A5084447476- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- ECG Monitoring and Analysis
- Systemic Lupus Erythematosus Research
- Ultrasound and Hyperthermia Applications
- Gene expression and cancer classification
- Genetic Associations and Epidemiology
- Diagnosis and Treatment of Venous Diseases
- Autophagy in Disease and Therapy
- Machine Learning in Bioinformatics
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Drug-Induced Ocular Toxicity
- Cardiac Health and Mental Health
- Cardiovascular Health and Risk Factors
Children's Hospital of Philadelphia
2024
Chung Shan Medical University
2014-2024
Chung Shan Medical University Hospital
2014-2024
Philadelphia University
2019-2021
Genomics Research Center, Academia Sinica
2014-2017
Fifth Affiliated Hospital of Zhengzhou University
2014-2016
Biodiversity Research Center, Academia Sinica
2013
National Yang Ming Chiao Tung University
2012
National Taipei University of Technology
2011
Coronary artery disease (CAD) covers a wide spectrum from persons who are asymptomatic to those presenting with acute coronary syndromes (ACS) and sudden cardiac death. atherosclerotic is chronic, progressive process that leads plaque development progression within the epicardial arteries. Being dynamic process, CAD generally presents prolonged stable phase, which may then suddenly become unstable lead an event. Thus, concept of "stable CAD" be misleading, as risk for events continues exist,...
Acute lung injury (ALI) is a life-threatening disease that characterised by the rapid onset of inflammatory responses. Lipopolysaccharide (LPS) an endotoxin plays important role in triggering ALI via pneumonia and sepsis. However, no effective therapeutic strategies are currently available to treat ALI. Nerolidol aliphatic sesquiterpene alcohol found essential oils many flowers as well floral plants. It has been shown exhibit anti-inflammatory, antioxidant, anticancer properties. Herein, we...
As photoplethysmographic (PPG) signals are comprised of numerous pieces important physiological information, they have been widely employed to measure many parameters. However, only a high-quality PPG signal can provide reliable assessment. Unfortunately, easily corrupted by motion artifacts and baseline drift during recording. Although several rule-based algorithms developed for evaluating the quality signals, few artificial intelligence-based presented. Thus, this study aims classify using...
In the last decade, cuffless blood pressure measurement technology has been widely studied because it could be applied to a wearable apparatus. Electrocardiography (ECG), photo-plethysmography (PPG), and phonocardiography are always used detect pulse transit time (PTT) changed tendencies of PTT have negative relationship. this study, PPG signal was replaced by impedance plethysmography (IPG) PTT. The placement direction electrode array for IPG were discussed. Then, we designed an ring that...
Genotoxic stress from environmental pollutants plays a critical role in cytotoxicity. The most abundant nitro-polycyclic aromatic hydrocarbon pollutants, 1-nitropyrene (1-NP), is generated during fossil fuel, diesel, and biomass combustion under sunlight. Macrophages, the key regulators of innate immune system, provide first line defense against pathogens. toxic effects 1-NP on macrophages remain unclear. Through lactate dehydrogenase assay, we measured cytotoxicity induced by 1-NP. Our...
ABSTRACT Gallstone disease is a highly prevalent and costly gastrointestinal disease. Yet, genetic variation in susceptibility to gallstone its implication metabolic regulatory pathways remain be explored. We report trans-ancestry genome-wide association meta-analysis of including 88,063 cases 1,490,087 controls the UK Biobank, FinnGen, Biobank Japan, Million Veteran Program. identified 91 (37 novel) risk loci across found replication statistically compelling signals All Us Research A...
Cigarette smoking is a well-established risk factor for various diseases, such as cardiovascular neurodegeneration, and cancer. Cadmium nitrate (Cd(NO3)2) one of the major products from cigarette smoke. Up to now, no supporting evidence on Cd(NO3)2-induced apoptosis its related working mechanism in neurons has been found. In present study, mode cell death, caspase activities, reactive oxygen species (ROS) generation, mitochondrial dysfunction N2a cells, which are neuron-like were assessed by...
Photoplethysmography (PPG) has been extensively employed to acquire some physiological parameters such as heart rate, oxygen saturation, and blood pressure. However, PPG signals are frequently corrupted by motion artifacts baseline wandering, especially for the reflective sensor. Several different algorithms have studied determining signal quality of characteristic its waveform rule-based methods. The levels usually were defined manual operations. Thus, whether good waveforms enough increase...
Abstract 3-Bromofluoranthene (3-BrFlu) is the secondary metabolite of fluoranthene, which classified as a polycyclic aromatic hydrocarbon, through bromination and exists in fine particulate matter air pollutants. Endothelial dysfunction plays critical role pathogenesis cardiovascular vascular diseases. Little known about molecular mechanism 3-BrFlu on endothelial vivo vitro assay. In present study, included concentration-dependent changes ectopic angiogenesis sub-intestinal vein dilation...
Atherosclerotic cardiovascular disease (ASCVD) is one of the leading causes death worldwide and in Taiwan. It highly prevalent has a tremendous impact on global health. Therefore, Taiwan Society Cardiology developed these best-evidence preventive guidelines for decision-making clinical practice involving aspects primordial prevention including national policies, promotion health education, primary risk factors, management control factors. These cover full spectrum ASCVD, chronic coronary...
1-Nitropyrene (1-NP), one of the most abundant nitropolycyclic aromatic hydrocarbons (nitro-PAHs), is generated from incomplete combustion carbonaceous organic compounds. 1-NP a specific marker diesel exhaust and an environmental pollutant probable carcinogen. Macrophages participate in immune defense against invasive pathogens heart, lung, kidney infection diseases. However, no evidence has indicated that induces apoptosis macrophages. In present study, was found to induce...
Electronic health (eHealth) is a strategy to improve the physical and mental condition of human, collecting daily physiological data information from digital apparatuses. Body weight blood pressure (BP) are most popular important data. The goal this study develop minimal contact BP measurement method based on commercial body weight-fat scale, capturing biometrics when users stand it. pulse transit time (PTT) extracted ballistocardiogram (BCG) impedance plethysmogram (IPG), measured by four...
Acute lung injury (ALI) is a severe syndrome, and there are no effective therapeutic appropriate medicines. Nerolidol, which exists in the essential oils of aromatic plants flowers, exhibits antioxidative anti-inflammatory activities. The present study evaluated potential protective effect nerolidol ALI related mechanism lipopolysaccharide (LPS)-treated mice. Here, inhibited LPS-induced neutrophil other leukocyte infiltration alveolar space. LPS increased cytokines, chemokines, adhesion...
Despite minoxidil and finasteride already being approved by the Food Drug Administration (FDA) for treatment of hair loss, it is important to identify new innovative treatments such as looking a solution in Chinese herbal medicine. One consider BeauTop (BT), whose primary ingredients include Panax japonicus (T.Nees), C.A. Mey. (Araliaceae), Astragalus membranaceus (Fisch) Bunge (Fabaceae), Angelica sinensis (Oliv.) Diels (Apiaceae), Ligustrum lucidum W.T. Aiton (Oleaceae), Rehmannia...
Deep vein thrombosis (DVT) of lower limbs can easily arise from prolonged sitting or standing. Elders and pregnant women are most likely to have this disease. When the embolus DVT comes pass lung, it will become a life-threatening Thus, for disease, early detection treatment needed. The goal study was develop an examination system be used at non-medical places detect with light reflection rheography (LRR). Consisting wearable device mobile application (APP), is operated in wireless manner...
For the primary prevention of atherosclerotic cardiovascular disease (ASCVD), recommended treatment target for each modifiable risk factor is as follows: reducing body weight by 5-10%; blood pressure < 130/80 mmHg (systolic 120 in high-risk individuals); low-density lipoprotein cholesterol (LDL-C) 100 mg/dL individuals, LDL-C 115 moderate-risk 130 low-risk and 160 those with a minimal; complete persistent abstinence from cigarette smoking; hemoglobin A1C 7.0%; fulfilling amounts six food...
Identification of amino acid propensities that are strong determinants linear B-cell epitope is very important to enrich our knowledge about epitopes. This can also help obtain better prediction. Typical prediction methods combine various in different ways improve accuracies. However, fewer but features may yield Moreover, for a propensity, when the sequence length k, there will be k values, which should treated as single unit feature selection and hence usual method not work. Here we use...
Acute lung injury (ALI) is a clinical syndrome with high morbidity and mortality rates mainly caused by Gram-negative bacteria. Nevertheless, an effective treatment strategy for ALI yet to be developed. Zerumbone, sesquiterpene isolated from Zingiber zerumbet Smith, possesses several advantageous bioeffects such as antioxidation, anti-inflammation, antiulcer. Pretreatment of zerumbone inhibited lipopolysaccharide (LPS)-induced arterial blood gas exchange, neutrophils infiltration, increased...
Hydroxychloroquine is widely used to treat certain viral and rheumatic diseases including systemic lupus erythematosus. Cardiac arrhythmia an important safety issue with hydroxychloroquine. The aim of this study was investigate whether hydroxychloroquine increases new-onset among patients erythematosus.This a nested case-control using data from the Longitudinal Health Insurance Database Taiwan. A conditional logistic regression model analyse differences in risk between erythematosus without...