A5091954694- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Infant Nutrition and Health
- Preterm Birth and Chorioamnionitis
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Extracellular vesicles in disease
Shandong University
2023-2024
Shandong Provincial Hospital
2023-2024
Shandong First Medical University
2023-2024
Sichuan University
2024
Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported play pivotal roles the development of PE. However, mechanism underlying role maternal exosomes dysfunction regarding PE poorly understood.
Purpose: Over-activation of nuclear factor kappa B (NF-κB) was proven to be involved in the pathogenesis preeclampsia. However, its regulation mechanism is not clear yet. This paper explored role WD repeat domain 5 (WDR5) development late-onset preeclampsia and relationship with NF-κB. Methods: WDR5 expression detected normal placentas from patients. CCK-8 colony formation assays were conducted appraise proliferative ability trophoblast. Migration invasion observed by wound healing transwell...