A5033243546- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Pancreatic and Hepatic Oncology Research
- Delphi Technique in Research
- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Acute Ischemic Stroke Management
- Peroxisome Proliferator-Activated Receptors
- Sarcoidosis and Beryllium Toxicity Research
- Acute Myocardial Infarction Research
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Glycosylation and Glycoproteins Research
- Cardiac, Anesthesia and Surgical Outcomes
- Health Sciences Research and Education
- Meta-analysis and systematic reviews
- Gastrointestinal disorders and treatments
- Acute Kidney Injury Research
- Ferroptosis and cancer prognosis
- Viral-associated cancers and disorders
- Radiology practices and education
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromatin Remodeling and Cancer
- Neurological Complications and Syndromes
Royal United Hospital
2025
China Medical University
2025
Zhengzhou University
2015-2022
First Affiliated Hospital of Zhengzhou University
2019-2022
The Christie Hospital
2021
Christie's
2021
University of Manchester
2021
Manchester Royal Infirmary
2019-2020
Manchester University NHS Foundation Trust
2019-2020
Manchester Academic Health Science Centre
2019-2020
Abstract Background The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. HER2 could be a new target as treatment option for HCC well tumor recurrence after surgery. biology needs further explorations. Methods Clinical and mRNA data patients were obtained from TCGA cohort, GSE89377 GSE115018. Western Blotting immunohistochemistry employed to test expression HER2,...
Background and Aims Hepatic ischemia‐reperfusion (I/R) injury remains a major challenge affecting the morbidity mortality of liver transplantation. Effective strategies to improve function after hepatic I/R are limited. Six‐transmembrane epithelial antigen prostate 3 (Steap3), key regulator iron uptake, was reported be involved in immunity apoptotic processes various cell types. However, role Steap3 I/R‐induced damage largely unclear. Approach Results In present study, we found that...
Abstract Objectives Artificial intelligence (AI) software including Brainomix “e-CTA” which detect large vessel occlusions (LVO) have clinical potential. We hypothesised that in real world use where prevalence is low, its utility may be overstated. Methods In this single centre retrospective service evaluation project, data sent to from a medium size acute National Health Service (NHS) Trust hospital between 1/3/2022-1/3/2023 was reviewed. 584 intracranial computed tomography angiogram (CTA)...
Breast cancer remains the leading cause of cancer-related mortality among women globally. A significant challenge in lowering breast death rates is multidrug resistance. This resistance arises through various mechanisms, such as heightened drug efflux, improved DNA repair, escape from senescence, epigenetic modifications, tumor heterogeneity, alterations microenvironment (TME), and epithelial-to-mesenchymal transition (EMT). These factors collectively make overcoming particularly difficult....
Background and Aim: Bromodomain extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention the field of cancer therapeutics. have been found to be overexpressed HCC cells tumor tissues. However, biological activity BET-PROTACs hepatocellular carcinoma (HCC) remains unclear. In this study, we investigated anti-HCC BETd-260, a BET-PROTAC...
Merkel cell carcinoma (MCC) is a rare and highly aggressive primary cutaneous neuroendocrine carcinoma, most often occurring in the elderly. Recurrence frequent 40% of cases regional distant metastases develop. Despite this, there have been reports spontaneous regression. We report first case MCC with complete regression nose an 86-year-old woman following incisional biopsy.An presented violaceous lump on left side measuring 25×25mm. Incisional biopsy lesion showed immunohistochemistry...
The aim of this study was to identify novel biomarkers for the diagnosis of, and potential therapeutic targets for, hepatocellular carcinoma (HCC). Multilectin affinity chromatography used enrich N-linked glycoproteins from nontumorous liver HCC tissues followed by 2DE protein identification MS. Twenty-eight differentially expressed proteins were identified. Western blotting validated consistently lower concentrations human carboxylesterase 1 haptoglobin, higher concentration procathepsin D...
Prostate cancer, one of the most common malignant tumors in urology, now has become a disease that seriously threatens health men China. Although there are large number clinical studies on treatment patients with prostate many have entered advanced stage diagnosis, and little is known about its pathogenesis.We identified series ncRNA TF by differential expression analysis, co-expression enrichment connectivity hypergeometric test strategies for cancer genomes.53 modules related to PC-3 cells...
This study aimed to identify the underlying mechanisms in pancreatic cancer (PC) carcinogenesis and those as potential prognostic biomarkers, which can also be served new therapeutic targets of PC.Differentially expressed genes (DEGs) were identified between PC tumor tissues adjacent normal tissue samples from a public GSE62452 dataset, followed by functional pathway enrichment analysis. Then, protein-protein interaction (PPI) network was constructed prognosis-related screened based on PPI...
High aggressiveness is the main reason for poor prognosis of hepatocellular carcinoma (HCC) patients. However, its molecular mechanisms still remain largely unexplored. ACADL, a mitochondrial enzyme that facilitates primary regulated step in fatty acid oxidation, plays role HCC growth inhibition. function ACADL tumor metastasis not well elucidated. We found reduced expression closely associated with loss encapsulation, extrahepatic metastasis, and Upregulation significantly inhibited...
Hepatocellular carcinoma (HCC) is a common malignancy that associated with poor prognosis. The extensively studied TGF-β pathway mediated by SMAD proteins. FXR1, protein-coding gene belonging to the fragile X-related (FXR) family, involved in pathway. Previous studies have shown FXR1 promotes proliferation, invasion, and migration of colorectal cancer cells. aim present study was explore effects on HCC via TGF-β/SMAD signaling Immunohistochemical analysis used detect expression normal...
Spontaneous chylothorax remains an unusual condition with diverse aetiologies and non-unified management strategies. Owing to the rarity of condition, evidence from case reports limited retrospective studies. This represents a difficult-to-manage secondary yellow nail syndrome initial failure both surgical conservative treatment methods. Pleurovenous shunting approach allowing patient live control ongoing chyle leak.