A5023926770- Fluid Dynamics and Thin Films
- Nonlinear Dynamics and Pattern Formation
- Liquid Crystal Research Advancements
- Model Reduction and Neural Networks
- Surface Modification and Superhydrophobicity
- Numerical methods in engineering
- Fluid Dynamics and Heat Transfer
- Lattice Boltzmann Simulation Studies
- Power Transformer Diagnostics and Insulation
- Solidification and crystal growth phenomena
- Advanced Numerical Methods in Computational Mathematics
- Advancements in Semiconductor Devices and Circuit Design
- Rheology and Fluid Dynamics Studies
- Cancer therapeutics and mechanisms
- Metalloenzymes and iron-sulfur proteins
- Hemodynamic Monitoring and Therapy
- Semiconductor materials and devices
- Silicon Carbide Semiconductor Technologies
- Metal-Catalyzed Oxygenation Mechanisms
- Polyamine Metabolism and Applications
- Nonlinear Photonic Systems
- Micro and Nano Robotics
- Adhesion, Friction, and Surface Interactions
- Molecular Communication and Nanonetworks
- Block Copolymer Self-Assembly
National Yang Ming Chiao Tung University
1989-2024
National Taiwan University
2010-2024
National Center for Theoretical Sciences
2022-2023
National Taiwan University of Science and Technology
2023
National Chung Hsing University
2010-2015
Loughborough University
2013-2014
New Jersey Institute of Technology
2010-2012
National Pingtung University
2010
National Taipei University
2010
United Microelectronics (Taiwan)
2009
Type II topoisomerases (TOP2s) resolve the topological problems of DNA by transiently cleaving both strands a duplex to form cleavage complex through which another segment can be transported. Several widely prescribed anticancer drugs increase population TOP2 complex, leads TOP2-mediated chromosome breakage and death cancer cells. We present crystal structure large fragment human TOP2β complexed drug etoposide reveal structural details drug-induced stabilization complex. The interplay...
Significance Polyamines are small organic compounds that carry multiple positive charges at physiological pH. With a high capacity to interact with the acidic surface patches of proteins and nucleic acids, polyamines may regulate variety cellular processes, fluctuations in intracellular polyamine levels rigorously controlled during cell growth differentiation through interplay between enzyme ornithine decarboxylase (ODC) two regulatory proteins: antizyme (Az) inhibitor (AzIN). ODC initiates...
Mechanisms of enzymatic epoxidation via oxygen atom transfer (OAT) to an olefin moiety is mainly derived from the studies on thiolate-heme containing epoxidases, such as cytochrome P450 epoxidases. The molecular basis catalyzed by nonheme-iron enzymes much less explored. Herein, we present a detailed study nonheme iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase, AsqJ. native substrate analogues with different para substituents ranging electron-donating groups (e.g., methoxy)...
Abstract AsqJ, an iron(II)‐ and 2‐oxoglutarate‐dependent enzyme found in viridicatin‐type alkaloid biosynthetic pathways, catalyzes sequential desaturation epoxidation to produce cyclopenins. Crystal structures of AsqJ bound cyclopeptin its C3 epimer are reported. Meanwhile, a detailed mechanistic study was carried out decipher the mechanism. These findings suggest that pathway involving hydrogen atom abstraction at C10 position substrate by short‐lived Fe IV ‐oxo species subsequent...
We consider free surface instabilities of films flowing on inverted substrates within the framework lubrication approximation. allow for presence fronts and related contact lines, explore role which they play in instability development. It is found that a line, modeled by commonly used precursor film model, leads to without any additional natural or excited perturbations. A single parameter D=(3Ca)^{1/3}\cot\alpha$, where $Ca$ capillary number $\alpha$ inclination angle, identified as...
We study contact line induced instabilities for a thin film of fluid under destabilizing gravitational force in three dimensional setting. In the previous work (Phys. Fluids, {\bf 22}, 052105 (2010)), we considered two flow, finding formation surface waves whose properties within implemented long wave model depend on single parameter, $D=(3Ca)^{1/3}\cot\alpha$, where $Ca$ is capillary number and $\alpha$ inclination angle. present consider fully 3D setting discuss influence additional...
Abstract Pathogenic bacteria, including drug-resistant variants such as methicillin-resistant Staphylococcus aureus (MRSA), can cause severe infections in the human body. Early detection of MRSA is essential for clinical diagnosis and proper treatment, considering distinct therapeutic strategies methicillin-sensitive S. (MSSA) infections. However, similarities between MSSA properties present a challenge promptly accurately distinguishing them. This work introduces an approach to...
We propose a physics-aware Consistency Training (CT) method that accelerates sampling in Diffusion Models with physical constraints. Our approach leverages two-stage strategy: (1) learning the noise-to-data mapping via CT, and (2) incorporating physics constraints as regularizer. Experiments on toy examples show our generates samples single step while adhering to imposed This has potential efficiently solve partial differential equations (PDEs) using deep generative modeling.
A mesoscopic continuum model is employed to analyze the transport mechanisms and structure formation during redistribution stage of deposition experiments where organic molecules are deposited on a solid substrate with periodic stripe-like wettability patterns. Transversally invariant ridges located more wettable stripes identified as very important transient states their linear stability analyzed accompanied by direct numerical simulations fully nonlinear evolution equation for...
The motion of an autophoretic spherical particle in a simple fluid is analyzed. This powered by chemical species which absorbed or emitted the and diffuses advected surrounding fluid. transition from nonmotile to motile state occurs if Péclet number Pe (defined as ratio solute emission rate over diffusion rate) sufficiently large. We first analyze axisymmetric case (restricting unique direction). In this case, we find that transits motionless directed at given critical Pe. Increasing Pe,...
DNA gyrase is the only topoisomerase capable of introducing (−) supercoils into relaxed DNA. The C-terminal domain A subunit (GyrA-CTD) and presence a gyrase-specific ‘GyrA-box’ motif within this are essential for unique supercoiling activity by allowing to wrap around itself. Here we report crystal structure Xanthomonas campestris GyrA-CTD provide first view canonical GyrA-box motif. This resembles GyrA-box-disordered Escherichia coli GyrA-CTD, both adopting non-planar β-pinwheel fold...
We study spreading dynamics of nematic liquid crystal droplets within the framework long-wave approximation. A fourth order nonlinear parabolic partial differential equation governing free surface evolution is derived. The influence elastic distortion energy and imposed anchoring variations at substrate are explored through linear stability analysis scaling arguments, which yield useful insight predictions for behaviour droplets. This captured by fully time-dependent simulations three...
We discuss the behavior of partially wetting liquids on a rotating cylinder using model that takes into account effects gravity, viscosity, rotation, surface tension and wettability. Such system can be considered as prototype for many other systems where interplay spatial heterogeneity lateral driving force in proximity first- or second-order phase transition results intricate behavior. So does drop undergo depinning rotation speed is increased, whereas ideally \bfuwe{only changes...
A unified and computationally efficient SPICE model for accurate prediction of the I-V characteristics small-geometry lightly doped drain (LDD) MOSFETs is described. It based on enhancement LEVEL3 MOS a novel parameter extraction method. supports design both short-channel narrow-gate-width LDD with any kind channel or field implant. semiempirical approach to modeling threshold voltage MOSFETs, in which effect implemented, demonstrated. The applicable effective lengths widths down...
We discuss the long-wave hydrodynamic model for a thin film of nematic liquid crystal in limit strong anchoring at free surface and substrate. rigorously clarify how elastic energy enters evolution equation thickness order to provide solid basis further investigation: several conflicting models exist literature that predict qualitatively different behaviour. consolidate various approaches show derived through an asymptotic expansion full nemato-hydrodynamic equations with consistent boundary...
A series of experiments [C. Poulard and A. M. Cazabat, “Spontaneous spreading nematic liquid crystals,” Langmuir 21, 6270 (2005)] on droplets crystal (NLC) reveals a surprisingly rich variety behaviors. Small can either be arrested in their spreading, spread stably, destabilize without (corrugated surface), or with fingering instability corrugated free surface. In this work, we discuss the problem NLC drops simplified two-dimensional (2D) geometry. The model that present is based...
Abstract Peptidoglycan (PG) sacculi surround the cytoplasmic membrane, maintaining cell integrity by withstanding internal turgor pressure. During growth, PG endopeptidases cleave crosslinks of fully closed sacculi, allowing for incorporation new glycan strands and expansion peptidoglycan mesh. Outer-membrane-anchored NlpI associates with hydrolases synthases near synthesis complexes, facilitating spatially close hydrolysis. Here, we present structure adaptor in complex endopeptidase MepS,...