A5019683141- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Liver Disease and Transplantation
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Adenosine and Purinergic Signaling
- Colorectal Cancer Screening and Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacology and Obesity Treatment
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Horticultural and Viticultural Research
- Colorectal and Anal Carcinomas
- Inflammasome and immune disorders
- Flavonoids in Medical Research
Tungs' Taichung MetroHarbor Hospital
2009-2024
National Chung Hsing University
2021-2024
Abstract Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined understanding role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions from the gut-microbiota, diet, novel endogenous biosynthesis. Investigations included intestinal germ-free study a diet dose response study. Endogenous...
Plumbagin, a natural bicyclic naphthoquinone, has diverse pharmacological properties and biological benefits against number of disorders, including liver disease. Though plumbagin's hepatoprotective potential attracts attention, currently no experimental evidence exists on its effectiveness cholestatic injury. The present study investigated hepatoprotection in the rat model extrahepatic cholestasis using Bile Duct Ligation (BDL). We found that daily plumbagin supplementation protected from...
18β-Glycyrrhetinic acid is a nutraceutical agent with promising hepatoprotective effects. Its protective mechanisms against cholestatic liver injury were further investigated in rodent model of extrahepatic cholestasis caused by Bile Duct Ligation (BDL) rats. The daily oral administration improved histology, serum biochemicals, ductular reaction, oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis. alleviated the BDL-induced hepatic systemic retention bile acids,...
ABSTRACT Bisphenol‐A‐glycidyldimethacrylate (BisGMA) is a frequently used monomer in dental restorative resins. However, BisGMA could leach from resins after polymerization leading to inflammation the peripheral environment. Wogonin, natural flavone derivative, has several benefits, such as antioxidative, anti‐inflammatory and neuroprotective properties. Pretreatment of macrophage RAW264.7 cells with wogonin inhibited cytotoxicity which induced by concentration‐dependent manner. apoptotic...
Magnesium lithospermate B (MLB) is a primary hydrophilic component of Danshen, the dried root Salvia miltiorrhiza used in traditional medicine, and its beneficial effects on obesity-associated metabolic abnormalities were reported our previous study. The present study investigated anti-muscle atrophy potential MLB mice with high-fat diet (HFD)-induced obesity. In addition to abnormalities, HFD had net loss skeletal muscle weight fibers high levels muscle-specific ubiquitin E3 ligases, namely...
Colorectal cancer (CRC) is a prevalent and escalating health issue in Taiwan. This nationwide study delves into the relationship between Human Papillomavirus (HPV) infection CRC risk, employing population datasets from 2007 to 2017. Cox regression analyses revealed statistically significant hazard ratio (HR) of 1.73 (95% CI: 1.63–1.83) for HPV-positive patients, indicating considerably elevated risk compared non-infected individuals. Further, stratification by sex showed males with HPV have...