A5034757601- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Medical Imaging and Pathology Studies
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Streptococcal Infections and Treatments
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infectious Diseases and Mycology
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Hematological disorders and diagnostics
- Vibrio bacteria research studies
- Intestinal Malrotation and Obstruction Disorders
- Actinomycetales infections and treatment
- Cerebrovascular and Carotid Artery Diseases
- Antibiotic Resistance in Bacteria
- Gastroesophageal reflux and treatments
National Cheng Kung University Hospital
2019-2025
Institute of Clinical Research
2025
National Cheng Kung University
2019-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2025
National Taiwan University
2004-2016
National Taiwan University Hospital
2004-2016
Fu Jen Catholic University
2010-2014
Taipei City Hospital
2011-2014
Chi Mei Medical Center
2010-2014
National Defense Medical Center
2014
Background and objective: Bacterial infection is one of the major causes acute exacerbation COPD (AECOPD). This study was undertaken to investigate microbiology AECOPD. Methods: Medical records from 494 episodes AECOPD in patients admitted National Taiwan University Hospital January 2000 June 2004 were reviewed. Severity classified according 2003 Global Initiative for Chronic Obstructive Lung Disease guideline. Results: Potential pathogenic microorganisms isolated 328 (66.4%) The predominant...
Dual antiplatelet therapy (DAPT) is the standard treatment for acute myocardial infarction (MI). This study aimed to investigate use of DAPT and de-escalation after discharge in real-world practice among patients with MI undergoing percutaneous coronary intervention (PCI) Taiwan. Using Taiwan National Health Insurance Research Database, we included who received PCI survived from 2011 2021. The choice different P2Y12 inhibitors at were analyzed. Overall, 58989 (mean age 61.9 ± 13.2 years,...
Abstract Background Crohn’s disease (CD) is a progressive condition, and early treatment with infliximab combined an immunosuppressant within six months has been shown to improve clinical outcomes. However, the impact of ustekinumab (UST) use in biologic-naïve CD patients remains unclear. This study aims address this gap by evaluating outcomes UST intervention such patients. Methods In retrospective cohort study, we included treated UST, follow-up period at least months, from October 2020...
To explore the mechanism of Lacticaseibacillus paracasei E6 for improving vinorelbine-induced immunosuppression in zebrafish. The intestinal colonization L. labeled by fluorescein isothiocyanate (FITC) zebrafish was observed under fluorescence microscope. In a model immunosuppression, immunomodulatory activity assessed analyzing macrophage and neutrophil counts caudal hematopoietic tissue (CHT), number T-lymphocyte, expressions interleukin-12 (IL-12) interferon-γ (IFN-γ). contents...
Abstract Background Advances in the understanding of idiopathic pulmonary fibrosis (IPF) and international cooperation have led to publication subsequent updates practice guidelines. The impact these guidelines, especially significant occurring after 2011, on IPF epidemiology clinical practices remains relatively unexplored. Methods This retrospective nationwide population-based study utilized Whole-Population Datafiles (WPD) Taiwan’s National Health Insurance Research Database that...
To investigate the determinants of outcome in patients with persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia.All >or=18 years old MRSA bacteraemia for >or=7 days from 2000 to 2008 treated at National Taiwan University Hospital were investigated. The associations mortality clinical characteristics, management and vancomycin MICs serial isolates analysed.Persistent occurred 227 patients. Decreasing trends incidence (P < 0.001) = 0.031) found. Elevated subsequent found...
SUMMARY Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus. Methods Between 1989 and 1993, 431 men 181 women with were given cardiovascular reflex (CVR) tests. These subjects followed for the subsequent 5–9 years assess rates. Results The prevalence rate of abnormal CVR tests was 46.1% patients history less than 5 up 69.4% when exceeded 20 years. During follow‐up period from 1 January 31 December 1997 (mean 7.7...
SUMMARY In contrast to bacteraemic pneumococcal community-acquired pneumonia (CAP), there is a paucity of data on the clinical characteristics and outcomes non-bacteraemic CAP. This retrospective study compared outcome hospitalized patients with CAP treated at medical centre from 2004 2008. Data including all-cause mortality, length hospital stay, need for intensive-care unit admission extrapulmonary involvement were analysed. all, 221 (87 bacteraemic, 134 non-bacteraemic) included. Patients...
Nintedanib is effective for treating idiopathic pulmonary fibrosis (IPF), but some patients may exhibit a suboptimal response and develop on-treatment acute exacerbation (AE-IPF), hepatic injury, or mortality. It remains unclear which are at risk these adverse outcomes.
It is essential to investigate the serotype distribution of pneumococcal diseases in each region and its associated clinical features. This study investigated annual incidence invasive disease (IPD) serotypes isolates causing IPD at a medical center northern Taiwan during period 2000 2012.Serotypes all available Streptococcus pneumoniae were determined using latex agglutination test.During period, (per 10,000 admissions) decreased significantly from 9.8 2.1 2012 (P < 0.001). The all-cause...
SUMMARY This multicentre surveillance study was conducted to investigate the trends in incidence and aetiology of healthcare-associated bloodstream infections (HCA-BSIs) Taiwan. From 2000 2011 a total 56 830 HCA-BSIs were recorded at three medical centres, coagulase-negative staphylococci (CoNS) most common pathogens isolated ( n = 9465, 16·7%), followed by E. coli 7599, 13·4%). The all each hospitals significantly increased over period owing increase aerobic Gram-positive cocci...