A5039622445- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Sperm and Testicular Function
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Reproductive Biology and Fertility
- PARP inhibition in cancer therapy
- Tryptophan and brain disorders
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Cell death mechanisms and regulation
- Metabolism, Diabetes, and Cancer
- Signaling Pathways in Disease
- Neurogenesis and neuroplasticity mechanisms
National Chung Hsing University
2016-2025
Xuzhou Medical College
2024-2025
Zunyi Medical University
2016-2025
Guangdong Academy of Medical Sciences
2025
Guangdong Provincial People's Hospital
2016-2025
Sun Yat-sen University
2017-2024
First Affiliated Hospital of Wenzhou Medical University
2023-2024
Third Affiliated Hospital of Southern Medical University
2019-2024
Wenzhou Medical University
2023-2024
Third Affiliated Hospital of Sun Yat-sen University
2022-2024
The correct identification of pills is very important to ensure the safe administration drugs patients. Here, we use three current mainstream object detection models, namely RetinaNet, Single Shot Multi-Box Detector (SSD), and You Only Look Once v3(YOLO v3), identify compare associated performance.In this paper, introduce basic principles models. We trained each algorithm on a pill image dataset analyzed performance models determine best recognition model. were then used detect difficult...
Abstract Background Defective autophagy is thought to contribute the pathogenesis of many diseases, including cancer. Human plasmacytoma variant translocation 1 (PVT1) an oncogenic long non-coding RNA that has been identified as a prognostic biomarker in pancreatic ductal adenocarcinoma, but how PVT1 operates regulation adenocarcinoma (PDA) unclear. Methods expression level was detected by quantitative real-time polymerase chain reaction (qRT-PCR) and hybridization situ (ISH). Western blot...
Blood-brain barrier (BBB) characteristics are induced and maintained by crosstalk between brain microvascular endothelial cells neighboring cells. Using in vitro cell models, we previously found that a bystander effect was cause for Japanese encephalitis-associated disruption. Brain astrocytes, which neighbor BBB cells, play roles the maintenance of integrity. By extending scope relevant studies, potential mechanism has been shown activation astrocytes could be disruption integrity during...
Abstract Mitochondrial dysfunction, a common cellular hallmark in both familial and sporadic forms of Parkinson's disease (PD), is assumed to play significant role pathologic development progression the disease. Teaghrelin, unique bioactive compound some oolong tea varieties, has been demonstrated protect SH‐SY5Y cells against 1‐methyl‐4‐phenylpyridinium induced neurotoxicity by binding ghrelin receptor activate AMPK/SIRT1/PGC‐1α pathway. In this study, an animal model was established using...
Rapamycin is an immunosuppressant drug used to prevent organ rejection in transplant patients. In this study, we investigated the metabolic effects of rapamycin obese animal model, KK/HlJ mice. Mice were treated with a daily intraperitoneal injection at 2 mg/kg or vehicle for 42 days on high-fat diet. Treated mice lost body weight and adiposity, reduced gain retroperitoneal epididymal fat pads/body weight, decreased serum leptin plasma triglyceride levels had lower liver concentration....
Epigenomic alterations can give rise to various tumor-promoting properties, including therapeutic resistance of cancer cells. Here, we identify an lncRNA, BDNF-AS, whose overexpression is specifically driven by a MEF2A-regulated enhancer in endocrine-resistant and triple-negative breast (TNBC). High levels BDNF-AS tissues not only feature endocrine hormone receptor (HR)-positive patients but also correlate with poor outcomes both HR-positive TNBC patients. Mechanistically, acts as molecular...
Abstract Background: The correct identification of pills is very important to ensure the safe administration drugs patients. We used three currently mainstream object detection models, respectively Faster R-CNN, Single Shot Multi-Box Detector (SSD), and You Only Look Once v3(YOLO v3), identify compare associated performance. Methods: In this paper, we introduce basic principles models. trained each algorithm on a pill image dataset analyzed performance models determine best recognition...
Mammalian sperm capacitation is an essential prerequisite to fertilizion. Although progress had been made in understanding the physiology and biochemistry of capacitation, little known about potential roles epididymal proteins during this process. Here we report that HongrES1, a new member SERPIN (serine proteinase inhibitor) family exclusively expressed rat cauda epididymis up-regulated by androgen, secreted into lumen covers head. Co-culture caudal sperms with HongrES1 antibody vitro...