A5089948893- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Advanced X-ray and CT Imaging
- Vascular Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Genomics, phytochemicals, and oxidative stress
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Vascular anomalies and interventions
- Pharmaceutical Economics and Policy
- Kawasaki Disease and Coronary Complications
- Pharmaceutical industry and healthcare
- Cardiovascular Function and Risk Factors
- Glutathione Transferases and Polymorphisms
- Robotic Locomotion and Control
- Testicular diseases and treatments
Changhua Christian Hospital
2016-2025
National Chung Hsing University
2023-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2022
Far Eastern Memorial Hospital
2022
Chung Shan Medical University Hospital
2022
Chienkuo Technology University
2013-2018
National Taiwan University
2015
Chung Shan Medical University
2000
University of Manchester
1999
Abstract Objective Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a standard therapy for patients who respond poorly to or cannot tolerate statins. However, identifying responders PCSK9 remains unclear. This study investigates the characteristics of achieve target LDL-C reduction (< 70 mg/dl) after inhibitor therapy. Methods A multicenter, retrospective cohort included initiating at 11 teaching hospitals in Taiwan (2017–2021). Baseline characteristics, lipid-lowering...
Background and objective: COPD patients with community-acquired pneumonia (CAP) have worse clinical outcomes, as compared to those without COPD. Cardiovascular disease (CVD) is a common comorbidity for patients. Whether comorbid CVD will increase the risk of CAP not well investigated. The incidence factors associated in were analyzed. Methods: medical records newly diagnosed between 2007 2010 reviewed. patients' characteristics, history CVD, occurrence CAP, type medication recorded....
Rosmarinic acid (RA) is a phenolic compound that has several bioactivities, such as anti-inflammatory and antioxidant activities. Here, we further investigate the effect of RA on rat A7r5 aortic smooth muscle cells with exposure to lipopolysaccharide (LPS). Our findings showed low-dose (10-25 μM) did not influence cell viability morphology significantly inhibited LPS-induced mRNA expression pro-inflammatory mediators TNFα, IL-8, inducible NO synthase (iNOS). Consistently, reduced production...
Shared decision-making (SDM) promotes patient awareness about medical conditions and treatments, facilitating involvement in care decisions. This two-stage multicenter study evaluated impacts of SDM Taiwanese adults with atrial fibrillation (AF) eligible for novel oral anticoagulant (NOAC) therapy. Participants were NOAC-naïve (part I) or dabigatran-experienced II). During Stage I, part I participants (n = 124) completed a semi-structured survey (understanding evaluation sections only)...
We report on a sensor data fusion algorithm via an extended Kalman filter for estimating the spatial motion of bipedal robot. Through fusing sensory information from joint encoders, 6-axis inertial measurement unit and 2-axis inclinometer, robot's body state at specific fixed position can be yielded. This is also equal to CoM when robot in standing posture suggested by detailed CAD model In addition, this further utilized provide feedback control with walking gait. The overall strategy...
P2Y12 inhibitor monotherapy is an alternative antiplatelet strategy in patients undergoing percutaneous coronary intervention (PCI). However, the ideal for unclear.We performed a multicenter, retrospective, observational study to compare efficacy and safety of with clopidogrel versus ticagrelor acute syndrome (ACS) PCI. From 1 January 2014 31 December 2018, 610 ACS who received either (n = 369) or 241) after aspirin was discontinued prematurely were included. Inverse probability treatment...
Ageing is one of the major risk factors human diseases, including cancer, diabetes, and cardiovascular disease. Mulberry exhibits a wide range functions, such as anti-oxidant, anti-inflammation, anti-diabetes. In this study, we investigated role mulberry polyphenol extract (MPE) in K-Ras-induced senescence smooth muscle cells. Forced expression K-Ras enhanced A7r5 cells shown by elevation β-galactosidase activity. Treatment with MPE significantly repressed Ras, phosphorylated ERK, level....
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor is a powerful low density lipoprotein cholesterol (LDL-C)-lowering therapy, but this drug expensive. This study aimed to describe the real-world treatment conditions in patients initiating PCSK9 Taiwan.
Little information is available in Asia about the real-world practice of dual antiplatelet therapy (DAPT) duration for acute coronary syndrome (ACS) and its influence on clinical outcomes.
Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present VTE without exhibiting the traditional risk factors. We investigated relationship history of using National Health Insurance Research Database (NHIRD).We conducted retrospective, nationwide, population-based case-control study NHIRD. identified 2,282 patients diagnosed 392,635 subjects from 2000 to 2013. After development an age index...
Background Heart failure is a frequent complication of type 2 diabetes mellitus (T2DM). Plasma cholesterol, particularly the proatherogenic low-density lipoprotein (LDL) impairs heart function by promoting atheroma formation and ventricular dysfunction. Considering established effect cholesterol on cardiovascular system, we hypothesized that plasma LDL may influence left in individuals with T2DM. Methods This cross-sectional study was conducted at tertiary care hospital Taiwan. Enrollment...
Transient global amnesia (TGA) could be encountered in many situations even during invasive procedures. In ablation therapy for arrhythmia, there was only one reported case the of premature ventricular beats. We report a 31-year-old man having paroxysmal supraventricular tachycardia who underwent TGA at end and recovered quickly after 8-9 hours later. Long-term follow-up showed no neurologic deficits 8 months.
Extra-proliferation and increased migration of vascular smooth cells con-tribute to the formation atherosclerosis. Ras small G proteins play a critical role in prolif-eration wide range cells. Mulberry, an economic fruit Asia, exhibits anti-inflammation, anti-migration, anti-oxidant properties. The mechanisms action mulberry extracts on K-Ras protein-induced proliferation muscle cell have not been extensively investigated. In this study, we explored effects polyphenol (MPE)...