A5005620494- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Lymphatic System and Diseases
- Thermal Regulation in Medicine
- Phytochemistry and Biological Activities
- Tryptophan and brain disorders
- Mosquito-borne diseases and control
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebrospinal fluid and hydrocephalus
- Cell death mechanisms and regulation
- IL-33, ST2, and ILC Pathways
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Clinical Nutrition and Gastroenterology
- Hormonal Regulation and Hypertension
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant-based Medicinal Research
- Pancreatic function and diabetes
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal motility and disorders
- Advanced Glycation End Products research
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
Southern Medical University
2023-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Wannan Medical College
2024
Wannan Medical College
2024
Wenzhou Medical University
2020-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2023
Nanjing University of Chinese Medicine
2021
Baylor College of Medicine
2013
Chung Shan Medical University Hospital
2005
MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active mutations have recently been reported in lymphoid malignancies, but has not described MDS. To characterize MDS, we sequenced the coding region gene 40 MDS patients. No mutation was detected. We next characterized expression bone marrow CD34+ cells (N = 64). Increased RNA detected 40% Patients with higher had tendency for shorter survival compared to ones lower MYD88, which significant when...
Background and Purpose Pulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure death. Maresin 1 an endogenous lipid mediator known promote inflammation resolution. However, the effect of on PAH remains unclear. Experimental Approach The serum concentration was assessed using UPLC. A mouse model established by combining Sugen 5416 injection hypoxia exposure. After treatment with 1, ventricular systolic pressure (RVSP) function...
ABSTRACT Compound 13b, a newly identified anthraquinone derivative, has demonstrated potent efficacy against the Zika virus. To explore bioavailability and pharmacokinetic properties of compound robust sensitive HPLC‐MS/MS method was established verified to determine its plasma concentration in rats. Sample preparation involved protein precipitation using acetonitrile with testosterone as an internal standard. A Phenomenex Kinetex XB‐C18 column (2.1 × 100 mm, 2.6 μm) utilized for sample...
Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates tissue regeneration 1 (PCTR1) a novel macrophage-derived lipid mediator exhibiting potential anti-inflammatory and pro-resolving benefits. PCTR1 was administrated intraperitoneally with 100 ng/mouse after lipopolysaccharide (LPS) challenged. Survival rate function were used evaluate the protective effects of PCTR1. Lung inflammation response observed...
Abstract Maresin Conjugates in Tissue Regeneration 1 (MCTR1) is a newly identified macrophage‐derived sulfido‐conjugated mediator that stimulates the resolution of inflammation. This study assessed role MCTR1 alveolar fluid clearance (AFC) rat model acute lung injury (ALI) induced by lipopolysaccharide (LPS). Rats were intravenously injected with at dose 200 ng/rat, 8 hours after administration 14 mg/kg LPS. The level AFC was then determined live rats. Primary ATII (Alveolar Type II)...
Abstract Acute respiratory distress syndrome (ARDS) is a lethal clinical characterized by damage of the epithelial barriers and accumulation pulmonary edema fluid. Protectin conjugates in tissue regeneration 1 (PCTR1), an endogenously produced lipid mediator, are believed to exert anti‐inflammatory pro‐resolution effects. PCTR1 (1 µg/kg) was injected at 8 hr after lipopolysaccharide (LPS; 14 mg/kg) administration, rate fluid clearance measured live rats treatment. The primary type II...
The lymphatic vasculature is the natural pathway for resolution of inflammation, yet role pulmonary drainage function in sepsis-induced acute respiratory distress syndrome (ARDS) remains poorly characterized. In this study, indocyanine green-near infrared living imaging was performed to examine septic mouse models. We found that impaired owing damaged structure ARDS. Moreover, prior defects by blocking vascular endothelial growth factor receptor-3 (VEGFR-3) worsened dysfunction and...
Pulmonary fibrosis (PF) is a progressing lethal disease, effective curative therapies remain elusive and mortality remains high. Maresin conjugates in tissue regeneration 1 (MCTR1) DHA-derived lipid mediator promoting inflammation resolution produced macrophage. However, the effect of MCTR1 on PF unknown. We established lung model mice induced by intratracheal administration bleomycin (BLM). On day 7 after establishment, treatment with up to 21. The body weight each mouse was recorded every...
ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health concern. However, there are limited effective treatments available for it. The use of natural products in the management and treatment HCC gaining more attention. Baicalein flavonoid compound that has been reported to have antitumor activities HCC. direct binding targets baicalein still unknown. Therefore, we used DNA‐programmed affinity labeling method identify target validated its function cells. We set blank...
ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by increased permeability of the alveolar-capillary barrier and impaired alveolar fluid clearance. Resolvin E1 (RvE1) specialized pro-resolving mediator derived endogenously from omega-3-polyunsaturated fatty acids. RvE1 (10 μg/kg i.v.) was injected to rats 6 h post-lipopolysaccharide (LPS) (14 mg/kg) induction. After another 3 h, clearance measured in live (n = 8–9). The primary Type II...
Abstract Human pregnane X receptor (PXR) is critical for regulating the expression of key drug‐metabolizing enzymes such as CYP3A and CYP2C. Our recent study revealed that treatment with rodent‐specific PXR agonist pregnenolone‐16α‐carbonitrile (PCN) significantly induced hepatomegaly promoted liver regeneration after two‐thirds partial hepatectomy (PHx) in mice. However, it remains unclear whether activation induces simultaneously promotes metabolic function liver. Here, we investigated...
Abstract Background: Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates tissue regeneration 1 (PCTR1) a novel macrophage-derived lipid mediator exhibiting potential anti-inflammatory and pro-resolving benefits. Methods: PCTR1 was administrated intraperitoneally with 100 ng/mouse after lipopolysaccharide (LPS) challenged. Survival rate function were used evaluate the protective effects of PCTR1. Lung...