A5101890672- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- FOXO transcription factor regulation
- Peptidase Inhibition and Analysis
- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Signaling Pathways in Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Coronary Interventions and Diagnostics
- Iron Metabolism and Disorders
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- NF-κB Signaling Pathways
- Coronary Artery Anomalies
- Cancer, Stress, Anesthesia, and Immune Response
- Flavonoids in Medical Research
- Bone and Dental Protein Studies
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020-2025
Shanghai University of Traditional Chinese Medicine
2020-2025
Creative Commons
2021
Weatherford College
2021
Second Military Medical University
2011-2020
Yueyang Hospital
2020
Eastern Hepatobiliary Surgery Hospital
2017-2018
Zhongshan Hospital
2015
Fudan University
2015
Shanghai Changzheng Hospital
2005-2014
Tamoxifen is an inhibitor of estrogen receptors and was originally developed for breast cancer therapy. Besides, tamoxifen widely used Cre-estrogen receptor-mediated conditional knockout in transgenic mice. However, we found that the 3-month feeding 0.5 g/kg diet dramatically lowered body weight The liver fat content serum lipid indicators were all decreased. But injuries identified, as illustrated by liver/body ratio ALT AST levels. Sirius red staining α-SMA even showed fibrosis liver....
Cancer-associated fibroblasts (CAFs) play important roles in the occurrence and development of hepatocellular carcinoma (HCC) are a key component immunosuppressive microenvironment. However, origin CAFs has not been fully elucidated. We employed single-cell sequencing technology to identify dynamic changes different subsets at time points rat primary HCC model. Inflammation-associated (Pdgfrα+ CAFs) were subsequently identified, which demonstrated significant correlation with survival...
MASLD is a multifactorial disease with specific subtypes being featured by hepatic iron overload and loss of miR-122, liver-specific microRNA regulating lipid homeostasis. Previously we reported the mechanism decreasing miR-122. Interestingly, found that mice lacking miR-122 were highly sensitive to overload-induced steatosis fibrosis. The present study aimed disclose downstream mechanisms preventive measures targeting We first validated decreases in iron-related genes MASLD. By using...
Twist-related protein 1 (Twist1), also known as class A basic helix-loop-helix 38 (bHLHa38), has been implicated in cell lineage determination and differentiation. Previous studies demonstrate that Twist1 expression is up-regulated gastric cancer with poor clinical outcomes. Besides, suggested to be involved progression of human cancer. However, its biological functions remain largely unexplored. In the present study, we show Twist overexpression leads a significant up-regulation FoxM1,...
Current literature has demonstrated that host glutamine depletion facilitates tumorigenesis. Likewise, the transporter SLC38A1 is putatively associated with malignant transformation and tumor progression. Taken together, this forms premise for undertaking current study. The twofold aim of study was to provide insight into whether or not a variance in expression exists between human gastric cancer healthy tissues, determine how silencing gene could affect proliferation, viability, migration,...
Abstract Background Zinc is necessary for normal liver function; and vice versa, the plays a central role in zinc homeostasis. The aim of present study to assess effects repeated psychological stress (PS) on metabolism related mechanism involved homeostasis rat liver. Methods In study, we used communication box create PS model investigated serum corticosterone (CORT), level liver, metallothionein (MT) content ZRT/IRT-like Protein 14 (ZIP14) mRNA expression. Results results showed that CORT...
The occurrence, growth, and metastasis of colorectal cancer (CRC) are connected to the hypercoagulable state blood (CRC). This study aimed identify significant coagulation factors predict prognosis CRC.
Abstract Backgroud SPARC‐like protein 1 (SPARCL1), a member of extracelluar matrix glycoprotein, is involved in many physiological functions. Methods Tissue microarray (TMA) blocks were constructed based on 1,072 Chinese patients, containing both gastric cancer (GC) tissues and adjacent normal mucosa tissues. We analyzed the expression SPARCL1 from mRNA level, using Real‐time quantitative polymerase chain reaction (qRT‐PCR), semi‐quantitative PCR, immunohistochemistry (IHC), Western...
A-disintegrin and metalloproteinases (ADAMs) are members of a family multidomain transmembrane secreted proteins. Specific ADAMs upregulated in human cancers correlated with tumor progression poor outcome, but rarely studied hilar cholangiocarcinoma (HC). This study aimed to explore the expression profiles their potential underlying mechanisms promoting cancer progression.mRNA ADAM-9, - 10, 11, 12, 15, 17, 28, 33 was analyzed (HC) samples. Immunohistochemical (IHC) analysis used detect...
Hepatocellular carcinoma is the most common type of liver cancer. Radiotherapy combined with chemotherapy treatment choice for hepatocellular carcinoma, but radioresistance cancer remains a significant therapeutic hindrance. Here, we provided several lines evidence that small ubiquitin-like modifier (SUMO)-specific protease 6 (SENP6) could be an attractive molecular target carcinoma. By using immunohistochemical and real-time PCR, showed SENP6 was overexpressed in more than half tissues. The...
Abstract Background Crizotinib, an oral first-generation tyrosine kinase inhibitor (TKI), is superior to systemic chemotherapy for the treatment of non-small cell lung cancer (NSCLC) with positive rearrangement anaplastic lymphoma (ALK). However, increased incidence renal and hepatic cysts has been reported in patients on crizotinib treatment. Case presentation Here, we describe a case 71-year-old Chinese women developed multiple cystic lesions kidney liver during primary metastatic NSCLC....
ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health concern. However, there are limited effective treatments available for it. The use of natural products in the management and treatment HCC gaining more attention. Baicalein flavonoid compound that has been reported to have antitumor activities HCC. direct binding targets baicalein still unknown. Therefore, we used DNA‐programmed affinity labeling method identify target validated its function cells. We set blank...
Background Hepatocellular carcinoma (HCC) is a common gastrointestinal malignancy with high incidence and poor prognosis. Common treatment methods include surgery, transcatheter arterial chemoembolization (TACE), ablation, targeted therapy. In recent years, combination antiangiogenic therapy immune checkpoint inhibitors has made great progress in the of advanced HCC. Here, we report case patient HCC who achieved durable benefit from anti-vascular combined intratumoral cryoablation. Main Body...
To study the expression of aldo-keto reductase 1 member B1 (AKR1B1) in gastric carcinoma (GC), correlation between AKR1B1 and clinicopathological characteristics GC patients, provide reference for diagnosis prognosis patients. One hundred thirty-six patients with were collected, level adjacent tissues was detected by immunohistochemistry assays. The features collected to analyze relationship expression. positive significantly higher than that nontumor tissues. difference paired statistically...
Avasimibe is a bioavailable acetyl-CoA acetyltransferase (ACAT) inhibitor and shows good antitumor effect in various human solid tumors, but its therapeutic value cholangiocarcinoma (CCA) underlying mechanisms are largely unknown. In the study, we proved that avasimibe retard cell proliferation tumor growth of CCAs identified FoxM1/AKR1C1 axis as potential novel targets avasimibe. Aldo-keto reductase 1 family member C1 (AKR1C1) gradually increased along with disease progression highly...
We sought to reveal the status of phosphorylated 4E-binding protein 1 (p-4ebp1) expression in Chinese gastric cancer patients and its correlation with tumor prognosis.Tissue microarray blocks containing tissue matched noncancerous specimens from 286 were constructed. The (4ebp1) p-4ebp1 these was analyzed using immunohistochemical studies.The rates 4ebp1 68.5% (196 286) 49.7% (142 respectively. correlated node metastasis poor differentiation, while size, TNM stage. overexpression has a...
Limited published data about periprocedural myocardial injury (PMI) after successful chronic total occlusion (CTO)-percutaneous coronary intervention (PCI) were available. The study aimed to investigate risk predictors and clinical implications of PMI CTO-PCI drug-eluting stent (DES) implantation. Between 2009and 2012, a 437 patients who underwent recanalization with DESs included. All the cardiac troponin T (cTnT)-positive excluded. As benchmark in defined as cTnT >5 × 99th percentile ULN,...
Abstract Background Pancreatic adenocarcinoma (PAAD) is a nonimmunogenic tumor, and very little known about the relationship between host immune response patient survival. We aimed to develop an prognostic model (IPM) analyze its relevance tumor profiles of patients with PAAD. Methods investigated differentially expressed genes normal tissues in TCGA PAAD cohort. Immune-related were screened from highly variably weighted gene correlation network analysis (WGCNA) construct IPM. Then,...
Abstract Rationale: Gardner syndrome is a rare autosomal dominant disorder with high degree of penetrance, which characterized by intestinal polyposis, osteomas, and dental abnormalities. Majority patients will develop colorectal cancer the age 40 to 50 years. Mutations in adenomatous polyposis coli gene are supposed be responsible for initiation syndrome. Patient concerns: A 22-year-old Chinese female was admitted our hospital due abdominal pain bloody stool. Diagnosis: The patient...