A5102112139- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Autopsy Techniques and Outcomes
- Nanoparticle-Based Drug Delivery
- Pregnancy and preeclampsia studies
- Medical Coding and Health Information
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Protein Interaction Studies and Fluorescence Analysis
- Immunotherapy and Immune Responses
- Advanced Graph Neural Networks
- HVDC Systems and Fault Protection
- Neurogenesis and neuroplasticity mechanisms
- Nanocluster Synthesis and Applications
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Natural Compound Pharmacology Studies
- Cancer, Lipids, and Metabolism
- Bone health and osteoporosis research
- Extracellular vesicles in disease
- Artificial Intelligence in Healthcare and Education
- Recommender Systems and Techniques
Shandong Academy of Social Sciences
2025
China University of Mining and Technology
2024
Shanghai Jiao Tong University
2014-2023
Shandong Provincial Hospital
2021-2023
Shandong First Medical University
2021-2023
Shandong University
2023
State Key Laboratory of Oncogene and Related Genes
2020-2022
Liaocheng People's Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Peking Union Medical College Hospital
2020-2021
Amyloid-beta (Aβ) accumulation in the brain is believed to play a central role Alzheimer's disease (AD) pathogenesis, and common late-onset form of AD characterized by an overall impairment Aβ clearance. Therefore, development nanomedicine that can facilitate clearance represents promising strategy for intervention. However, previous work this kind was concentrated at molecular level, disease-modifying effectiveness such has not been investigated clinically relevant biological systems. Here,...
Abstract Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. activation cells drives protein internalization via macropinocytosis as a key nutrient-gaining process. By utilizing this unique endocytosis pathway, here we create biologically inspired nanostructure that can induce to ‘drink drugs’ targeting activating transcription factor-5 (ATF5), overexpressed anti-apoptotic factor...
Despite the various mechanisms that involved in pathogenesis of Alzheimer's disease (AD), neuronal damage and synaptic dysfunction are key events leading to cognition impairment. Therefore, neuroprotection neurogenesis would provide essential alternatives rescue AD cognitive function. Here we demonstrated extracellular vesicles secreted from adipose-derived mesenchymal stem cells (ADSCs-derived EVs, abbreviated as EVs) entered brain quickly efficiently following intranasal administration,...
Alzheimer's disease (AD) exerts a heavy health burden for modern society and has complicated pathological background. The accumulation of extracellular β-amyloid (Aβ) is crucial in AD pathogenesis, Aβ-initiated secondary processes could independently lead to neuronal degeneration pathogenesis AD. Thus, the development combination therapeutics that can not only accelerate Aβ clearance but also simultaneously protect neurons or inhibit other subsequent cascade represents promising strategy...
Abstract The failure of immunotherapies in immune-excluded tumor (IET) is largely ascribed to the void intratumoral cytotoxic T cells (CTLs). major obstacles are excessive stroma, defective vasculatures and deficiency signals recruiting CTLs. Here we report a dual-mechanism based CTLs infiltration enhancer, Nano-sapper, which can simultaneously reduce physical microenvironment potentiate immunotherapy IET. Nano-sapper consists core that co-loaded with antifibrotic phosphates-modified...
Amyloid beta (Aβ) and its aggregation forms in the brain have been suggested as key targets for therapy of Alzheimer's disease (AD). Therefore, development nanocarriers that possess both blood–brain barrier permeability Aβ-targeting ability is great importance intervention AD. Here we constructed a biomimetic nanocarrier named apolipoprotein E (ApoE)-reconstituted high density lipoprotein (ANC) from recombinant ApoE synthetic lipids to achieve above goals. α-Mangostin (α-M), polyphenolic...
Abstract Pancreatic cancer is a highly aggressive malignancy that strongly resists extant treatments. The failure of existing therapies majorly attributed to the tough tumor microenvironment (TME) limiting drug access and undruggable targets cells. formation suppressive TME regulated by transforming growth factor beta (TGF‐β) signaling, while poor response short survival almost 90% pancreatic patients results from oncogenic KRAS mutation. Hence, simultaneously targeting both TGF‐β pathways...
Metastasis is the major cause of high mortality in cancer patients; thus, blocking metastatic process critical importance for treatments. The premetastatic niche, a specialized microenvironment with aberrant changes related to inflammation, allows colonization circulating tumor cells (CTCs) and serves as potential target metastasis prevention. However, little effort has been dedicated developing nanomedicine amend niche. Here this study reports niche-targeting micelle modulation...
Widespread adoption of online recruitment platforms has led to explosive growth in employment information, resulting an ever-increasing demand from job seekers for accurate and effective recommendations. Existing studies on the Person-Job Fit models focus correlation between resumes descriptions, with rare consideration given user historical behavior such as click application. On contrary, recommendation methods always ignore crucial information lurking resume text. In addition, continuous...
This study was designed to investigate whether a non-protein nanostructured lipid carrier (NLC) resembling high-density lipoprotein (HDL) could deliver hydrophobic anti-atherogenic drug, lovastatin, foam cells. Lovastatin-loaded NLC (LT-NLC) prepared by nanoprecipitation/solvent diffusion method. The LT-NLC-apoprotein (LT-NLC-apo) incubating LT-NLC with native HDL. physicochemical parameters of were characterized in terms particle size, zeta potential, morphology, entrapment efficiency, and...
Posttraumatic hypothermia prevents cell death and promotes functional outcomes after traumatic brain injury (TBI). However, little is known regarding the effect of on dendrite degeneration spine loss severe TBI. In present study, we used thy1-GFP transgenic mice to investigate dendrites spines in layer V/VI ipsilateral cortex We found that (33 °C) dramatically prevented 1 7 days CCI. The Morris water maze test revealed preserved learning memory functions Hypothermia significantly increased...
Glioma initiating cells (GICs) function as the seed for propagation and relapse of glioma. Designing a smart efficient strategy to target GICs suppress multiple signaling pathways associated with stemness chemoresistance is essential achieving cancer cure. Inspired by metabolic difference in endocytosis between GICs, differentiated glioma cells, normal tailored lipoprotein-like nanostructure developed amplify their internalization into through receptor-stimulated macropinocytosis. As CXCR4...
Bone age (BA) is a crucial indicator for revealing the growth and development of children. This study tested performance fully automated artificial intelligence (AI) system BA assessment Chinese children with abnormal development.A AI based on Greulich Pyle (GP) method was developed by using 8,000 radiographs from five medical centers nationwide in China. Then, total 745 cases (360 boys 385 girls) another tertiary center north China were consecutively collected between January October 2018...
Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta, tau, and α-synuclein aggregates neurodegenerative diseases. However, due to the complex structure ambiguous pathogenic species of proteins, a universal approach remove remains unavailable. Here, we found that polyphenol, α-mangostin, reprogrammed metabolism disease-associated microglia through shifting glycolysis oxidative phosphorylation, which holistically rejuvenated microglial capacity...