A5076009573- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Inflammatory Bowel Disease
- Organ Donation and Transplantation
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Peptidase Inhibition and Analysis
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Zhengzhou University
2013-2025
Sichuan University
2023-2025
West China Hospital of Sichuan University
2025
Zhengzhou University
2007-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
ARC Centre of Excellence for Plant Success in Nature and Agriculture
2024
Agriculture and Food
2024
The University of Queensland
2024
Sir Run Run Shaw Hospital
2024
Beijing Hospital
2019-2022
Background and Aims Hepatic ischemia‐reperfusion (I/R) injury, which mainly involves inflammatory responses apoptosis, is a common cause of organ dysfunction in liver transplantation (LT). As critical mediator inflammation apoptosis various cell types, the role tripartite motif‐containing (TRIM) 27 hepatic I/R injury remains worthy study. Approach Results This study systemically evaluated putative TRIM27/transforming growth factor β–activated kinase 1 (TAK1)/JNK (c‐Jun N‐terminal kinase)/p38...
Liver resection and liver transplantation are the treatment modalities with greatest potential for curing hepatocellular carcinoma (HCC). Tumor recurrence after HCC is, however, a major problem, an increased rate of living donor versus cadaveric whole has been suggested. Factors involved in regeneration may stimulate growth occult tumors. The aim this project was to test hypothesis that microscopic tumor setting partial hepatectomy would show enhanced signs invasiveness corresponding size...
Abstract Background The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. HER2 could be a new target as treatment option for HCC well tumor recurrence after surgery. biology needs further explorations. Methods Clinical and mRNA data patients were obtained from TCGA cohort, GSE89377 GSE115018. Western Blotting immunohistochemistry employed to test expression HER2,...
Background and Aims Hepatic ischemia‐reperfusion (I/R) injury remains a major challenge affecting the morbidity mortality of liver transplantation. Effective strategies to improve function after hepatic I/R are limited. Six‐transmembrane epithelial antigen prostate 3 (Steap3), key regulator iron uptake, was reported be involved in immunity apoptotic processes various cell types. However, role Steap3 I/R‐induced damage largely unclear. Approach Results In present study, we found that...
Hepatic ischemia-reperfusion (HIR) injury, a common clinical complication of liver transplantation and resection, affects patient prognosis. Ring finger protein 5 (RNF5) is an E3 ubiquitin ligase that plays important roles in endoplasmic reticulum stress, unfolded reactions, inflammatory responses; however, its role HIR unclear.RNF5 expression was significantly down-regulated during mice hepatocytes. Subsequently, RNF5 knockdown overexpression cell lines were subjected to...
Mounting evidence has revealed that the interactions and dynamic alterations among immune cells are critical in shaping tumor microenvironment ultimately map onto heterogeneous clinical outcomes. Currently, underlying significance of cell evolutions remains largely unexplored hepatocellular carcinoma (HCC). A total 3,817 1,750 HCC patients 15 independent public datasets were retrieved. The Seurat Monocle algorithms used to depict T evolution, nonnegative matrix factorization (NMF) was...
Abstract Liver ischemia–reperfusion (IR) injury is a common complication following liver surgery, significantly impacting the prognosis of transplantation and other surgeries. Betaine‐homocysteine methyltransferase (BHMT), crucial enzyme in methionine cycle, has been previously confirmed pivotal role hepatocellular carcinoma, it also demonstrated that BHMT inhibits inflammation, apoptosis, but its IR remains unknow. Following I/R injury, we found expression was upregulated human transplant...
Osteosarcoma (OS) is the most common primary bone malignancy with variable molecular biology and prognosis. However, our understanding of association between cell types OS progression remains poor. We generated a human atlas by integrating over 110,000 single cells from 17 samples. Multiple machine learning algorithms were applied to develop tumor purity prediction models based on transcriptomic profile OS. The Scissor algorithm gene enrichment analyses conducted delve into cell-intrinsic...
To investigate the early dynamic changes of biomarkers associated with capillary leak syndrome (CLS) in patients severe acute pancreatitis (SAP) and their correlation multiple organ failure (MOF). A total 171 SAP admitted to West China Centre Excellence for Pancreatitis, Hospital, Sichuan University between September 1, 2019 December 31, 2020 were enrolled this study. The divided into MOF non-MOF groups based on occurrence first 5 days hospitalization, further subgroups presence...
Vonoprazan fumarate is a potassium-competitive acid blocker that was developed as novel acid-suppressing drug for multiple indications. As potential alternative to proton-pump inhibitors, the determination of drug-drug interactions vital further applications. Probe cocktails are type rapid, economical, and efficient approach evaluating cytochrome P450 enzyme activities. Since vonoprazan metabolized partly by P450, were used study CYP-based interactions.This conducted both in vitro vivo. In...
Abstract Background and Aims Hepatic ischemia–reperfusion injury (IRI) is a common complication of hepatectomy liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Regulator G‐protein signaling 14 (RGS14) multifunctional scaffolding protein that integrates mitogen‐activated kinase (MAPK) pathways. role RGS14 in remains unclear. Approach Results We found expression increased mice subjected to (IR) surgery during hypoxia reoxygenation...
Background and Aim: Bromodomain extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention the field of cancer therapeutics. have been found to be overexpressed HCC cells tumor tissues. However, biological activity BET-PROTACs hepatocellular carcinoma (HCC) remains unclear. In this study, we investigated anti-HCC BETd-260, a BET-PROTAC...
Abstract Since the outbreak of COVID-19 in China at end 2019, world has experienced a large-scale epidemic caused by SARS-CoV-2. The epidemiological and clinical course patients been reported, but there have few analyses about characteristics, predictive risk factors, outcomes critical patients. In this single-center retrospective case–control study, 90 adult inpatients hospitalized Tongji Hospital (Wuhan, China) were included. Demographic, clinical, laboratory tests, treatment data obtained...
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies with complex phenotypic, etiological, biological, clinical heterogeneities. Previous studies have proposed different clinically relevant subtypes HNSCC, but little known about its corresponding prognosis or suitable treatment strategy. Here, we identified 101 core genes from three prognostic pathways, including mTORC1 signaling, unfold protein response, UV response UP, in 124 pairs tumor matched normal...
Hepatocellular carcinoma (HCC) is the sixth most common cancer and fourth leading cause of tumor-related deaths worldwide. N6-methyladenosine (m6 A) mediates RNA metabolism in tumor biology. However, regulatory role YTHDF3, an m6 A reader, HCC progression its underlying mechanisms remains unclear. Therefore, this study aims to investigate oncogenic effect YTHDF3 on via epigenetic regulation A-modified mRNAs. The expression levels tissues matched adjacent liver were detected using western...
Parkinson's disease (PD) is the second most common neurodegenerative but still lacks a preclinical strategy to identify it. The diagnostic value of intestinal mucosal α-synuclein (αSyn) in PD has not drawn uniform conclusion. relationship between alteration αSyn expression and microbiota unclear. Nineteen patients twenty-two healthy controls were enrolled our study from whom collected, using gastrointestinal endoscopes, duodenal sigmoid samples for biopsy. Multiplex immunohistochemistry was...
Oxidative stress following liver ischemia/reperfusion (I/R) is an important pathological mechanism responsible for injury. Veratric acid (VA) a phenolic benzoic that has been reported to have antioxidant properties. However, whether VA protective effects against I/R injury remains unclear. In the present study, mouse model was established. administered intragastrically one week before I/R. Biochemical indicators, histological analysis, cell apoptosis, oxidative stress, and pathway proteins...
The underlying mechanism of liver regeneration after Associating Liver Partition and Portal vein ligation (PVL) for Staged hepatectomy (ALPPS) is still unclear. aim this study was to evaluate the relationship between future remnant (FLR) volume, characteristics restoration function in an experimental model ALPPS.An ALPPS rats developed with selective PVL, parenchymal transection partial (step 1), followed by resection 2). Three different groups FLR sizes 30, 20 10 per cent total volume were...
Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development cholestatic disease, but underlying molecular mechanism not clear. The purpose this study was to investigate mechanisms Sirt6 protection against human intrahepatic cells (HiBEC) induced acid glycochenodeoxycholate (GCDC).Sirt6 either overexpressed or knocked down HiBEC, with without GCDC pretreatment. CCK-8 assay used assess viability and, Hoechst 33258 staining determine apoptotic rate....