A5048270022- Gut microbiota and health
- Lysosomal Storage Disorders Research
- Acute Lymphoblastic Leukemia research
- Berberine and alkaloids research
- Multiple Myeloma Research and Treatments
- Parasitic Diseases Research and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Synthesis and Biological Activity
- Diabetes Treatment and Management
- Cancer Cells and Metastasis
- Clostridium difficile and Clostridium perfringens research
- Acute Kidney Injury Research
- Cancer therapeutics and mechanisms
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Histone Deacetylase Inhibitors Research
- Cancer Immunotherapy and Biomarkers
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Abstract Coumarins isolated from Hydrangea paniculata (HP) had a renal protective effect in experimental membranous nephritis (MN), but the mechanisms are not clear. Currently, we investigate whether modulation of gut dysbiosis by HP contributes to its protection. Experimental MN rats were treated with for six weeks. Fecal 16S rDNA sequencing and metabolomics performed. microbiota transplantation (FMT) was used evaluation study. The results demonstrate that deteriorated function found rats,...
Dynamic changes in gut dysbiosis and metabolomic dysregulation are associated with immune-complex glomerulonephritis (ICGN). However, an in-depth study on this topic is currently lacking. Herein, we report ICGN model to address gap. was induced via the intravenous injection of cationized bovine serum albumin (c-BSA) into Sprague-Dawley (SD) rats for two weeks, after which mycophenolate mofetil (MMF) losartan were administered orally. Two six weeks establishment, fecal samples collected 16S...
Abstract BACKGROUND: Immunotherapy has become the fastest-adopting treatment paradigm for lung cancer with improved survival. By binding its ligand (ICOSL), an inducible T-cell co-stimulator (ICOS) could contribute to reversing immunosuppression and improving immune response thus be a potential target immunotherapy. METHODS: We selected 54 formalin-fixed, paraffin-embedded tumor tissues from cases stage I-III adenocarcinoma cancer. Immunohistochemical expression of ICOS ICOSL were evaluated....