A5101969449- Cancer Immunotherapy and Biomarkers
- Advancements in Transdermal Drug Delivery
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- Pleural and Pulmonary Diseases
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Essential Oils and Antimicrobial Activity
- Bone health and treatments
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Extracellular vesicles in disease
- Hair Growth and Disorders
- AI in cancer detection
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cell death mechanisms and regulation
Nanjing Tech University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Shanxi Province Hospital of Traditional Chinese Medicine
2024
Peking University Third Hospital
2020-2024
Peking University
2020-2024
Northeastern University
2022-2023
Shanghai Jiao Tong University
2016-2023
Shanghai Ninth People's Hospital
2020-2023
China-Japan Friendship Hospital
2023
Tianjin Medical University Cancer Institute and Hospital
2018-2022
How to improve effective accumulation and intratumoral distribution of plasmonic gold nanoparticles has become a great challenge for photothermal therapy tumors. Herein, we reported nanoplatform with therapeutic effects by fabricating Au nanorods@SiO2@CXCR4 loading the prepared into human induced pluripotent stem cells(AuNRs-iPS). In virtue prominent optical properties remarkable tumor target migration ability iPS cells, nanorods delivery mediated cells via AuNRs-iPS was found have prolonged...
Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD).However, our understanding immune subtyping LUAD and its association with clinical response inhibitor remains incomplete.Here we performed molecular analysis from Cancer Genome Atlas (TCGA) validated findings TCGA cohort in 9 independent validation cohorts.We conducted consensus nonnegative matrix factorization (NMF).Potential ICB therapy was estimated Tumor...
Herein, a visual electrochemiluminescence (ECL) luminophore, 6-azido-2-thioxanthine-coated gold nanoclusters (ATT-Au NCs), was prepared efficiently in single step, followed by comprehensive characterization of their structural, optical, and ECL properties using diverse analytical methodologies. Concurrently, nanoparticles, dimers, nanorod (Au NR) dispersions, dimers (parallel perpendicular conformations) were synthesized via chemical reduction, DNA ligation, seed growth, electrostatic...
Nanocarriers capable of circumventing various biological barriers between the site administration and therapeutic target hold great potential for cancer treatment. Herein, a redox‐sensitive, hyaluronic acid‐decorated graphene oxide nanosheet (HSG) is developed tumor cytoplasm‐specific rapid delivery using near‐infrared (NIR) irradiation controlled endo/lysosome disruption redox‐triggered cytoplasmic drug release. Hyaluronic acid (HA) modification through redox‐sensitive linkages permits HSG...
Abstract The foundation of regenerative medicine is the investigation and progression hypotheses approaches for substituting, mending, reconstructing, or regenerating different tissues organs within human body. Nevertheless, due to slender central segment entire unattached configuration meniscus, efficacy conventional therapies unsatisfactory in reinstating meniscal health functionality. To overcome these limitations, medical‐type hydrogels have potential provide a solution meniscus repair...
In recent years, nanoparticles (NPs) including nanostructured lipid carries (NLC) and solid (SLN) captured an increasing amount of attention in the field transdermal drug delivery system. However, mechanisms penetration enhancement transport properties NPs are not fully understood. Therefore, this work applied different platforms to evaluate interactions between skin loading triptolide (TPL, TPL-NLC TPL-SLN). Besides, labeled with fluorescence probe were tracked after administration...
This work aimed to provide useful information on the use of nanoemulsions for percutaneous administration triptolide. Lipid nanosystems have great potential transdermal drug delivery. Nanoemulsions and nanoemulsion gels were prepared enhance permeation. Microstructure in vitro/in vivo delivery characteristics triptolide (TPL)-nanoemulsions TPL-nanoemulsion compared. The integrity during its effects surface skin also investigated. penetration mechanisms investigated by differential scanning...
Abstract H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how triggers carcinogenesis still not clear. In this study, neutrophils and relative markers in cancer development were examined with immunohistochemistry fluorescence RNA situ hybridization methods. On average, 24 times more found tissues about 9 intestinal metaplasia comparing to normal tissue controls. CagA + pylori infection adjacent or EBV did increase neutrophil...
Immune checkpoint blockade (ICB) therapy has achieved remarkable clinical benefit in melanoma. However, our understanding of biomarkers that predict response to ICB remained obscure. Here we systematically analyzed the association between somatic mutations profile and clinicopathologic information from 336 melanoma patients treated by (CTLA-4/PD-1). We identified eight new significantly mutated genes including COL5A1, SEMA3E, COL28A1, DGKG, RAPGEF5, GLDN, NCF2 RCAN2. A mutational signature...
Abstract Background Smart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority previously reported MnO 2 nanostructures are nanoparticles, nanosheets, or nanocomposites incorporated with other types which may not most effective method for loading therapeutic payloads. Previous studies have designed nanoshells achieve tumor-specific enhanced combination...
// Ping Chen 1, 2, 3, 4 , Tao Hu Yupei Liang 1 Yanan Jiang 3 Yongfu Pan Chunjie Li Zhang Dongping Wei Pei Lak Shin Jeong 5 Yiwei Chu Hui Qi 6, 7 Meng Yang Robert M. Hoffman 7, 8 Ziming Dong Lijun Jia Cancer Institute, Fudan University Shanghai Center, Department of Oncology, Medical College, University, Shanghai, China 2 College Basic Sciences, Zhengzhou Zhengzhou, Immunology, Collaborative Innovation Center Henan Province for Chemoprevention, Pharmacy, Seoul National Seoul, Korea 6...
Parathyroid hormone-related protein (PTHrP) possesses a variety of physiological and developmental functions is also known to facilitate the progression many common cancers, notably their skeletal invasion, primarily by increasing bone resorption. The purpose this study was determine whether PTHrP could promote epithelial-to-mesenchymal transition (EMT), process implicated in cancer stem cells that critically involved invasion metastasis. EMT observed DU 145 prostate stably overexpressing...
Abstract Background The glucose-6-phosphatase catalytic subunit (G6PC) is a key enzyme that involved in gluconeogenesis and glycogen decomposition during glycometabolism. Studies have shown G6PC abnormally expressed various cancers participates the proliferation metastasis of tumors. However, role cervical cancer remains poorly established. Methods To analyze expression tissues patients by immunohistochemistry. Effects deregulation on phenotype were determined using MTT, colony formation,...