A5030391503- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- HER2/EGFR in Cancer Research
- COVID-19 and healthcare impacts
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Inflammatory mediators and NSAID effects
- Genetic factors in colorectal cancer
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Single-cell and spatial transcriptomics
- Colorectal and Anal Carcinomas
West China Hospital of Sichuan University
2024-2025
Sichuan University
2024-2025
Guangzhou Medical University
2025
State Key Laboratory of Respiratory Disease
2025
Capital Medical University
2013-2024
Beijing Shijitan Hospital
2021-2024
Fujian University of Traditional Chinese Medicine
2024
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Hebei Provincial Center for Disease Control and Prevention
2024
Abstract Dual-specificity phosphatase 6 (DUSP6) serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). We previously identified Dusp6 as regenerative repressor during zebrafish heart regeneration, therefore we propose to investigate role this in mammalian cardiac repair. Utilizing rat strain harboring nonsense mutation, neutrophil-cardiomyocyte co-culture, bone marrow transplanted rats neutrophil-specific knockout mice, find...
To investigate the early dynamic changes of biomarkers associated with capillary leak syndrome (CLS) in patients severe acute pancreatitis (SAP) and their correlation multiple organ failure (MOF). A total 171 SAP admitted to West China Centre Excellence for Pancreatitis, Hospital, Sichuan University between September 1, 2019 December 31, 2020 were enrolled this study. The divided into MOF non-MOF groups based on occurrence first 5 days hospitalization, further subgroups presence...
Background Immune checkpoint inhibitors (ICIs) have significantly improved patient survival in multiple cancers. However, therapy response esophageal cancer is limited to subgroups of patients and clinically useful predictive biomarkers are lacking. Methods We collected a series plasma samples from 91 with before after ICI treatment. The Olink Immuno-Oncology panel (92 proteins) proximity extension assays was used detect the dynamic changes potential associated treatment outcomes. screened...
As immune regulatory and effector cells, monocytes play an important role in the blood-extracorporeal circuit contact-related acute lung injury patients undergoing cardiopulmonary bypass (CPB). However, circulating are phenotypically functionally heterogeneous, so we characterised how immature affect induced by CPB.The identification dynamic changes monocyte subsets were monitored flow cytometry CPB a rat model of CPB. The differentiation migration explored vitro cultures adoptive transfer...
<h3>Objective:</h3> Currently, there is an urgent need to identify immunotherapeutic biomarkers increase the benefit of immune checkpoint inhibitors (ICIs) for patients with gastric cancer (GC). Homologous recombination deficiency (HRD) can modify tumor microenvironment by increasing presence tumor-infiltrating lymphocytes and therefore might serve as a biomarker response. We aimed analyze mutational pattern HR-associated genes in Chinese GC its relevance profile clinical <h3>Methods:</h3> A...
Background: Microsatellite-stable (MSS) colon adenocarcinoma (COAD) patients are not sensitive to immune checkpoint inhibitors. Here, we focused on analyzing the relationship between homologous recombination repair (HRR)-related gene mutations and clinical immunotherapy responses in MSS COAD. Methods: The mutational landscape was profiled a cohort of 406 Chinese COAD via next-generation sequencing (NGS). Correlations HRR tumor immunity or outcomes two genomic datasets were analyzed...
ABSTRACT Background Vascular calcification (VC) commonly occurs and seriously increases the risk of cardiovascular events mortality in patients with hemodialysis. For optimizing individual management, we will develop a diagnostic multivariable prediction model for evaluating probability VC. Methods The study was conducted four steps. First, identification miRNAs regulating osteogenic differentiation vascular smooth muscle cells (VSMCs) calcified condition. Second, observing role miR-129–3p...
Minimal residual disease (MRD) detection is an important prognostic parameter in patients with refractory or relapsed B-cell acute lymphoblastic leukemia (R/R B-ALL). CD79a has been reported to exhibit a high degree of linage-specificity for differentiation, specificity 88% and sensitivity 100%. In this study, we investigated the efficiency role cytoplasmic (cCD79a) antibody-gated multicolor flow cytometry (MFC) MRD B-ALL who received CD19-targeted chimeric antigen receptor (CAR) T-cell...
Previous studies have demonstrated that activation/expansion by certain cytokines as well recruitment specific chemokines is involved in enrichment of regulatory T (Treg) cells local tissues or organs under pathological conditions. Recent evidence indicates human Treg are a heterogeneous population comprises three distinct subpopulations: CD25 + CD45RA resting (rTreg) cells, hi − activated (aTreg) which both suppressive, and cytokine‐secreting with proinflammatory capacity. Moreover, rTreg...
Patients with breast cancer presenting single lymph node metastasis (from a sentinel node) experience prolonged survival compared to patients multiple metastases (≥3). However, little information is available on the genetic and immunological characteristics of within regional nodes as they progress from (SLN) downstream (MLNs).Genomic profiling was performed using next-generation sequencing panel covering 520 cancer-related genes in primary tumour metastatic 157 female cancer. We included...
Abstract Background The cancer-immunity cycle (CI cycle) provides a theoretical framework to illustrate the process of anticancer immune response. Recently, update CI theory emphasizes importance tumor’s immunological phenotype. However, there is lack phenotype pan-cancer based on theory. Methods Here, we applied visualizing method termed ‘cancer immunogram’ visualize state 8460 solid tumors from TCGA cohort. Unsupervised clustering cancer immunogram was performed using nonnegative matrix...
This study was performed to investigate the analgesic effects of intramuscular injection dezocine-based local anesthesia in patients undergoing inguinal hernia repair.A total 120 underwent herniorrhaphy from July 2015 December 2016 and were randomly divided into 2 groups: dezocine group, which a preoperative administered, control no administered. The patients' pain comfort levels evaluated at 30 minutes, hours, 6 12 24 hours postoperatively.The visual analog scale scores significantly lower...
This study was aimed to evaluate the feasibility and accuracy of real-time three-dimensional echocardiography (RT-3DE) measurement left atrial (LA) volume function in comparison with two-dimensional (2DE) measurements fibrillation (AF) patients.A total 50 pairs AF patients healthy controls were enrolled this study. Indexed LA end-diastole (ILAEDV) indexed end-systolic (ILAESV), as well indices such segmental ejection fraction (LAEF), assessed using 2DE Simpson's method RT-3DE method.The...
Background The goal of this study was to analyze serum from lymphangioleiomyomatosis (LAM) patients and healthy controls identify novel biomarkers that could shed light on disease diagnosis pathogenesis. Methods From April 2017 October 2019, qualified samples were obtained explore differences in 59 immune proteins between 67 LAM 49 by the Luminex method. Results We characterized 22 differentially expressed compared with people. Fifty-nine then classified into eight categories according their...
Full spectrum flow cytometry brings a breakthrough for minimal residual disease (MRD) detection in acute myeloid leukemia (AML). We aimed to explore the role of new panel MRD detection. established 24-color full-spectrum panel. A tube antibodies included CD45, CD117, CD34, HLA-DR, CD15, CD64, CD14, CD11c, CD11b, CD13, CD33, CD371, CD7, CD56, CD19, CD4, CD2, CD123, CD200, CD38, CD96, CD71, CD36, and CD9. discovered that when meets 26 parameters (24 colors), these markers were not only limited...
Abstract Background Pancreatic adenocarcinoma (PAAD) is a nonimmunogenic tumor, and very little known about the relationship between host immune response patient survival. We aimed to develop an prognostic model (IPM) analyze its relevance tumor profiles of patients with PAAD. Methods investigated differentially expressed genes normal tissues in TCGA PAAD cohort. Immune-related were screened from highly variably weighted gene correlation network analysis (WGCNA) construct IPM. Then,...
4076 Background: Patients with microsatellite instability-high (MSI-H) colonic adenocarcinoma (COAD) are always immunotherapy-sensitive for the use immune checkpoint inhibitors, however, vast majority of COAD patients (85%) stable (MSS). Homologous recombination deficiency (HRD) is demonstrated to be a response predictor immunotherapies in gynecologic cancers, while limited studies were reported colon cancer. We focus herein on mutational pattern HRR related genes large Chinese cohort and...
Background Anlotinib is a multi-targeted tyrosine kinase inhibitor mainly targeting angiogenesis signaling. The predictive marker of anlotinib’s efficacy remains elusive. This study was designed to explore the anlotinib in non-small cell lung cancer (NSCLC). Methods We prospectively enrolled 52 advanced NSCLC patients who underwent at least one line targeted therapy or chemotherapy between August 2018 and March 2020. Patients were divided into durable responders (DR) non-durable (NDR) based...