A5071298370- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Cerebrovascular and Carotid Artery Diseases
- Genetic factors in colorectal cancer
- Coastal wetland ecosystem dynamics
- Pediatric health and respiratory diseases
- Plant Virus Research Studies
- Lung Cancer Treatments and Mutations
- Acute Ischemic Stroke Management
- Colorectal Cancer Treatments and Studies
- Breastfeeding Practices and Influences
- Artificial Intelligence in Healthcare and Education
- Plant responses to water stress
- Traumatic Brain Injury and Neurovascular Disturbances
- Gut microbiota and health
- Infant Nutrition and Health
- Synthesis of Tetrazole Derivatives
- Marine and coastal plant biology
- Ferroptosis and cancer prognosis
Tianjin Medical University
2018-2025
Second Hospital of Tianjin Medical University
2018-2025
Peking University
2021-2025
Peking University Cancer Hospital
2021-2025
Inner Mongolia Medical University
2015-2024
Suzhou Municipal Hospital
2024
Nanjing Medical University
2024
Purdue University West Lafayette
2023
Mongolian National University of Medical Sciences
2023
Peking Union Medical College Hospital
2023
Abstract To compare gut microbiota of healthy infants that were exclusively breast-fed or formula-fed, we recruited 91 infants, who assigned into three different groups and fed by breast milk (30 babies), formula A babies) B (31 for more than 4 months after birth. Faecal bacterial composition was tested. Among groups, α diversity lower in group formula-fed 40 days age, but increased significantly 6 age. The Bifidobacterium represented the most predominant genus Enterobacteriaceae second all...
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data showed the promising antitumor activity of afatinib EGFR-overexpressing ESCC. This proof-of-concept, phase II trial assessed efficacy and safety pretreated metastatic ESCC patients (n = 41) with EGFR overexpression (NCT03940976). The study met its primary endpoint, a confirmed objective...
Hashimoto's thyroiditis (HT) is the main cause of hypothyroidism. We develop a deep learning model called HTNet for diagnosis HT by training on 106,513 thyroid ultrasound images from 17,934 patients and test its performance 5051 2 datasets static 1 dataset video data. achieves an area under receiver operating curve (AUC) 0.905 (95% CI: 0.894 to 0.915), 0.888 (0.836-0.939) 0.895 (0.862-0.927). exceeds radiologists' accuracy (83.2% versus 79.8%; binomial test, p < 0.001) sensitivity (82.6%...
Immune checkpoint inhibitors (ICIs) have dramatically improved survival in advanced gastrointestinal (GI) cancer patients, but also resulted immune-related adverse events (irAEs). This study aimed to evaluate serological biomarkers of irAEs and treatment response GI patients.Metastatic patients were enrolled between August 1, 2015, July 31, 2017. Serum samples collected at baseline, a panel 59 serum was tested. The occurrence analyzed, biomarker expression correlated with irAE incidence...
Background Immune checkpoint inhibitors (ICIs) have significantly improved patient survival in multiple cancers. However, therapy response esophageal cancer is limited to subgroups of patients and clinically useful predictive biomarkers are lacking. Methods We collected a series plasma samples from 91 with before after ICI treatment. The Olink Immuno-Oncology panel (92 proteins) proximity extension assays was used detect the dynamic changes potential associated treatment outcomes. screened...
Abstract The association between genetic variations and immunotherapy benefit has been widely recognized, while such evidence in gastrointestinal cancer remains limited. We analyzed the genomic profile of 227 immunotherapeutic patients treated with immunotherapy, from Memorial Sloan Kettering (MSK) Cancer Center cohort. A immune prognostic signature (GIPS) was constructed using LASSO Cox regression. Based on this signature, were classified into two subgroups distinctive prognoses ( p <...
Immune checkpoint inhibitors (ICIs) benefit only a subset of patients in advanced esophageal squamous cell carcinoma (ESCC). Our study aims to develop and validate clinically accessible model better identify those who may respond ICIs. This enrolled ESCC treated with ICIs at Peking University Cancer Hospital from January 14, 2016, 26, 2024 for the training cohort Harbin Medical between 10, 2019, July 6, 2022 validation cohort. Combined positive score (CPS) was recorded assess predictive...
The aim of this study was to establish a model for predicting the probability malignancy in solitary pulmonary nodules (SPNs) and provide guidance diagnosis follow-up intervention SPNs.We retrospectively analyzed clinical data computed tomography (CT) images 294 patients with clear pathological SPN. Multivariate logistic regression analysis used screen independent predictors SPN SPNs. Then, another 120 who did not participate establishment were chosen as group B verify accuracy prediction...
With the expanding use of immune checkpoint inhibitors (ICIs) in gastrointestinal (GI) cancer, occurrence acquired resistance (AR) has gradually emerged. However, progression patterns and survival patients with AR to ICIs are still unknown.To explore characteristics prognosis after ICI therapy advanced GI cancer.This cohort study screened cancer treated between January 14, 2016, December 31, 2020, at Peking University Cancer Hospital. Initial response was defined as complete response,...
Immunotherapy has emerged as an effective therapeutic strategy for various cancers, including colorectal cancer (CRC), but only a subset of MSI-H patients can benefit from such therapy. Patched1 (PTCH1) is frequently altered gene in CRCs and its mutations contribute to unregulated Hedgehog (Hh) signaling. In the study, we evaluated association PTCH1 with CRC immunity based on our single-center cohort multiple genomic datasets. Among 21 enrolled patients, six (28.6%) harbored mutation WES...
To compare the gut microbiota of healthy infants based on specific interactions delivery modes and feeding types, we recruited 62 babies who were followed up for 2 years from our previous cohort study 91 (the rest lost to follow-up). They exclusively fed breast milk or formulas more than 4 months after birth. The fecal bacterial composition was tested at 40 days, 3 months, 6 age. Solid foods introduced age thus did not affect before According different (i.e., vaginal delivery, VD, cesarean...
Objective: Large volume radiological text data have been accumulated since the incorporation of electronic health record (EHR) systems in clinical practice. We aimed to determine whether deep natural language processing algorithms could aid radiologists improving thyroid cancer diagnosis. Methods: Sonographic EHR were obtained from database. Pathological reports used as gold standard for diagnosing cancer. developed diagnosis based on (THCaDxNLP) interpret unstructured sonographic area under...
Immune checkpoint inhibitors (ICIs) have achieved remarkable results in cancer treatments. However, there is no effective predictive biomarker for gastrointestinal (GI) cancer.
Introduction: Multimodal imaging agent has the potential to overcome shortage and incorporate advantages of different tools for extremely sensitive diagnosis. To achieve multimodal imaging, combining multiple contrast agents into a special nanostructure become main strategy; However, combination all these functions one nanoplatform usually requires complicated synthetic procedure that results in heterogeneous nanostructure. Methods: In this study, we develop ultrasmall gold nanoclusters with...
Abstract To assess the Alberta Stroke Program Early CT Score (ASPECTS) screening tool for effectiveness in endovascular treatment of late time window stroke with large vessel occlusion. A retrospective analysis was performed individuals administered our neurology department between 2016 and 2020 ischemic induced by acute occlusion anterior circulation ASPECTS ≥ 6. Detailed baseline data were collected. Patients assigned to 2 groups based on onset time, including 0–6 h (treated within 6...
Abstract Background Iatrogenic pseudoaneurysms arising from the internal carotid artery subsequent to endarterectomy are exceptionally infrequent. Herein, we present a case detailing an pseudoaneurysm that manifested hybrid and endovascular therapy intervention. Our approach managing this condition involved novel technique wherein thrombin was directly injected into luminal cavity of under guidance C-arm. Case presentation A 66-year-old male patient Chinese ethnicity exhibited 4-month...
<title>Abstract</title> <bold>Introduction</bold> The efficacy of immune checkpoint inhibitors (ICIs) for advanced esophageal squamous cell carcinoma (ESCC) remains suboptimal. This study aims to construct and validate a clinically accessible model better identify populations that may potentially benefit from ICIs. <bold>Methods</bold> enrolled ESCC patients treated with ICIs at Peking University Cancer Hospital January 14, 2016, 26, 2024, forming the training cohort. Combined positive score...
To investigate the development present situation of department critical care medicine in Inner Mongolia Autonomous Region (hereinafter referred to as Mongolia), order promote standardized and homogeneous Mongolia, also provide a reference for discipline construction resource allocation.A survey study was conducted comprehensive intensive unit (ICU) tertiary secondary hospitals by online questionnaire telephone data verification. The based on Guidelines Construction Management Intensive Care...