A5017303641- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Phytochemical compounds biological activities
- Garlic and Onion Studies
- Bioactive Compounds and Antitumor Agents
- Cancer Mechanisms and Therapy
- Berberine and alkaloids research
- Curcumin's Biomedical Applications
- Cancer-related Molecular Pathways
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Phytochemistry and biological activity of medicinal plants
- NF-κB Signaling Pathways
- Gallbladder and Bile Duct Disorders
- Cancer therapeutics and mechanisms
- Amoebic Infections and Treatments
- Tannin, Tannase and Anticancer Activities
- Natural Compounds in Disease Treatment
- DNA Repair Mechanisms
- Beetle Biology and Toxicology Studies
- Glutathione Transferases and Polymorphisms
- Flavonoids in Medical Research
- Autophagy in Disease and Therapy
- Appendicitis Diagnosis and Management
- Cancer, Lipids, and Metabolism
China Medical University
2014-2024
Chung Hwa University of Medical Technology
2015-2024
China Medical University Beigang Hospital
2012-2023
China Medical University Hospital
2005-2016
National Yang Ming Chiao Tung University
2010-2016
Chung Shan Medical University
2005-2011
China Medical University
2009-2011
Tungs' Taichung MetroHarbor Hospital
2009
Chung Shan Medical University Hospital
2005
Benzyl isothiocyanate (BITC), a component of dietary cruciferous vegetables, has antioxidant and anticancer properties. In this study, we show for the first time antimetastatic effects BITC in human colon cancer HT29 cells. had an inhibitory effect on cell migration invasion. Protein levels matrix metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), urokinase-plasminogen activator (u-PA) were reduced by concentration-dependent manner. also exerted phosphorylation c-Jun N-terminal kinase...
Numerous studies have shown that rutin has anticancer effects. We previously reported induced cell cycle arrest and apoptosis in murine leukemia WEHI-3 cells vitro vivo. However, there are no data showing inhibits human HL-60 vivo a xenograft animal model. Human were implanted into mice treated with vehicle (1% DMSO), (120 mg/kg of body weight) or vinblastine μg/kg weight). Compounds agents injected once every four days intraperitoneally (i.p.) for 36 days. Treatment 120 resulted reduction...
Abstract Genistein, a major isoflavone compound in soybeans, has been shown to have biological activities including anti‐cancer activates. In the present, we investigated anti‐leukemia activity of genistein on HL‐60 cells vitro. The percentage viable cell, cell cycle distribution, apoptotic death, reactive oxygen species (ROS), and Ca 2+ production level Δ Ψ m were measured by flow cytometric assay. Cell apoptosis endoplasmic reticulum (ER) stress associated protein expressions examined...
Capsaicin was reported to inhibit cancer cell growth. The aim of this study evaluate the antitumor potential capsaicin by studying activity in vitro as well vivo. studies are examine effects on human colon colo 205 cells after exposure capsaicin. results showed that induced cytotoxic a time- and dose-dependent manner increased reactive oxygen species (ROS) Ca2+ but decreased level mitochondrial membrane (ΔΨm) cells. Data from Western blotting analysis indicated levels Fas, cytochrome c,...
Diallyl sulfide (DAS), diallyl disulfide (DADS), and trisulfide (DATS) are major organosulfur compounds exiting in garlic (Allium sativum). These reported to exhibit various pharmacological properties such as antibacteria, antiangiogenesis, anticancer, anticoagulation, they also induce cytotoxicity induction of apoptosis human cancer cells. Although these show wide spectrum biological activities, there no reports that DAS, DADS, DATS affected migration invasion colon cells, their exact...
Sulforaphane (SFN), an isothiocyanate, exists exclusively in cruciferous vegetables, and has been shown to possess potent antitumor chemopreventive activity. However, there is no available information that shows SFN affecting human colon cancer HCT 116 cells. In the present study, we found induced cell morphological changes, which were photographed by contrast-phase microscopy, decreased viability. also G2/M phase arrest apoptosis cells, measured with flow cytometric assays. Western blotting...
Abstract Enhanced flavonoid consumption is closely related with a reduced cancer incidence as shown in epidemiological studies. Quercetin (3,5,7,3′,4′‐pentahydroxylflavone) one of the active components flavonoids which exist natural plants, particularly onions and fruits. It was reported that quercetin induced apoptosis human cell lines, including leukemia HL‐60 cells, but there no available information to its effects on cells vivo . The purpose present studies focus WEHI‐3 cells. injected...
Cantharidin has shown potent anticancer activities on many types of human cancer cells. This study was performed to elucidate whether mitochondria and caspases are involved in the modulation apoptosis cell cycle arrest by cantharidin bladder The effect arrest, apoptosis, caspases, reactive oxygen species (ROS) mitochondrial membrane potential (ΔΨ(m)) were measured flow cytometry, levels apoptosis-associated proteins its regulatory molecules studied Western blotting. Cantharidin-induced DNA...
Metastasis suppressors and associated other regulators of cell motility play a critical initial role in tumor invasion metastases. Benzyl isothiocyanate (BITC) is hydrolysis compound glucotropaeolin dietary cruciferous vegetables. BITC has been found to exhibit prevention cancers laboratory animals might also be chemoprotective humans. Here, the purpose this study was investigate effects on proliferation, migration, mitogen-activated protein kinase (MAPK) pathways AGS human gastric cancer...
Abstract Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis‐dependent diseases including cancer. We examined cytotoxic, anti‐metastatic, anti‐cancer anti‐angiogenic effects diallyl trisulfide ( DATS ). In HT 29 cells, inhibited migration invasion through inhibition focal adhesion kinase FAK ), extracellular signal‐regulated kinase, c‐Jun N‐terminal p38 which was associated with matrix metalloproteinases‐2, ‐7 ‐9 VEGF . human umbilical vein endothelial...