A5085274967- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Mechanical Circulatory Support Devices
- MicroRNA in disease regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Failure Treatment and Management
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Nutrition and Health in Aging
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Ultrasound and Hyperthermia Applications
- Alzheimer's disease research and treatments
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical Economics and Policy
- Cardiac Ischemia and Reperfusion
- Photoacoustic and Ultrasonic Imaging
- Signaling Pathways in Disease
- Telomeres, Telomerase, and Senescence
Mackay Memorial Hospital
2017-2025
Mackay Medical College
2017-2025
Taipei Medical University
2019-2022
Academia Sinica
1995-2022
Taipei Medical University-Shuang Ho Hospital
2016
Research Center for Environmental Changes, Academia Sinica
2015
Mennonite Christian Hospital
2010
Obesity, a known risk factor for cardiovascular disease and heart failure (HF), is associated with adverse cardiac remodeling in the general population. Little about how nutritional status modifies relationship between obesity outcomes. We aimed to investigate association of clinical characteristics, echocardiographic changes, outcomes community.We examined 5,300 consecutive asymptomatic Asian participants who were prospectively recruited health screening program (mean age 49.6 ± 11.4 years,...
This study aimed to evaluate the prognostic significance of nutritional status in post-discharge Asians with heart failure preserved ejection fraction (HFpEF).We examined implications body mass index (BMI) and markers among consecutive patients hospitalized for HFpEF. Nutritional metrics were estimated by serum albumin (SA), (PNI), Controlling Status (CONUT) score, geriatric risk index. Among 1120 (mean age: 77.2 ± 12.6 years, 39.4% men), mean SA levels, PNI, CONUT scores, 3.3 0.6 g/dL, 40.2...
The chemokines CXCL9 and CCL20 have been reported to be associated with ventricular dysfunction. This study was aimed investigate the effects of CXCL9/CCL20 on cardiac fibrosis following myocardial infarction (MI). Blood samples patients MI were obtained determine serum CXCL9, CCL20, tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β). expression in hypoxia-incubated H9c2 cells TNF-α/TGF-β-activated peripheral blood mononuclear (PBMCs) examined. experimental rats produced...
BACKGROUND Obesity, a known risk factor for cardiovascular disease and heart failure (HF), is associated with adverse cardiac remodeling in the general population. Little about how nutritional status modifies relationship between obesity outcomes. We aimed to investigate association of clinical characteristics, echocardiographic changes, outcomes community. METHODS AND FINDINGS examined 5,300 consecutive asymptomatic Asian participants who were prospectively recruited health screening...
Background: Fluorescent gold nanoclusters conjugated with α-lipoic acid (FANCs) have shown great promise for drug development. In a previous study, FANCs did not show any acute or subacute toxicity under 0.6–20 μM/100 μL/25 g body weight in male and female ICR mice. However, the chronic of has been studied. Aim study: This study used oral administration to determine long-term safety profile adverse effects Methods: vivo was examined via The daily food consumption, weight, hematological...
Abstract Objective Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a standard therapy for patients who respond poorly to or cannot tolerate statins. However, identifying responders PCSK9 remains unclear. This study investigates the characteristics of achieve target LDL-C reduction (< 70 mg/dl) after inhibitor therapy. Methods A multicenter, retrospective cohort included initiating at 11 teaching hospitals in Taiwan (2017–2021). Baseline characteristics, lipid-lowering...
Elevated circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Early control LDL-C to prevent ASCVD later in life important. The Taiwan Society Lipids and Atherosclerosis association with the other seven societies developed this new lipid guideline focusing on subjects without clinically significant ASCVD. In for primary prevention, recommended target based stratification. A healthy lifestyle recommendations foods,...
We explored the roles of hsa-microRNA (miR)-409-3p in senescence and signalling mechanism human endothelial progenitor cells (EPCs). Hsa-miR-409-3p was found upregulated senescent EPCs. Overexpression miRNA mimics young EPCs inhibited angiogenesis. In EPCs, compared to protein phosphatase 2A (PP2A) downregulated, with activation p38/JNK by phosphorylation. Young treated siPP2A caused angiogenesis p38/JNK, similar findings Time series analysis showed, hsa-miR-409-3p mimics, PP2A steadily...
Current data on post-discharge mortality and rehospitalization is still insufficient among in-hospital survivors of cardiogenic shock (CS), including acute myocardial infarction (AMI) non-AMI survivors. Patients with CS who survived after hospital discharge were selected from the Taiwan National Health Insurance Research Database. Each patient was followed up at 3-year intervals. Mortality analyzed using Kaplan-Meier curves Cox regression models. There 16,582 eligible patients. Of these,...
Abstract This research explores the role of microRNA in senescence human endothelial progenitor cells (EPCs) induced by replication. Hsa‐miR‐134‐5p was found up‐regulated senescent EPCs where overexpression improved angiogenic activity. Hsa‐miR‐134‐5p, which targeted transforming growth factor β‐activated kinase 1‐binding protein 1 (TAB1) gene, down‐regulated TAB1 protein, and inhibited phosphorylation p38 mitogen‐activated (p38) hsa‐miR‐134‐5p‐overexpressed EPCs. Treatment with siRNA...
Atherosclerosis caused major morbidity and mortality worldwide. Molecules possessing lipid-lowering and/or anti-inflammatory properties are potential druggable targets against atherosclerosis. We examined the anti-atherosclerotic effects of fluorescent gold nanoclusters (FANC), which were dihydrolipoic acid (DHLA)-capped 2-nm nanoparticles. evaluated 8-week FANC in Western-type diet-fed ApoE-deficient mice by either continuous intraperitoneal delivery (20 μM, 50 μl weekly) or via drinking...
Abstract The therapeutic effects of ultrasonic microbubble transfection (UMT)-based vascular endothelial growth factor 165 (VEGF165) gene delivery on young and senescent progenitor cells (EPCs) were investigated. By UMT, plasmid DNA (pDNA) can be delivered into both EPCs EPCs. In the UMT groups, higher pDNA-derived protein expression was found in than Consistent with this finding, a intracellular level pDNA copy number detected EPCs, peak at 2-h time point post UMT. Ultrasonic or without...
This study investigated temporal trends in the treatment and mortality of patients with cardiogenic shock (CS) Taiwan relation to acute myocardial infarction (AMI) accreditation implemented 2009 unavailability percutaneous ventricular assist devices.Data diagnosed as having CS between January 2003 December 2017 were collected from Taiwan's National Health Insurance Research Database. Each case was followed date emergency department arrival or hospital admission for first incident associated...
Background Fragmented QRS (fQRS) morphology as a surrogate marker of the possible presence myocardial scarring has been shown to confer higher risk in patients with reduced ejection fraction heart failure. We aimed investigate pathophysiological correlates and prognostic implications fQRS failure preserved (HFpEF). Methods Results consecutively studied 960 HFpEF (76.4±12.7 years, men: 37.2%). was assessed using body surface ECG during hospitalization. available classified into 3 categories...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor is a powerful low density lipoprotein cholesterol (LDL-C)-lowering therapy, but this drug expensive. This study aimed to describe the real-world treatment conditions in patients initiating PCSK9 Taiwan.
Even though the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, alirocumab and evolocumab, have been approved to reduce plasma low-density lipoprotein cholesterol (LDL-C) risk of atherosclerotic cardiovascular disease in high-risk patients, real-world data showing comparisons lipid-lowering effects between evolocumab are scarce because low prescription rates PCSK9 inhibitors clinical practice.Between Feb 2018 Sep 2021, 22 patients who received at a tertiary medical center...
Patients with high bleeding risk (HBR) may exhibit uncertain adherence to dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation. The current population-based cohort study aimed investigate the sex-based differences in adverse outcomes among HBR population by analyzing National Health Insurance Research Database Taiwan.
Abstract This study explores the impact of senescence on autocrine C‐C motif chemokine ligand 5 (CCL5) in human endothelial progenitor cell (EPCs), addressing poorly understood decline number and function EPCs during ageing. We examined effects replication‐induced CCL5/CCL5 receptor (CCR5) signalling angiogenic activity vitro vivo. also explored microRNAs controlling CCL5 secretion senescent EPCs, its EPC activity, validated our findings humans. CCR5 levels were reduced, leading to...