-33, ST2, and ILC Pathways
- S100 Proteins and Annexins
- Heme Oxygenase-1 and Carbon Monoxide
- Cell Adhesion Molecules Research
- Cardiac Ischemia and Reperfusion
- Phagocytosis and Immune Regulation
- Anesthesia and Sedative Agents
- NF-κB Signaling Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Beetle Biology and Toxicology Studies
- Legionella and Acanthamoeba research
Sir Run Run Shaw Hospital
2013-2025
Zhejiang University
2015-2025
Zhongda Hospital Southeast University
2022
Xuzhou Medical College
2015-2020
Weatherford College
2020
Second Affiliated Hospital of Zhejiang University
2020
Army Medical University
2014
Daping Hospital
2014
This study aimed to observe the effects of lung-protective ventilation (LPV) on oxygenation index (OI) and postoperative pulmonary complications (PPCs) after laparoscopic radical gastrectomy in middle-aged elderly patients. A total 120 patients who were scheduled undergo with an expected time >3 h randomly divided into conventional (CV group) tidal volume (TV) 10 mL/kg without positive end-expiratory pressure (PEEP), (PV 7 TV personal level PEEP regular recruitment maneuver every 30 min....
<title>Abstract</title> Background Sepsis, a critical organ failure caused by an abnormal host response to infection, continues be significant worldwide medical issue. Despite advances in early recognition and treatment, sepsis mortality remains high, particularly severely ill individuals. Serum chloride, key electrolyte the balance of acids bases fluid homeostasis, has emerged as potential prognostic marker sepsis. However, previous studies have primarily relied on single time-point...
Sepsis is a systemic inflammatory response during infection. There are limited therapeutic options for sepsis patients. Interleukin (IL)-33 has been reported recently with beneficial effect in mouse sepsis.In this study, we initiated clinical study to measure serum levels of pro-inflammatory cytokines including IL-33 Next, employed cecal ligation and puncture (CLP) the role sepsis. To further dissect molecular mechanism, used vivo knockout models vitro knockdown murine embryonic fibroblasts...
The long‐term use of potent analgesics is often needed to treat chronic pain. However, it has been greatly hindered by their side effects such as addiction and withdrawal reactions. study seeks circumvent these drawbacks taking advantage a multifunctional delivery system based on nanoparticles target pathological neuroinflammation. A drug designed generated using mesoporous silica (MSNs) that are loaded with Δ9‐THC (Δ9‐tetrahydrocannabinol, cannabinoid) ARA290 (an erythropoietin‐derived...
// Junran Xie 1 , Dongju Xiao 2,3 Yun Xu Jinning Zhao Li Jiang Xuming Hu Yaping Zhang and Lina Yu 4 Department of Anesthesiology, Sir Run Shaw Hospital, School Medicine, Zhejiang University, Hangzhou, People's Republic China 2 Jiangsu Province Key Laboratory Xuzhou Medical College, Xuzhou, 3 Anesthesia Analgesia Application Technology, Second Affiliated Correspondence to: Yu, email: Keywords : mesenchymal stem cells, tetrahydrocannabinol, cannabinoid receptor, inflammation, pain, Immunology...
Pregabalin is commonly used as an analgesic for neuropathic pain. But pregabalin adjunct to a multimodal regimen - although standard clinical protocol in some settings has remained controversial. This meta-analysis was conducted identify the efficacy of management postoperative pain thoracotomy.Pubmed, Embase, Cochrane, Web Science, Springer, and Clinical Trial Register database were searched randomized controlled trials (RCTs) preventing thoracotomy. Review Manager 5.3 STATA 12.0 selected...
Vascular endothelial cell dysfunction involving syndecan (SDC) proteoglycans contributes to acute sepsis-associated lung injury (ALI), but the exact SDC isoform involved is unclear. We aimed clarify which SDCs are in ALI. A relevant gene expression dataset (GSE5883) was analysed for differentially expressed genes (DEGs) between lipopolysaccharide (LPS)-treated and control cells expression. Bioinformatic analyses predict DEG function were conducted using R language, Gene Ontology, Kyoto...
We aim to assess efficacy and safety of remifentanil or sulfentanyl combined with propofol during painless gastroscopic examination in patients. In this study, 270 patients were randomly divided into 3 groups: was given only group P; PR; PS the examination. Efficiency P significantly higher than that PR (P<0.01) [corrected]. lower (P<0.05). Incidence chest wall rigidity oxygen desaturation (P<0.05), whereas there no difference between groups (P>0.05). Propofol could provide satisfying...
Abstract Background This trial aimed to evaluate the effects of a protective ventilation strategy on oxygenation/pulmonary indexes in patients undergoing robot-assisted radical prostatectomy (RARP) steep Trendelenburg position. Methods In phase 1, most optimal positive end-expiratory pressure (PEEP) was determined 25 at 11 cmH 2 O. 2, 64 were randomized traditional group with tidal volume (VT) 9 ml/kg predicted body weight (PBW) and VT 7 PBW PEEP recruitment maneuvers (RMs). The primary...
JNK serves critical roles in numerous types of inflammation‑ and oxidative stress‑induced disease, including acute lung injury (ALI). JNK‑IN‑8 is the first irreversible inhibitor that has been described. However, whether can prevent lipopolysaccharide (LPS)‑induced ALI by inhibiting activation its downstream signaling poorly understood. The objective present study was to investigate specific therapeutic effects on LPS‑induced molecular mechanisms involved. attenuated myeloperoxidase...
Emotion dysregulation can cause abnormalities in human central nervous system, which turn affect the endocrine, immune, and enteric systems, thus reducing immune capacity increasing possibility of tumor induction. Several endogenous peptides newly discovered food-derived exogenous have been found could regulate emotions. This review discussed how from various sources emotions gut microbiota through mechanisms like microbiota-gut-brain axis, pathways, metabolic pathways. It also analyzed...
Mesenchymal stem cells have cannabinoid (CB) receptors type 1 and 2 can alleviate a variety of neuropathic pains, including chronic constriction injury (CCI). A selective CB2 receptor agonist is AM1241. In the present study, it was found that mice with CCI displayed longer duration mechanical thermal analgesia when intrathecally (i.t.) injected AM1241-treated mesenchymal cells, compared to those untreated or AM1241 alone. Moreover, CCI-induced upregulation phosphorylated extracellular...
Background: We explored the impact of mechanical ventilation (MV) on hospital mortality in septic patients based sepsis-3 criteria. Methods: performed a retrospective cohort study adult Intensive Care Unit (ICU) admissions from 2008 to 2012 tertiary teaching Boston, Massachusetts. Multivariate logistic regression explained relationship between MV and mortality. Results: In total, 5,783 ICU met for criteria with 2,783 (48.1%) receiving invasive ventilation. Compared sepsis without MV,...
Background: Chronic post-thoracotomy pain is still an obstacle for lung-cancer patients even after less invasive surgical procedures. It unclear whether intercostal analgesia as useful in the prevention of postoperative chronic it acute video-assisted thoracoscopic surgery (VATS). The purpose this study was to evaluate efficacy perioperative via a multimodal analgesic regimen VATS during 6 months follow-up. Methods: We identified 837 cases from August 2016 2018. Patients were treated by with...
The severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which causes the disease 2019 (COVID-19), is spreading worldwide. Although COVID-19 epidemic has passed its peak of transmission, harm it caused deserves our attention. Scientists are striving to develop medications that can effectively treat symptoms without causing any adverse reactions. SARS-CoV-2 inhibitory peptides derived from animal proteins have a wide range functional activities in addition safety. Identifying...