A5086409527- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Urinary Bladder and Prostate Research
- Acute Ischemic Stroke Management
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Pelvic floor disorders treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Amoebic Infections and Treatments
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Sexual function and dysfunction studies
- Pediatric Urology and Nephrology Studies
- Menstrual Health and Disorders
- Flavonoids in Medical Research
- Heme Oxygenase-1 and Carbon Monoxide
- Ureteral procedures and complications
- Pineapple and bromelain studies
- Immune Response and Inflammation
- Vascular Procedures and Complications
Institute of Nuclear Energy Research
2007-2024
Fu Jen Catholic University
2009-2024
National Institutes of Health
2024
National Defense Medical Center
2024
Johns Hopkins University
2024
China Medical University Hospital
2024
National Institute of Neurological Disorders and Stroke
2024
China Medical University
2024
Tri-Service General Hospital
2024
Johns Hopkins Medicine
2024
Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy. Luteolin an anti-inflammatory flavonoid widely distributed in the plants. Pretreatment luteolin inhibited LPS-induced histological changes of ALI tissue edema. In addition, inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)- α interleukin (IL)-6 production, expression inducible nitric oxide synthase...
Abstract Purpose Oxidative stress and endoplasmic reticulum (ER) may induce renal apoptosis contribute to the pathogenesis of kidney with unilateral ureteral obstruction (UUO). Materials Methods We induced UUO female Wistar rats by ligation left ureter at ureteropelvic junction. The was performed from 4 hr 7 days course. At indicated time, we measured arterial blood pressure flow in each rat, ROS measurement vivo a chemiluminescence analyzer. immunohistochemistry monocyte/macrophage (ED‐1)...
Wogonin is a flavonoid compound which exhibits antioxidation, anti-inflammation, neuroprotection, and antitumorgenesis functions. However, the mechanism of how wogonin reduces proinflammatory cytokine generation in activated microglia unclear. At present, we found inhibited lipopolysaccharide (LPS)-/interferon-γ (INF-γ)-induced interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α). exhibited parallel inhibition on LPS-/INF-γ-induced expression IL-6 TNF-α messenger RNA at same concentration...
This study evaluated a system for local cancer radiotherapy combined with chemotherapy. The delivery is thermosensitive hydrogel containing therapeutic radionuclide (188Re-Tin colloid) and chemotherapeutic drug (liposomal doxorubicin). PCL-PEG-PCL copolymer was designed to spontaneously undergo sol–gel phase transition in response temperature, remaining liquid at room temperature rapidly forming gel body temperature. A scanning electron microscope used observe the microstructure of fully...
ABSTRACT Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins many serious diseases, such as fever, sepsis, multi‐organ failure, meningococcemia, severe morbidities like neurologic disability, or hearing loss. are also called lipopolysaccharide (LPS) important pathogens of acute lung injury (ALI). Rutin has potential beneficial effects anti‐inflammation, antioxidation, anti‐hyperlipidemia, anti‐platelet...
A 17-year-old boy with pyrexia, headache, and frequent drop attacks reported an acute onset of periorbital pain swelling 1 month previously. Coronal computed tomography (CT) identified ethmoid sinusitis, which was treated functional endoscopic sinus surgery intravenous gentamicin, prostaphylline, metronidazone. Because persistent symptoms, the patient returned later. The CT accumulation debris in both frontal sinuses a multilobulated lesion over right lobe. Bicoronal craniotomy performed,...
The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low levels may have association with intracerebral hemorrhage (ICH) severity at admission 3-month outcomes. This study used data obtained from a multi-center registry program in Taiwan. categorized acute spontaneous ICH patients, based on their baseline of total (TC) measured admission, into 3 groups <160, 160-200 >200 mg/dL TC. evaluated risk having initial severity, National Institutes...
Microglia are the major component of intrinsic brain immune system in neuroinflammation. Although wogonin expresses anti‐inflammatory function microglia, little is known about molecular mechanisms protective effect against microglia activation. The aim this study was to evaluate how exerts its BV2 microglial cells after LPS/INFγ administration. Wogonin not only inhibited LPS/ INFγ‐induced PGE2 and NO production without affecting cell viability but also exhibited parallel inhibition on...
Sexual health is defined by the World Health Organization as integration of somatic, emotional, intellectual, and social aspects in ways that are positively enriching will enhance personality, communication, love. The female sexual response multifaceted involves neurovascular, endocrine, psychosocial factors. Optimal comprises physical, mental, emotional aspects, these context which a woman experiences desire, arousal, orgasm. dysfunction females complex highly prevalent disease, commonly...
Bromelain, a cysteine protease found in pineapple, has beneficial effects the treatment of inflammatory diseases; however, its cardiovascular pathophysiology are not fully understood. We investigated effect bromelain on atherosclerosis and regulatory mechanisms hyperlipidemia atheroprone apolipoprotein E-null (
ABSTRACT Bisphenol‐A‐glycidyldimethacrylate (BisGMA) is a frequently used monomer in dental restorative resins. However, BisGMA could leach from resins after polymerization leading to inflammation the peripheral environment. Wogonin, natural flavone derivative, has several benefits, such as antioxidative, anti‐inflammatory and neuroprotective properties. Pretreatment of macrophage RAW264.7 cells with wogonin inhibited cytotoxicity which induced by concentration‐dependent manner. apoptotic...
We hypothesize that increased H(2)O(2) in the urinary bladder may affect ATP and acetylcholine release activate urothelial purinergic muscarinic signaling consequently leading to hyperactive bladder.We infused 0.3% 1.5% evaluate voiding function frequency, pelvic afferent (PANA) efferent nerve activity (PENA) simultaneously urethane anesthetized rats. measured content rat under saline or stimulation. Hyaluronic acid, muscarinic, receptor antagonists were used their effects mechanisms on...
No study has investigated the role of pancreatic cancer in stroke risk using population data. We used claims data obtained from a universal health insurance program Taiwan to evaluate patients. From catastrophic disease registry insurance, we identified 7479 patients with malignancy without history 2000 2009. The comparison cohort consisted 29,916 individuals 1 million insured people and history, matching by propensity score. followed each selected individual until was diagnosed or being...
The awareness on ischemic heart disease (IHD) in women with dysmenorrhea is insufficient. We utilized the National Health Insurance Research Database (NHIRD) of Taiwan to evaluate this relationship. From claims data, we established a cohort aged 15-50 years primary diagnosed from 2000 2008 (n = 18,455) and comparison 36,910) without dysmenorrhea, frequency matched by age diagnosis date. Both cohorts were followed until end 2013 assess IHD events. With 75% study population 15-29 years,...
Multimorbidity is common in patients who experience stroke. Less known about the effect of specific multimorbidity patterns on long-term disability with Furthermore, given increased poststroke frequently seen female vs male patients, it unknown whether has a similar association both sexes. We assessed clusters were associated greater burden overall and by sex.
This study explores the potential efficacy of chlorogenic acid (CGA) in mitigating lipopolysaccharide (LPS)-induced cystitis a mice model. C57BL/6J were divided into four groups: normal control (NC), LPS, LPS + low CGA, and high CGA. Evaluation methods included cystometrogram (CMG), histopathological, western blot, immunohistological analysis. In group, CMG revealed abnormal voiding behavior with increased micturition pressure, voided volume (VV), decreased frequency. Low CGA treatment...