A5089341284- Heme Oxygenase-1 and Carbon Monoxide
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- Alkaline Phosphatase Research Studies
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and disorders
- Drug-Induced Hepatotoxicity and Protection
First Affiliated Hospital of Zhengzhou University
2022-2024
Acute pancreatitis (AP) is a common emergency of the digestive system and serious cases can develop into severe acute (SAP), which ortality rates up to 30%. Sirtuin4 (SIRT4) member sirtuin family, plays key role in inflammation oxidative stress. However, potential SIRT4 SAP has yet be elucidated. In present study, we found that expression level human AP was downregulated by screening public database, suggesting may play AP. Subsequently, used L-arginine (L-Arg) induce knockout (SIRT4_KO)...
Abstract Acetaminophen (APAP) overdose is a major cause of drug‐induced liver injury. Sirtuins 5 (SIRT5) has been implicated in the development various diseases. However, its involvement APAP‐induced acute injury (AILI) remains unclear. The present study aimed to explore role SIRT5 AILI. expression dramatically downregulated by APAP administration mouse livers and AML12 hepatocytes. deficiency not only exacerbates inflammatory response, but also worsens mitochondrial oxidative stress....
Abstract Liver transplantation (LT) is the only effective method to treat end‐stage liver disease. Hepatic ischemia‐reperfusion injury (IRI) continues limit prognosis of patients receiving LT. Histone deacetylase 6 (HDAC6) a unique HDAC member involved in inflammation and apoptosis. However, its role mechanism hepatic IRI have not yet been reported. We examined HDAC6 levels tissue from LT patients, mice challenged with IRI, hepatocytes subjected hypoxia/reoxygenation (H/R). In addition,...
Abstract Acute pancreatitis is a common acute inflammatory abdominal disease. When progresses to severe (SAP), it can lead systemic inflammation and even multiple organ failure. Thioredoxin-interacting protein (TXNIP) an important involved in redox reactions of the response. However, specific role TXNIP SAP remains unclear. In this study, we investigated thioredoxin interacting when induced by high doses arginine. We found that pancreatic damage response associated with were largely...
<title>Abstract</title> Liver ischemia-reperfusion injury (LIRI) is an important cause of the clinical prognosis liver transplantation. Despite diverse roles that Sirtuin 4 (SIRT4) plays in posttranslational modifications, its specific involvement onset and progression LIRI remains unclear. The aim this research was to investigate influence SIRT4 on pathogenesis LIRI. In study, knockout liver-specific overexpression mice AML12 cells were used possible role Here, we showed expression...