Cardiovascular disease (CVD) prevalence has increased continuously over the last 30 years in China. Dyslipidemia is an important modifiable risk factor CVD. We aimed to collect current data on of dyslipidemia northern China and explore potential influencing factors.In this cross-sectional study, we selected a representative sample 65,128 participants aged ≥35 Inner Mongolia during 2015-2017. All completed questionnaire were examined for factors. was defined according 2016 Chinese guidelines...

Abstract Background Birth Defects are a series of diseases that seriously affect children's health. defects generally caused by several interrelated factors. The aims the article is to estimate prevalence rate and types birth in Inner Mongolia, China, compare socio-demographic characteristics among children with analyze association between risk factors defects. Methods Data used this study were obtained through baseline survey Mongolia Program, population-based conducted from 2005 2008....

Groundwater is an important natural resource of drinking water in rural areas Inner Mongolia, China. In this study, 4438 groundwater samples were collected from the 81 counties and analyzed for 16 parameters, including pH, total hardness (TH), chemical oxygen demand (COD), dissolved solids (TDS), sulfate (SO42-), chloride (Cl-), fluoride (F-), iron (Fe), manganese (Mn), arsenic (As), cadmium (Cd), hexavalent chromium (Cr), lead (Pb), aluminum (Al), cuprum (Cu), zinc (Zn). The quality was...

To explore the difference of glucose fluctuations between normal subjects and diabetes mellitus (DM) patients their impact on development CAD in type 2 DM patients.The were divided into 3 groups: control (group A, n = 40), without cardiovascular complications B, 56), with C, 92). The SYNTAX scores collected group C. CGMS for 72 h was applied all subjects. indexes such as MBG LAGE calculated. Glycemic excursions compared groups respectively.The tested had significant differences among three...

Rare earth elements (REEs) have been broad application in a range of industries, including the electronics industry, advanced materials, and medicine. However, health risks associated with REEs received increasing attention. 31 residents (16 males 15 females) from Bayan Obo mining Inner Mongolia, China, were enrolled this study. In total, 677 food samples, major human exposure matrices (drinking water duplicate diets), bio-samples (urine blood) participants obtained. The concentrations...

Both diabetes and hyperinsulinemia are confirmed risk factors for Alzheimer's disease. Some researchers proposed that antidiabetic drugs may be used as disease-modifying therapies, such metformin thiazolidinediones, although more evidence was poorly supported. The aim of the current study is to investigate role in Aβ-induced cytotoxicity explore underlying mechanisms. First, experimental results show salvaged neurons exposed Aβ a concentration-dependent manner with MTT LDH assay. Further,...

Approximately half of recurrent miscarriages have unexplained etiology. Recent evidences suggest that cytokines are important determinants in pregnancy maintenance and as such, cytokine gene polymorphisms, which can affect production and/or functionality, could play a role the disorder. Thus, we aimed to investigate association selected polymorphisms with risk miscarriage among Chinese.TNF -238G > A, TNF -308G IL1B -511 T C, 3954C T, IL6 -174G -634C G, IL10 -1082A G IFNG 874A were genotyped...

The aim of this study was to establish a model for predicting the probability malignancy in solitary pulmonary nodules (SPNs) and provide guidance diagnosis follow-up intervention SPNs.We retrospectively analyzed clinical data computed tomography (CT) images 294 patients with clear pathological SPN. Multivariate logistic regression analysis used screen independent predictors SPN SPNs. Then, another 120 who did not participate establishment were chosen as group B verify accuracy prediction...

The aim of this study was to observe the regulatory action polo-like kinase 1 (PLK1) gene in invasion anaplastic thyroid carcinoma cells and investigate its mechanisms. expression PLK1 protein 36 patients with detected by immunohistochemical staining. siRNA against designed, synthesized transfected into ARO cells. effects on cell were a soft agar colony formation assay Transwell chamber assay. corresponding using western blot analysis. samples (67.5±10.6%) significantly higher compared that...

SUMMARY The presence or absence of spines is an important economic trait cucumber fruit. Spines are believed to be a type specialized trichome on the fruit surface, and all identified trichome‐less mutants lack spines. However, genes that specifically regulate spine initiation remain identified. Here, we found knocking out TARGET OF EAT3 homolog ( CsTOE3 ), belonging APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) family, affected flower development and, more interestingly, inhibited initiation....

Brucellosis, a zoonosis which can seriously harm public health. Inner Mongolia is known as an endemic region of human brucellosis in China. The aim this study to present the epidemic from 2010 2014, and provide evidence preventing areas. included 838,956 participants by cluster random sampling 2014. contents questionnaire survey serological testing. seropositive rate was calculated based on testing results, tested determine whether were infected brucellosis. new cases diagnosed using data...

Background: Chronic Kidney Disease (CKD) is a common chronic disease that threat to human health. Accumulating evidence showed long noncoding RNAs (lncRNAs) are associated with various diseases and can function as competing endogenous (ceRNAs). However, the roles functions of lncRNA‒miRNA-mRNA network in CKD still unclear. Methods: In this study, we performed differential expression analysis lncRNAs, miRNAs, mRNAs using datasets GSE66494 GSE80247 from Gene Expression Omnibus. A total 33 20...

Background: The purpose of this multicenter study was to investigate the accuracy a real-time continuous glucose monitoring sensor in Chinese diabetes patients. Subjects and Methods: In total, 48 patients with type 1 or 2 from three centers China were included study. MiniMed Paradigm® 722 insulin pump (Medtronic, Northridge, CA) used monitor changes blood levels for successive days. Venous subjects randomly collected every 15 min seven consecutive hours on day when wearing sensor. Reference...

Abstract Coumarins isolated from Hydrangea paniculata (HP) had a renal protective effect in experimental membranous nephritis (MN), but the mechanisms are not clear. Currently, we investigate whether modulation of gut dysbiosis by HP contributes to its protection. Experimental MN rats were treated with for six weeks. Fecal 16S rDNA sequencing and metabolomics performed. microbiota transplantation (FMT) was used evaluation study. The results demonstrate that deteriorated function found rats,...

Abstract Background The oxidative stress resulting from increased production of ROS plays a crucial role in the development diabetic complications. We aim to explore relationships between stress, nephropathy (DN) and short-term insulin pump intensive therapy (insulin therapy). Methods Levels 8-hydroxy-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), glutathione (GSH), superoxide dismutase (SOD) Interleukin-6 (IL-6) were estimated before after 2 weeks normal group (NC) type (DM) with...

This study aimed to describe the frequency and temporal profile of acute cerebral infarction (ACI) using a continuous glucose monitoring system (CGMS) in patients with without type 2 diabetes mellitus (T2DM) explore impact blood fluctuations on short-term prognosis ACI.The subjects were divided into four groups: T2DM (DMCI, Group A, n=56); (DM-NCI, B, n=36); Acute (NDM-CI, C, n=54); Healthy control group (NG, D, n=36). The National Institutes Health Stoke Scale (NIHSS) modified Rankin scale...

Abstract Background Hypertension has always been a worldwide health concern. The purpose of this study was to investigate the prevalence, awareness, treatment, and control rates hypertension among adult residents northern China, where people usually have high-fat, high-salt diet heavy alcohol consumption. Methods Through Early Screening Comprehensive Intervention Project for High Risk Groups Cardiovascular Diseases in Inner Mongolia we collected data 70,380 residents, from September 2015...

Abstract Objectives To assess the impact of cardiovascular disease (CVD) risk factor control on health-related quality life (HRQoL), as well other influencing factors HRQoL among high CVD individuals. Methods From 2015 to 2017, residents six villages or communities in Inner Mongolia, selected using a multi-stage stratified cluster random sampling method, were invited complete questionnaire and undergo physical examination laboratory testing. We participants whose predicted 10-year for...

Diabetic nephropathy (DN) is the most common microvascular complication of diabetes and one major causes end-stage renal disease (ESRD). Cilostazol, an antiplatelet drug, plays important role in prevention treatment chronic complications through a series mechanisms, including anti-inflammation, inhibition vascular smooth muscle proliferation, protection nerve cells, regulation blood lipids. In this study, we observed effects cilostazol on serum soluble cell adhesion molecule-1 (sICAM-1)...