A5003630372- Gut microbiota and health
- Reproductive Biology and Fertility
- Probiotics and Fermented Foods
- Gastrointestinal motility and disorders
- Genomics and Phylogenetic Studies
- Diet and metabolism studies
- Microbial Natural Products and Biosynthesis
- Clostridium difficile and Clostridium perfringens research
- Plant and animal studies
- Sperm and Testicular Function
- Aquaculture disease management and microbiota
- Prenatal Screening and Diagnostics
- Gout, Hyperuricemia, Uric Acid
- RNA and protein synthesis mechanisms
- Plant and Fungal Species Descriptions
- Assisted Reproductive Technology and Twin Pregnancy
- Plant Parasitism and Resistance
- Dietary Effects on Health
- Land Use and Ecosystem Services
- Bacteriophages and microbial interactions
- Ginseng Biological Effects and Applications
- Genomic variations and chromosomal abnormalities
- Microbial Metabolites in Food Biotechnology
- Inflammatory Biomarkers in Disease Prognosis
- Remote-Sensing Image Classification
Lingnan Normal University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
BGI Group (China)
2017-2021
First Affiliated Hospital of Zhengzhou University
2020
South Central Minzu University
2020
BGI Genomics
2019
Botswana Geoscience Institute
2019
Guangzhou Medical University
2013-2018
University of Chinese Academy of Sciences
2017-2018
Abstract Emerging evidence indicates an association between gut microbiome and arthritis diseases including gout. However, how which bacteria affect host urate degradation inflammation in gout remains unclear. Here we performed a metagenome analysis on 307 fecal samples from 102 patients 86 healthy controls. Gout metagenomes significantly differed those of The relative abundances Prevotella , Fusobacterium Bacteroides were increased gout, whereas Enterobacteriaceae butyrate-producing species...
Pre-maturation aging of immature oocytes may adversely affect the fate an oocyte. Oxidative stress is one most detrimental factors affecting oocyte developmental competence and maturation during aging. In this study, experiments were designed to examine whether supplementation antioxidants in a culture medium could protect mouse from damages caused by oxidative stress. Mouse at germinal vesicle stage prevented meiosis resumption cultured with or without for 12-36 h allow undergo After aging,...
Gymnadenia conopsea (L.) R. Br. is an important perennial terrestrial photosynthetic orchid species whose microbiomes are considered to play role in helping its germination and growth. However, the assemblage of G. root-associated microbial communities poorly understood. The compositions fungal bacterial from roots corresponding soil samples across distinct biogeographical regions two significantly different altitudes were characterized at vegetative reproductive growth stages. geographical...
Aneuploidy is one of the major factors that result in low efficiency human infertility treatment by vitro fertilization (IVF). The development DNA microarray technology allows for aneuploidy screening analyzing all 23 pairs chromosomes embryos. All chromosome more accurate than partial screening, as errors can occur any chromosome. Currently, performed developing embryos, mainly blastocysts. It has not been arrested embryos and/or compared between and from same IVF cycle.The present study...
The Bacteroidales order, widely distributed among diverse human populations, constitutes a key component of the microbiota. Members this Gram-negative order have been shown to modulate host immune system, play fundamental role in gut's microbial food webs, or be involved pathogenesis. Bacteria inhabiting such complex environment as microbiome are expected display social behaviors and, hence, possess factors that mediate cooperative and competitive interactions. Different types molecules can...
Bile salt hydrolase (BSH) is a well-known enzyme that has been commonly characterized in probiotic bacteria, as it cholesterol-lowering effects. However, its molecular investigations are scarce. Here, we build local database of BSH sequences from Lactobacillaceae (BSH⁻SDL), and phylogenetic analysis homology searches were employed to elucidate their comparability distinctiveness among species. Evolutionary study demonstrates BSH⁻SDL divided into five groups, named A, B, C, D E here, which...
Antimicrobial peptides (AMPs) are a group of small peptides, which secreted by almost all creatures in nature. They have been explored therapeutic and agricultural aspects as they toxic to many bacteria. A considerable amount work has conducted analyzing 16S metagenomics the gastrointestinal (GI) microbiome grass carp (Ctenopharyngodon idellus). However, these datasets still untapped resources. In this present study, homologous search was performed predict AMPs from our newly generated...
Fecal microbiota transplantation (FMT) is an emerging and effective therapy for the treatment of inflammatory bowel disease (IBD). Previous studies have reported that compared with FMT, whole intestinal (WIMT) can more precisely replicate community structure reduce response host. However, it remains unclear whether WIMT in alleviating IBD. To examine efficacy FMT intervention IBD, GF (Germ-free) BALB/c mice were pre-colonized or fecal before being treated dextran sodium sulfate (DSS). As...
Understanding the link between human gut virome and diseases has garnered significant interest in research community. Extracting virus-related information from metagenomic sequencing data is crucial for unravelling virus composition, host interactions, disease associations. However, current analysis workflows viral genomes vary effectiveness, posing challenges researchers seeking most up-to-date tools. To address this, we present ViromeFlowX, a user-friendly Nextflow workflow that automates...
A previous study comparing the performance of different platforms for DNA microarray found that oligonucleotide (oligo) platform containing 385K isothermal probes had best when evaluating dosage sensitivity, precision, specificity, sensitivity and copy number variations border definition. Although oligo has been used in some research fields clinics, it not aneuploidy screening human embryos. The present was designed to use this new preimplantation genetic human. total 383 blastocysts from 72...
Successful egg cryopreservation has many potential benefits to a variety of patients. However, superior standard protocol describing all aspects oocyte not yet been identified. Oocyte is still technical challenge for infertility clinics. To maintain satisfactory clinical outcomes, there need develop an easy use, efficient laboratory protocol. The present study was designed examine if human embryos resulting from eggs frozen with optimized vitrification have similar developmental competence...
Hypercholesterolemia is a major risk factor for cardiovascular disease (CVD). Probiotics are one of the most popular dietary supplements hypercholesterolemia, but there questions as to whether differences between probiotics and cholesterol-lowering drugs like atorvastatin (ATO) both in effectiveness underlying mechanisms. In this study, hypocholesterolemia effects 4 probiotic strains were investigated compared with ATO, focusing on their impacts gut microbiota. A hypercholesterolemia model...
Gut microbiomes in various fish species were widely investigated with the rapid development of next-generation sequencing technologies. However, little is known about gastrointestinal (GI) microbial communities mudskippers, a representative group marine amphibious fishes, and their comparisons other vertebrate animals from different habitats. Here, we performed comprehensive analysis on composition five groups (including freshwater aquatic amphibians, terrestrial animals) via operational...
Under the background of urbanization strategy, ecological environmental issues have become increasingly prominent as urban clusters develop rapidly. However, factors causing problems are extremely complex, and it is difficult to determine causal relationships strength effects between influencing quality. In this study, we took 277 townships in western part Guangdong Province research units used GEE platform Landsat remote sensing images construct Remote Sensing Ecological Index (RSEI)...
The implementation of several global microbiome studies has yielded extensive insights into the biosynthetic potential natural microbial communities. However, on distribution classes ribosomally synthesized and post-translationally modified peptides (RiPPs), non-ribosomal (NRPs) polyketides (PKs) in different large ecosystems have been very limited. Here, we collected a set metagenome-assembled bacterial genomes from marine, freshwater terrestrial to investigate these bacteria. We...
CK1 (casein kinase 1) is a family of serine/threonine protein that ubiquitously expressed in eukaryotic organism. members are involved the regulation many cellular processes. Particularly, was reported to phosphorylate Rec8 subunits cohesin complex and regulate chromosome segregation meiosis budding yeast fission yeast. (1-3) Here we investigated expression, subcellular localization potential functions CK1α, CK1δ CK1ε during mouse oocyte meiotic maturation. We found all concentrated at...
In the phase of oxygen limitation during Aspergillus niger fermentation, cell growth decreased, while yield glucoamylase increased continuously and significantly. Explanation on changes transcriptome profile this process may improve our understanding mechanisms adaption enzyme production in A. niger. The transcriptomic data from 4 time points a strain were analyzed. Hierarchical clustering all samples showed that strongest transcriptional response occurred between early middle stage...