A5005868121- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Gallbladder and Bile Duct Disorders
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Inflammasome and immune disorders
Qilu Hospital of Shandong University
2016-2025
Guiyang Medical University
2023-2025
Fudan University
2012-2024
Shandong University
2014-2024
Northwest A&F University
2019-2024
Zhejiang Chinese Medical University
2024
Huzhou Central Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
First Affiliated Hospital of Zhengzhou University
2012-2023
Zhejiang A & F University
2016-2023
Chemoresistance is one of the main causes poor prognosis in pancreatic cancer patients. Understanding mechanisms implicated chemoresistance critical to improving patient outcomes. Recent evidences indicate that long noncoding RNAs (lncRNAs) are involving cancer. However, lncRNAs contribute resistance and remain largely unknown. The objective this study construct a chemoresistance-related lncRNA-associated competing endogenous RNA (ceRNA) network identify key regulating network.Firstly,...
Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all way through an environment-friendly approach. Conventionally, have assembled by dissimilar methods, but regrettably rely on negative impact natural environment. Amalgamation means plant extract is alternate conservative methods. Scutellaria barbata species was used majorly food or medicines against various diseases, and extensive research conducted their therapeutic properties....
Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote development of hepatocellular carcinoma (HCC). However, underlying mechanism remains largely unknown.The expression and promoter activity lncTCF7 were measured by quantitative real-time polymerase chain reaction (qRT-PCR) luciferase reporter assay. The function STAT3 binding site region was tested assay with nucleotide substitutions. to confirmed chromatin...
Occult liver metastases in patients with pancreatic ductal adenocarcinoma (PDAC) affects treatment strategies and prognosis. Diffusion-weighted imaging (DWI), including non-Gaussian DWI may help to evaluate tumor biological behavior. To the diagnostic value of parameters predicting occult PDAC. Prospective. 115 participants pathologically confirmed PDAC (male = 71, mean age 59.8 ± 9.9 years). metastasis was defined as those detected by CT or MRI within 6 months pancreatectomy. DWI,...
Chemoresistance is one of the causes poor prognosis in pancreatic cancer patients. However, mechanisms resistance remain unclear. Here we screened miRNAs associated with drug cancer, and identified a panel dysregulated gemcitabine-resistance cells, including 13 downregulated 20 upregulated miRNAs. Further studies focusing on miR-497 demonstrated that suppressed cells proliferation, decreased percentage S phase re-sensitized to gemcitabine erlotinib, attenuated migration invasion capacities....
Objectives: To identify plasma microRNA (miRNA) markers of pancreatic cancer (PC). Background: Accurate pretreatment diagnosis PC remains challenging, whether miRNAs could be used as biomarkers in unknown. Methods: In this multiphase multicenter study, peripheral blood samples were obtained preoperatively 3 phases: the discovery phase [7 patients with PC, 6 chronic pancreatitis (CP), and 5 healthy volunteers (N)], preliminary validation (29 16 CP, 31 N), large sample (156 65 N, 57 27...
Objective The purpose of this study was to improve the differentiation between malignant and benign thyroid nodules using deep learning (DL) in category 4 5 based on Thyroid Imaging Reporting Data System (TI-RADS, TR) from American College Radiology (ACR). Design Methods From June 2, 2017 April 23, 2019, 2082 ultrasound images 1396 consecutive patients with confirmed pathology were retrospectively collected, which 1289 (TR4) 793 (TR5). Ninety percent B-mode applied for training validation,...
The functional relevance and effects of the pyroptosis executioner gasdermin D (GSDMD) on severe acute pancreatitis (SAP)-associated lung injury are unclear. We established caerulein-induced mouse models SAP-associated injury, which showed that GSDMD-mediated was activated in both pancreatic tissues. Compared with Gsdmd wild-type SAP models, knockout (Gsdmd-/- ) ameliorated SAP-induced pancreas related injury. Additionally, we investigated disulfiram treatment SAP. Disulfiram is a Food Drug...
Carboxyl terminus of heat shock protein 70-interacting (CHIP) is an E3 ubiquitin ligase that involved in quality control and mediates several tumor-related proteins many cancers, but the function CHIP pancreatic cancer not known. Here we show interacts ubiquitinates epidermal growth factor receptor (EGFR) for proteasome-mediated degradation cells, thereby inhibiting activation EGFR downstream pathway. suppressed cell proliferation, anchor-independent growth, invasion migration, as well...
Pancreatic cancer is characterized by extremely poor prognosis because of early recurrence and metastasis, increasing evidence supports the critical role microRNA in progression. Here we identified that microRNA-34b functioned as a tumor-suppressing targeting oncogenic Smad3 pancreatic cancer. As hypovascular tumor with potential endoplasmic reticulum stress microenvironment, miR-34b was silenced after ER inducer thapsigargin (Tg) treatment negatively regulated chaperone glucose protein 78...
Biomarkers for the early diagnosis of pancreatic cancer (PC) are urgent needed. Plasma microRNAs (miRNAs) might be used as biomarkers cancer. We analyzed 361 plasma samples from 6 surgical centers in China and performed machine learning approach. gain insight association between aberrant miRNA expression disease. 671 were screened discovery phase 33 training 13 validation phase. After phase, 2 diagnostic panels constructed comprising 3 panel I (miR-486-5p, miR-126-3p, miR-106b-3p) II...
It has been demonstrated that circulating MicroRNAs (miRNAs) could be potential biomarkers for cancer diagnosis and prognosis. For pancreatic (PCa), little is known about miR-221-3p biological function or its prognostic value. In the current study, we profiled expression in PCa cell lines. Compared with normal pancreases ductal epithelial cells, up-regulated all lines analysed. SW1990 overexpression of increased proliferation inhibited apoptosis, while inhibition decreased growth rate...
The effects of PIM-1 on the progression pancreatic cancer remain unclear, and prognostic value levels in tissues is controversial. Additionally, expression clinical plasma have not been reported.The biological behaviours were analysed. detected, was evaluated.We found that knockdown cells suppressed proliferation, induced cell cycle arrest, enhanced apoptosis, resensitized to gemcitabine erlotinib treatment, inhibited ABCG2 EZH2 mRNA expression. Our results indicated EGFR pathway formed a...
Development of novel methods is needed for the synthesis nanoparticles. Attention on such particles has elevated disquiet about eco-friendly manner their fabrication methods. In present study, we equipped and synthesized gold nanoparticles (AuNPs) from Panax notoginseng; investigated as an environmentally friendly non-toxic substrate. Amalgamation AuNPs was distinguished by numerous studies UV-absorbance it shows peak values in range 520–550 nm. Nanoparticles sizes are confirmed dynamic...