A5101542559- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Myocardial Infarction Research
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Fibrosis and Remodeling
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Lung Cancer Treatments and Mutations
- Tissue Engineering and Regenerative Medicine
National Cheng Kung University Hospital
2016-2025
Jiangxi Mental Health Center
2024
Nanchang University
2024
Northwest A&F University
2024
Kaohsiung Medical University
2014-2022
Kaohsiung Municipal Ta-Tung Hospital
2022
Northwest University
2022
Fudan University
2022
National Cheng Kung University
2000-2020
Institute of Botany
2019
Coronary artery disease (CAD) covers a wide spectrum from persons who are asymptomatic to those presenting with acute coronary syndromes (ACS) and sudden cardiac death. atherosclerotic is chronic, progressive process that leads plaque development progression within the epicardial arteries. Being dynamic process, CAD generally presents prolonged stable phase, which may then suddenly become unstable lead an event. Thus, concept of "stable CAD" be misleading, as risk for events continues exist,...
Importance In addition to protective effects on the cardiovascular system, statins may reduce risk of breast cancer recurrence owing potential anti-inflammatory benefits. Given that patients with in Asia are relatively younger at diagnosis and most free from traditional factors, it is uncertain whether use can improve survival. Objective To investigate association statin cancer- noncancer-associated survival cancer. Design, Setting Participants This cohort study used Taiwanese National...
Given the rapidly growing burden of cardiovascular disease (CVD) in Asia, this study forecasts CVD and associated risk factors Asia from 2025 to 2050.
The American Heart Association Get With the Guidelines (GWTG) program has improved care quality of acute myocardial infarction (AMI) with important implications for other countries in world. This study evaluated incidence and AMI Taiwan assessed compliance GWTG Taiwan.We used National Health Insurance Research Database (1999-2008) to identify hospitalized patients ≥18 years age presenting AMI. temporal trends annual were evaluated. age-adjusted (/100 000 person-years) increased from 28.0...
In Taiwan, the incidence of non-ST segment elevation acute coronary syndrome (NSTE-ACS) continues to increase in recent years. The purpose this guideline is help health care professionals Taiwan use adequate tests and treatments for management NSTE-ACS. For rapid diagnosis, addition history physical examination, 0/3 h diagnosis protocol with high sensitivity cardiac troponin assay recommended guideline. Dual antiplatelet anticoagulation therapies are important parts initial treatment. Risk...
In patients with diabetes mellitus (DM), incident cardiovascular (CV) events are associated poor long-term outcomes. Serum high-sensitivity troponin I (hs-TnI) is widely used to diagnose and predict outcomes in acute coronary syndrome, however, few studies have investigated the accuracy of urine hs-TnI as a predictor for CV DM. The enrolled participants included Fresh levels were measured. Medical records determine number prospectively 3 months. study cohort comprised 378 participants. We...
Dual antiplatelet therapy (DAPT) is the standard treatment for acute myocardial infarction (MI). This study aimed to investigate use of DAPT and de-escalation after discharge in real-world practice among patients with MI undergoing percutaneous coronary intervention (PCI) Taiwan. Using Taiwan National Health Insurance Research Database, we included who received PCI survived from 2011 2021. The choice different P2Y12 inhibitors at were analyzed. Overall, 58989 (mean age 61.9 ± 13.2 years,...
Objectives: IMP7068 is a potent and selective inhibitor of WEE1 kinase. Following oral administration predominantly metabolized by CYP3A4 in the liver. The major metabolite, IMP7253, also pharmacologically active. Population pharmacokinetic (PK) modeling was conducted to characterize concentration-time profiles IMP7253 patients with advanced solid tumors.Methods: population PK analysis based on data from Phase 1 dose-escalation study (IMP7068-101). dataset contains 1006 1028 quantifiable...
Abstract Objective Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a standard therapy for patients who respond poorly to or cannot tolerate statins. However, identifying responders PCSK9 remains unclear. This study investigates the characteristics of achieve target LDL-C reduction (< 70 mg/dl) after inhibitor therapy. Methods A multicenter, retrospective cohort included initiating at 11 teaching hospitals in Taiwan (2017–2021). Baseline characteristics, lipid-lowering...
Elevated circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Early control LDL-C to prevent ASCVD later in life important. The Taiwan Society Lipids and Atherosclerosis association with the other seven societies developed this new lipid guideline focusing on subjects without clinically significant ASCVD. In for primary prevention, recommended target based stratification. A healthy lifestyle recommendations foods,...
Background Epidemiological and clinical studies have clearly established the link between low-density lipoprotein cholesterol (LDL-C) atherosclerosis-related cardiovascular consequences. Although it has been a common practice for physicians to prescribe lipid-lowering therapy patients with dyslipidemia, achievement rate is still not satisfied in Taiwan. Therefore, determinants achieving LDL-C target needed be clarified better healthcare of dyslipidemia. Method This registry-type prospective...
In the Asia-Pacific region, heart failure (HF) is associated with significant health and socioeconomic burden. Given differences in epidemiology of HF, as well availability healthcare resources between Asian Western countries, an Pacific Society Cardiology (APSC) working group developed consensus recommendations on management chronic HF region. The APSC expert panel reviewed appraised available evidence using Grading Recommendations Assessment, Development Evaluation (GRADE) system....
Importance Tyrosine kinase inhibitors (TKIs) have been recognized as the standard treatment for patients with non–small cell lung cancers (NSCLCs) and epidermal growth factor receptor (EGFR) sequence variation. Although TKIs reported to cause cardiotoxicity, they are widely administered owing high prevalence of EGFR variation in Taiwan. Objective To compare outcomes death major adverse cardiac cerebrovascular events among NSCLC who use do not a national cohort. Design, Setting, Participants...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, inflammation, and oxidative stress. This study investigated the association of plasma PCSK9 levels with presence severity peripheral artery disease (PAD) parameters endothelial homeostasis.A post hoc analysis 2 randomized trials (115 patients, 44 PAD 71 without atherosclerotic disease) was conducted. Patients had significantly higher than those (471.6±29.6 versus 302.4±16.1 ng/mL, P<0.001)....
The prevalence of heart failure is increasing, causing a tremendous burden on health care systems around the world. Although mortality rate has been significantly reduced by several effective agents in past 3 decades, yet it remains high observational studies. More recently, new classes drugs emerged with significant efficacy reducing and hospitalization chronic ejection fraction (HFrEF) preserved (HFpEF). To integrate these therapies prioritize them management Asian patients, Taiwan Society...
The previously published 2017 Taiwan Lipid Guidelines for High Risk Patients becomes the standard guidance of dyslipidemia management patients with atherosclerotic cardiovascular disease (ASCVD) in Taiwan. New clinical trials lipid lowering therapy were successively after 2017. study results changed treatment concept ASCVD. Therefore, an update focusing on strategy ASCVD necessary. In this focused guideline, targets low-density lipoprotein cholesterol (LDL-C) modified. algorithm LDL-C was...