A5101743037- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Atrial Fibrillation Management and Outcomes
- Liver physiology and pathology
- Helicobacter pylori-related gastroenterology studies
- Mental Health Research Topics
- Gastrointestinal Tumor Research and Treatment
- Phytochemical Studies and Bioactivities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- TGF-β signaling in diseases
- Virus-based gene therapy research
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrhythmias and Treatments
- Rheumatoid Arthritis Research and Therapies
- Venous Thromboembolism Diagnosis and Management
Shanghai Sixth People's Hospital
2008-2024
Shanghai Jiao Tong University
2008-2024
Jinan Central Hospital
2024
Shandong First Medical University
2024
First Affiliated Hospital of Fujian Medical University
2014-2024
Fujian Medical University
2014-2024
Binzhou University
2018-2023
Binzhou Medical University
2012-2023
Tianjin haihe hospital
2022-2023
Center for Devices and Radiological Health
2023
Vinca alkaloids are widely used in cancer treatment for their ability to target microtubule dynamics. While efficacy treating certain cancers is well-established, the full spectrum of adverse event profiles remains an area ongoing research.
Background —Heterogeneous electrophysiological properties, which may be due in part to autonomic innervation, are important the maintenance of atrial fibrillation (AF). We hypothesized that heterogeneous sympathetic denervation with phenol would create a milieu for sustained AF. Methods and Results —After determination baseline inducibility, 15 dogs underwent epicardial application 11 sham procedure. After 2 weeks recovery, animals had repeat attempts at inducing AF effective refractory...
ARG1, which encodes Arginase1, is expressed in the liver cytoplasm and plays a major role hepatic urea cycle. The past research works shed light on fact that ARG1 participates anti-inflammation, tumor immunity, immunosuppression-related diseases. Nevertheless, concrete clinical significance of progression hepatocellular carcinoma (HCC) remain unclear. Herein, we aimed at examining expression clinicopathological HCC, together with determining effect metastasis HCC. In current study,...
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation and inflammation, in which growth factors are significantly involved. The extracellular signal-regulated p38 MAPK pathways play important roles the regulation of osteogenic chondrogenic differentiation bone marrow mesenchymal stem cells (BMSCs). However, exact mechanism remains unclear.In this study, human BMSCs was initiated micromass culture presence TGF-β1 for 14 days. Quantitative RT-PCR...
Background: Previous studies have indicated that childhood maltreatment (CM) may potentially influence the clinical symptomatology of obsessive-compulsive disorder (OCD). Here, we aimed to quantify relationship between CM and symptoms (OCS) depressive in OCD through a meta-analysis. Method: We searched PubMed, Embase, Cochrane Library, PsycARTICLES databases for articles reporting association on April 15, 2020. Random-effect models were used severity OCS OCD. Results: Ten records with 1,611...
Abstract Background The importance of inflammation in thrombosis is increasingly appreciated. Neutrophil-lymphocyte ratio (NLR) and monocyte to high-density lipoprotein (MHR) are important indicators systemic inflammation. This study aimed investigate the associations between NLR MHR with left atrial appendage thrombus (LAAT) spontaneous echo contrast (SEC) patients non-valvular fibrillation. Methods retrospective, cross-sectional enrolled 569 consecutive Multivariable logistic regression...
Abstract Background Neutrophil–lymphocyte ratio (NLR), monocyte-lymphocyte (MLR), and platelet-lymphocyte (PLR) are blood indicators of systemic inflammation. This study aims to compare the levels inflammatory derived from routine tests between adolescents with non-suicidal self-injury (NSSI) those non-NSSI. Methods A total 201 mood or emotional disorders were enrolled in this study, among which 106 had engaged NSSI 95 never NSSI. NLR, MLR, PLR calculated based on complete cell count....
To investigate the effects of ghrelin on delayed gastrointestinal transit in alloxan-induced diabetic mice.A mouse model was established by intraperitoneal injection with alloxan. Mice were randomized into two main groups: normal mice group and treated at doses 0, 20, 50, 100 200 mug/kg ip. Gastric emptying (GE), intestinal (IT), colonic (CT) studied after they had a phenol red meal following ghrelin. Based most effective dosage, atropine given 1 mg/kg 15 min before for each measurement. The...
Previous studies have suggested that dietary salt intake affects atrial fibrillation (AF); however, the causal association between them still remains unclear. Thus, we conducted this Mendelian randomization (MR) study to explore correlation them.Genetic instruments for were from a genome-wide (GWAS), which included 462,630 European individuals. Summary-level data AF obtained another published GWAS (22,068 cases and 116,926 controls). The inverse-variance weighting (IVW) method was performed...
The aim of this study was to investigate the effects and possible mechanisms ghrelin receptor (GHS-R) deficiency on gastric motility in GHS-R deficient (Ghsr-/-) mice. Ghsr-/- control (Ghsr+/+) mice were genotyped by PCR. percentage emptying (GE%) calculated following intraperitoneal adminis-tration ghrelin. In vitro, contractile response smooth muscle strips electrical field stimulation (EFS) intraluminal pressure change isolated stomach carbachol observed an organ bath. staining nerve...
strips taken from diabetic mice.RT-PCR confirmed the presence of GHS-R mRNA in strip preparations.CONCLUSION: Ghrelin and GHRP-6 increase gastric emptying mice with gastroparesis, perhaps by activating peripheral cholinergic pathways enteric nervous system.
Our study aims to investigate the impact of miR-224 on cell migration and invasion in colorectal cancer (CRC) as well its molecular mechanisms. The results showed that was significantly upregulated CRC compared normal tissues via TCGA database. Overexpression promoted invasion, while inhibition demonstrated opposite result transwell assays. In addition, we found BTRC a target gene through miRecords database dual-luciferase assay, western blot together with RT-qPCR led elevated expression...
Abstract Background The purpose of this study was to explore the efficacy and safety high intensity focused ultrasound (HIFU) in gastric cancer with liver metastasis (GCLM) patients who were contraindicated for either hepatectomy or radiofrequency ablation (RFA). Methods This is a prospective, observational on GCLM 1–3 metastases. primary lesions thoroughly resected any case that exhibited extra-hepatic excluded. A 1:2:2 propensity score-matching analysis performed using logistic regression...
Ghrelin receptor has been shown to be expressed along the human gastrointestinal tract. Recent studies showed that ghrelin and a synthetic agonist improved weight gain lean body mass retention in rat model of cancer cachexia by acting on receptor, is, growth hormone secretagogue (GHS-R). This study aims explore expression distribution tract cancers investigate possible involvement ghrelin-GHS-R system digestive cancers. Surgical specimens were obtained from various portions different...
The present study aimed to quantitatively determine the aberrant methylation signal of adenomatous polyposis coli (APC) gene in hepatocellular carcinoma (HCC), and evaluate whether hypermethylation APC promoter could be a prognostic biomarker for HCC. Taqman probe‑based quantitative methylation‑specific polymerase chain reaction was performed identify levels 57 HCC corresponding non‑tumorous liver tissues. In study, level upregulated by 4.51‑fold tissues compared with non‑cancerous...
Cancer-associated fibroblasts (CAFs) are the major constituents of tumor microenvironment and promote cancer development via tumor-stromal interactions. The alteration microRNA (miRNA) expression in can induce phenotype conversion between normal CAFs certain types. However, mechanisms underlying colorectal (CRC) largely unknown. Our study focuses on role miR-1246 fibroblasts-CRC cells interaction. In this study, CCD-18Co were cultured conditioned medium (CM) derived from CRC to obtain CAF...
Abstract Background Previous neuroimaging studies have extensively demonstrated many signs of functionally spontaneous local neural activity abnormalities in bipolar disorder (BD) patients using resting‐state functional magnetic resonance imaging (rs‐fMRI). However, how to identify the changes voxel‐wise whole‐brain connectivity pattern and its corresponding remain largely unclear BD patients. The current study aimed investigate patterns publicly available data from UCLA CNP LA5c Study....
Minimal hepatic encephalopathy (MHE) has a substantial impact on the clinical outcomes and quality of life (QOL) patients with cirrhosis. However, timely diagnosis intervention are challenging due to sophisticated diagnostic methods. In this study, 673 healthy controls 905 cirrhosis were screened, 660 757 cirrhosis, divided into test (292 patients) validation (465 cohort, analyzed after screening. A model Stroop (Stroop-CN) was constructed by multivariate linear regression based results...