A5019001658- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Ginger and Zingiberaceae research
- Drug-Induced Hepatotoxicity and Protection
- interferon and immune responses
- Sirtuins and Resveratrol in Medicine
- Organ and Tissue Transplantation Research
- Metabolism and Genetic Disorders
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Bioactive Natural Diterpenoids Research
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Lipid metabolism and biosynthesis
Hefei University of Technology
2025
First Affiliated Hospital of Zhengzhou University
2013-2024
Ningbo No. 2 Hospital
2024
Changzhou University
2024
Xiamen University
2009-2016
Zhengzhou University
2013
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2012
Second Affiliated Hospital of Zhejiang University
2012
Zhongshan Hospital of Xiamen University
2009
// Wenzhi Guo 1 , Jiakai Zhang Dongyu 2 Shengli Cao Gongquan Li Shuijun Zhihui Wang Peihao Wen Han Yang Xiaoyi Shi Jie Pan and Hua Ye 3 Department of Hepatic Biliary Pancreatic Surgery, Henan Key Laboratory Digestive Organ Transplantation, The First Affiliated Hospital Zhengzhou University, Zhengzhou, Henan, P.R. China Infectious Disease, College Public Health, Correspondence to: Guo, email: guoweizhi@aliyun.com Ye, yehuazz@aliyun.com Keywords: circ-ITCH, hepatocellular carcinoma,...
Abstract Acetaminophen (APAP) overdose is a major cause of drug‐induced liver injury. Sirtuins 5 (SIRT5) has been implicated in the development various diseases. However, its involvement APAP‐induced acute injury (AILI) remains unclear. The present study aimed to explore role SIRT5 AILI. expression dramatically downregulated by APAP administration mouse livers and AML12 hepatocytes. deficiency not only exacerbates inflammatory response, but also worsens mitochondrial oxidative stress....
Background and Aims Hepatic ischemia‐reperfusion (I/R) injury, which mainly involves inflammatory responses apoptosis, is a common cause of organ dysfunction in liver transplantation (LT). As critical mediator inflammation apoptosis various cell types, the role tripartite motif‐containing (TRIM) 27 hepatic I/R injury remains worthy study. Approach Results This study systemically evaluated putative TRIM27/transforming growth factor β–activated kinase 1 (TAK1)/JNK (c‐Jun N‐terminal kinase)/p38...
Background and Aims Hepatic ischemia‐reperfusion (I/R) injury remains a major challenge affecting the morbidity mortality of liver transplantation. Effective strategies to improve function after hepatic I/R are limited. Six‐transmembrane epithelial antigen prostate 3 (Steap3), key regulator iron uptake, was reported be involved in immunity apoptotic processes various cell types. However, role Steap3 I/R‐induced damage largely unclear. Approach Results In present study, we found that...
Hepatic ischemia-reperfusion (HIR) injury, a common clinical complication of liver transplantation and resection, affects patient prognosis. Ring finger protein 5 (RNF5) is an E3 ubiquitin ligase that plays important roles in endoplasmic reticulum stress, unfolded reactions, inflammatory responses; however, its role HIR unclear.RNF5 expression was significantly down-regulated during mice hepatocytes. Subsequently, RNF5 knockdown overexpression cell lines were subjected to...
Background and Aim: Bromodomain extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention the field of cancer therapeutics. have been found to be overexpressed HCC cells tumor tissues. However, biological activity BET-PROTACs hepatocellular carcinoma (HCC) remains unclear. In this study, we investigated anti-HCC BETd-260, a BET-PROTAC...
Abstract Background and Aims Hepatic ischemia–reperfusion injury (IRI) is a common complication of hepatectomy liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Regulator G‐protein signaling 14 (RGS14) multifunctional scaffolding protein that integrates mitogen‐activated kinase (MAPK) pathways. role RGS14 in remains unclear. Approach Results We found expression increased mice subjected to (IR) surgery during hypoxia reoxygenation...
Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development cholestatic disease, but underlying molecular mechanism not clear. The purpose this study was to investigate mechanisms Sirt6 protection against human intrahepatic cells (HiBEC) induced acid glycochenodeoxycholate (GCDC).Sirt6 either overexpressed or knocked down HiBEC, with without GCDC pretreatment. CCK-8 assay used assess viability and, Hoechst 33258 staining determine apoptotic rate....
Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC), but role RhoA-YAP1-autophagy pathway in HCC remains unclear. Due to core liver cancer stem cells (LCSCs) and recurrence, we explored LCSCs under FSS. Our results indicate that have stronger proliferation cell spheroidization abilities. FSS (1 dyn/cm2) upregulated migration autophagy protein markers, inducing LC3B aggregation autophagosome formation LCSCs. Mechanistically, promoted YAP1 dephosphorylation...
The mechanisms underlying severe liver injury after brain-dead (BD) donor transplantation (BDDLT) remain unclear. In this study, we aimed to explore the roles of lncRNAs and circRNAs in BDDLT. Rat was detected sham, BD, control, BDDLT groups. We examined expression profiles livers control group using microarray analysis. main functions differentially expressed genes were analyzed by gene ontology (GO) KEGG pathway enrichment addition, used bioinformatic analyses construct related networks....
Abstract Although the death of hepatocytes is a crucial trigger liver ischemia–reperfusion (I/R) injury, regulation I/R-induced hepatocyte still poorly understood. Phosphoglycerate mutase 5 (PGAM5), mitochondrial Serine/Threonine protein phosphatase, regulates dynamics and involved in process both apoptosis necrotic. However, it unclear what role PGAM5 plays induced by I/R. Using PGAM5-silence mice model, we investigated I/R injury its relevant molecular mechanisms. Our data showed that was...
Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated role of caspase-1-mediated pyroptosis in BD-induced kidney injury rats. A BD model was established Sprague-Dawley The rats were intravenously injected with Z-YVAD-FMK 1 h before BD, and sham-operated served as controls. After 0, 1, 2, 4, 6 renal injury, expression nod-like receptor family pyrin domain-containing 3 (NLRP3), caspase-1,...
Ischemia/reperfusion (I/R)‑induced liver injury remains a primary concern in transplantation and hepatectomy. Previous studies have indicated that microRNAs (miRs) are involved multiple pathophysiological processes, including I/R. miR‑140‑5p reportedly inhibits inflammatory responses apoptosis several diseases; however, the role of I/R unknown. The present study aimed to investigate potential mechanism on injury. Mouse mouse AML12 cell hypoxia/reoxygenation (H/R) models were established....
<title>Abstract</title> Background Dysnatremia is common in donors and recipients of liver transplantation (LT). However, the influence dysnatremia on LT prognosis remains controversial. This study aimed to investigate effects paired donors’ recipients’ serum sodium prognosis. Methods We retrospectively reviewed 248 patients who underwent orthotopic at our center between January 2016 December 2018. Donors perioperative 3-year postoperative clinical data were included. Delta was defined as...
Objective: Study the therapeutic effects and immunoregulatory mechanisms of anti-DR5 mAb on adjuvant arthritis (AA) rats. Methods: AA rats induced by CFA, were treated with through mainline administration. Effect synovial membranes tissues was detected H&E staining. Flow cytometry MTT assay used for detecting apoptosis in an vitro system TUNEL analysis vivo system. The involvement apoptotic pathway further proved a caspase inhibition assay. Results: Anti-DR5 could induce cell system,...