A5080309265- Ultrasound and Hyperthermia Applications
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Fungal and yeast genetics research
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Reproductive Biology and Fertility
- Dietary Effects on Health
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Effects of Radiation Exposure
- Genomics and Chromatin Dynamics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Protein Kinase Regulation and GTPase Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Immunotherapy and Immune Responses
- Ovarian function and disorders
- Ubiquitin and proteasome pathways
- Bacteriophages and microbial interactions
- Asthma and respiratory diseases
- DNA Repair Mechanisms
- Cellular transport and secretion
University of Oxford
2021-2025
Beijing University of Chemical Technology
2025
Chongqing Medical University
2020-2024
Peking Union Medical College Hospital
2018-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2022
Beijing Institute of Petrochemical Technology
2021
Hebei Medical University
2020
Sun Yat-sen University
2020
Sun Yat-sen University Cancer Center
2020
Academy of Medical Sciences
2020
Abstract Rare diseases, affecting ~350 million people worldwide, pose significant challenges in clinical diagnosis due to the lack of experienced physicians and complexity differentiating between numerous rare diseases. To address these challenges, we introduce PhenoBrain, a fully automated artificial intelligence pipeline. PhenoBrain utilizes BERT-based natural language processing model extract phenotypes from texts EHRs employs five new diagnostic models for differential diagnoses The AI...
Background: Time-restricted feeding, also known as intermittent fasting, can confer various beneficial effects, especially protecting against obesity, and related metabolic disorders, but little is about the underlying mechanisms. Therefore, present study aims to investigate effects of time-restricted feeding on circadian rhythm gut microbiota hepatic metabolism. Methods: Eight-week-old male Kunming mice received either a normal diet ad libitum , high-fat or restricted an 8-h temporal window...
The interaction between RAS proteins and adenylyl cyclase was studied by using dominant interfering mutations of from the yeast Saccharomyces cerevisiae. activate in this organism. A plasmid expressing a catalytically inactive found to interfere dominantly with activation. region mapped leucine-rich repeat cyclase, which is homologous domains present several other thought participate protein-protein interactions.
Introduction/Aim Lung inhomogeneity measures obtained using computed cardiopulmonography (CCP) are sensitive to small-airways disease. Here, we assessed changes in lung patients with type-2 high asthma treated biological therapy and explored the relationship between conventional disease markers. Methods This was an observational study of 91 severe recruited from a tertiary clinic, whom 67 subsequently started anti-IL5 or anti-IL5R biologics. Patients were evaluated at baseline and, 54 those...
Schizosaccharomyces pombe contains a single gene, ras1, which is homolog of the mammalian RAS genes. ras1 required for conjugation, sporulation, and normal cell shape. has been previously identified as ste5. We report here gene we call byr2 that can encode predicted protein kinase partially suppress defects in mutants. mutant strains expressing high levels sporulate competently but are still defective conjugation abnormally round. mutants viable have shape absolutely sporulation. probably...
Abstract Since the outbreak of COVID-19 in China at end 2019, world has experienced a large-scale epidemic caused by SARS-CoV-2. The epidemiological and clinical course patients been reported, but there have few analyses about characteristics, predictive risk factors, outcomes critical patients. In this single-center retrospective case–control study, 90 adult inpatients hospitalized Tongji Hospital (Wuhan, China) were included. Demographic, clinical, laboratory tests, treatment data obtained...
Abstract Earlier studies suggested that TSP50 is a testis-specific gene encodes protein, which homologous to serine proteases but differs in threonine replaces its catalytic triad. Most importantly, it was abnormally reactivated many breast cancer biopsies tested. While further investigating biochemical and cell biological natures, we found exhibited enzyme activity located the endoplasmic reticulum cytosol membrane. During our elucidate regulatory mechanisms related differential expression,...
Abstract Background Premature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue repair and improve function. This study was performed to determine effects LIPUS on granulosa cells (GCs) apoptosis protein expression B-cell lymphoma-2 (Bcl-2) BCL2-Associated X (Bax) 4-vinylcyclohexene diepoxide (VCD)-induced POF mice investigate mechanisms function reserve capacity. Methods The current model administrated with VCD...
Journal Article A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells Get access Hao-Peng Xu, Xu Cold Spring Harbor LaboratoryPO Box 100, Harbor, NY 11724, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Riggs, Riggs Linda Rodgers, Rodgers Wigler * *To whom correspondence should be addressed Nucleic Acids Research, Volume 18, Issue 17, 11 September 1990, Page 5304,...
We have shown that the expression of mam2, gene encoding Schizosaccharomyces pombe P-factor pheromone receptor, is dependent upon components signal transduction pathway, including Ras1, Gpa1, Byr1 and Byr2, each which required for both conjugation sporulation. Studies mam2 in mutant S. cells confirm previous conclusions, based on ability to sporulate, protein kinase acts downstream Byr2 act RAS homolog, G alpha component mediates occupancy receptor. In addition, our present studies show Ras1...
Abstract Previous studies showed that the WTH3 gene functioned as a negative regulator during multidrug resistance (MDR) development in vitro. To understand whether this is also involved clinical drug resistance, hypermethylation at its promoter region observed cultured MDR MCF7/AdrR cells was examined primary drug-resistant breast cancer epithelial isolated from effusions of patients. The results event occurred and newly induced cell line, MCF7/inR. Interestingly, we found CpG (CpG 23)...
Abstract Women with premature ovarian insufficiency (POI) may be more vulnerable to a variety of health risks. To seek new method treat the disease, effects low-intensity pulsed ultrasound (LIPUS) on promoting repair injury in female SD rats induced by 4-vinylcyclohexene diepoxide (VCD) were explored this research. A total 24 subjected intraperitoneal injection VCD induce POI. Successful modeling was achieved 22 rats, which then randomized into + LIPUS group (n = 13) and 9). The control 5)...
The longer-term effects of COVID-19 on lung physiology remain poorly understood. Here, a new technique, computed cardiopulmonography (CCP), was used to study two cohorts (MCOVID and C-MORE-LP) at both ∼6 ∼12 mo after infection. CCP is comprised components. first collection highly precise, time-resolved measurements gas exchange with purpose-built molecular flow sensor based around laser absorption spectroscopy. second component estimation physiological parameters by fitting cardiopulmonary...
Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 expression and converted their resistance to sensitivity various anticancer drugs. In addition, promoter was hypermethylated MCF7/AdrR cell line primary drug resistant breast cancer epithelial cells. also found be directly targeted up regulated by p53 gene. Furthermore, over promoted apoptotic phenotype host cells.To further confirm WTH3's related characteristics, we recently employed small hairpin RNA...