A5028667107- Diet and metabolism studies
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Lipid metabolism and biosynthesis
- Chronic Lymphocytic Leukemia Research
- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Image and Signal Denoising Methods
- Clinical Nutrition and Gastroenterology
- RNA modifications and cancer
- Liver physiology and pathology
- Protein Kinase Regulation and GTPase Signaling
- Genomics, phytochemicals, and oxidative stress
- Atherosclerosis and Cardiovascular Diseases
- RNA Research and Splicing
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- Advanced Image Processing Techniques
- Advanced Image Fusion Techniques
- Hippo pathway signaling and YAP/TAZ
First Affiliated Hospital of Zhengzhou University
2021-2024
Zhengzhou University
2022-2024
Nanyang Institute of Technology
2022
Xi'an University of Science and Technology
2021
<abstract><p>The image super-resolution reconstruction method can improve the quality in Internet of Things (IoT). It improves data transmission efficiency, and is great significance to encryption. Aiming at problem low using neural networks, a self-attention-based proposed for secure IoT environment. The network model improved, residual structure sub-pixel convolution are used extract feature image. self-attention module detailed information Using generative confrontation...
Abstract Background and Aims Hepatic ischemia–reperfusion injury (IRI) is a common complication of hepatectomy liver transplantation. However, the mechanisms underlying hepatic IRI have not been fully elucidated. Regulator G‐protein signaling 14 (RGS14) multifunctional scaffolding protein that integrates mitogen‐activated kinase (MAPK) pathways. role RGS14 in remains unclear. Approach Results We found expression increased mice subjected to (IR) surgery during hypoxia reoxygenation...
Oxidative stress following liver ischemia/reperfusion (I/R) is an important pathological mechanism responsible for injury. Veratric acid (VA) a phenolic benzoic that has been reported to have antioxidant properties. However, whether VA protective effects against I/R injury remains unclear. In the present study, mouse model was established. administered intragastrically one week before I/R. Biochemical indicators, histological analysis, cell apoptosis, oxidative stress, and pathway proteins...
Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC), but role RhoA-YAP1-autophagy pathway in HCC remains unclear. Due to core liver cancer stem cells (LCSCs) and recurrence, we explored LCSCs under FSS. Our results indicate that have stronger proliferation cell spheroidization abilities. FSS (1 dyn/cm2) upregulated migration autophagy protein markers, inducing LC3B aggregation autophagosome formation LCSCs. Mechanistically, promoted YAP1 dephosphorylation...
Liquid-liquid phase separation (LLPS) is a reversible process, during which biological macromolecules, including proteins and nucleic acids, condense into liquid membraneless organelles under the influence of weak multivalent interactions. Currently, fluorescence recovery after photobleaching primary method used to detect macromolecules. Recent studies have revealed link between abnormal LLPS pathogenesis development various human cancers. Through or separation, tumor-related such as mRNA,...
Abstract Astaxanthin (ASX) is an oxygen‐containing non‐vitamin A carotenoid pigment. However, the role of ASX in autoimmune hepatitis (AIH) remains unclear. In this study, a mouse model AIH established induced by concanavalin (ConA). Mass cytometry and single‐cell RNA sequencing (scRNA‐seq) are used to analyze potential regulating immune microenvironment AIH. treatment effectively alleviated liver damage ConA downregulated pro‐inflammatory cytokines production mice. scRNA‐seq analyses...
End-ischemic normothermic mechanical perfusion (NMP) could provide a curative treatment to reduce cholestatic liver injury from donation after circulatory death (DCD) in donors. However, the underlying mechanism remains elusive. Our previous study demonstrated that air-ventilated NMP improve functional recovery of DCD preclinical rat model. Here, metabolomics analysis revealed alleviated DCD- and cold preservation-induced injury, as shown by elevated release alanine aminotransferase (ALT),...
Whether a causative link exists between brain death (BD) and intestinal microbiota dysbiosis is unclear, the distortion in liver metabolism associated with BD requires further exploration.A rat model of was constructed sustained for 9 h (BD group, n=6). The sham group (n=6) underwent same procedures, but catheter inserted into epidural space without ballooning. Intestinal contents portal vein plasma were collected sequencing microbial metabolite detection. Liver tissue resected to...
ABSTRACT Background The causative link between brain death and intestinal microbiota dysbiosis is unclear, the distortion in liver metabolism caused by requires further exploration. Material Methods A rat model of was constructed sustained for 9 hours. Intestinal contents portal vein plasma were collected sequencing microbial metabolite detection. Liver tissue resected to investigate metabolic alterations, results compared with those a sham group. Results Microbiota occurred at family genus...
Abstract Background: The causative link between brain death and intestinal microbiota dysbiosis is unclear, the distortion in liver metabolism caused by requires further exploration. Methods: A rat model of was constructed sustained for 9 hours. Intestinal contents portal vein plasma were collected sequencing microbial metabolite detection. Liver tissue resected to investigate metabolic alterations, results compared with those a sham group. Results: Microbiota occurred at family genus levels...