A5088861669- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Occupational Health and Performance
- Sports injuries and prevention
- Long-Term Effects of COVID-19
- Heart Rate Variability and Autonomic Control
- Musculoskeletal pain and rehabilitation
- Prosthetics and Rehabilitation Robotics
- Psoriasis: Treatment and Pathogenesis
- Total Knee Arthroplasty Outcomes
- Muscle activation and electromyography studies
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone and Joint Diseases
- Non-Invasive Vital Sign Monitoring
- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Cardiac Arrest and Resuscitation
- Shoulder Injury and Treatment
- Cardiovascular and exercise physiology
- Trauma and Emergency Care Studies
- Bone fractures and treatments
- COVID-19 and Mental Health
- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
Imperial College London
2016-2025
Medical Defence Union
2023-2024
Lung Institute
2017-2024
Royal Navy
2016-2024
Nottingham Biomedical Research Centre
2023
Ministry of Defence
2018-2023
Government of the United Kingdom
2018-2023
Loughborough University
2021-2023
Royal Rehabilitation Centre
2013-2023
Loughborough College
2022
The highly infectious and pathogenic novel coronavirus (CoV), severe acute respiratory syndrome (SARS)-CoV-2, has emerged causing a global pandemic. Although COVID-19 predominantly affects the system, evidence indicates multisystem disease which is frequently often results in death. Long-term sequelae of are unknown, but from previous CoV outbreaks demonstrates impaired pulmonary physical function, reduced quality life emotional distress. Many survivors who require critical care may develop...
Magnetic resonance imaging (MRI) is increasingly used to detect sacroiliitis earlier. This study was undertaken investigate what proportion of patients with MRI-evident develop ankylosing spondylitis (AS) in the long term and whether there are predictors outcome.Consecutive undiagnosed early inflammatory back pain (IBP) (of <2 years' duration) were assessed clinically radiologically. Baseline assessments included fat-suppressed MRI sequences sacroiliac joints lumbar spine that scored for...
Abstract Objective To evaluate the efficacy of infliximab in HLA–B27–positive patients with magnetic resonance imaging (MRI)–determined early sacroiliitis, using both clinical and MRI assessments. Methods Forty recent‐onset inflammatory back pain, as assessed by Calin criteria, HLA–B27 positivity, disease activity measured Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), pain morning stiffness, sacroiliac joint bone edema were randomized a double‐blind manner to receive 5 mg/kg...
Objectives The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for lesions in the sacroiliac joint (SIJ) patients with spondyloarthritis (SpA), and conduct preliminary validation. Methods literature pertaining these lesion discussed at three meetings group. 25 investigators (20 rheumatologists, 5 radiologists) determined which should be retained or required revision, new definition....
The precise anatomical location of pathology associated with inflammatory back pain (IBP) in early spondyloarthropathy (SpA) remains unclear.To use MRI to study the sacroiliac joint (SIJ) and lumbar spine (LS) explore relationship between sites extent inflammation HLA-B27 status over 12 months.54 patients IBP; median duration 24 weeks (54% positive; Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) 5.65) 22 control subjects (11 mechanical pain; 11 volunteers) were recruited 63% (n...
Musculoskeletal injuries during initial military training are a significant medical problem facing organisations globally. In order to develop an injury management programme, this study aims quantify the incidence and rehabilitation times for specific diagnoses.This was prospective follow-up of musculoskeletal in 6608 British Army recruits 26-week programme over 2-year period. Incidence diagnoses were recorded analysed.During period overall 48.6%, most common diagnosis iliotibial band...
Background: There is growing evidence to support the use of low-load blood flow restriction (LL-BFR) exercise in musculoskeletal rehabilitation. Purpose: The purpose this study was evaluate efficacy and feasibility restricted training versus conventional high mechanical load resistance (RT) on clinical outcomes patient's undergoing inpatient multidisciplinary team (MDT) Study design: A single-blind randomized controlled study. Methods: Twenty-eight lower-limb injured adults completed a...
Introduction There have been more than 425 million COVID-19 infections worldwide. Post-COVID illness has become a common, disabling complication of this infection. Therefore, it presents significant challenge to global public health and economic activity. Methods Comprehensive clinical assessment (symptoms, WHO performance status, cognitive testing, CPET, lung function, high-resolution CT chest, pulmonary angiogram cardiac MRI) previously well, working-age adults in full-time employment was...
Subjective exercise limiting symptoms such as fatigue and shortness of breath reduce but remain prevalent in symptomatic groups. At 12 mo, COVID-19-exposed individuals still have a reduced capacity for work at the anaerobic threshold (which best predicts sustainable intensity), despite oxygen uptake comparable to controls. The prevalence considered “medically non-deployable” remains high 47%.
Pituitary dysfunction is a recognized consequence of traumatic brain injury (TBI) that causes cognitive, psychological, and metabolic impairment. Hormone replacement offers therapeutic opportunity. Blast TBI (bTBI) from improvised explosive devices commonly seen in soldiers returning recent conflicts. We investigated: (1) the prevalence consequences pituitary following moderate to severe bTBI (2) whether it associated with particular patterns injury.Nineteen male (median age = 28.3 years) 39...
BackgroundThe long-term psychosocial outcomes of UK armed forces personnel who sustained serious combat injuries during deployment to Afghanistan are largely unknown. We aimed assess rates probable post-traumatic stress disorder (PTSD), depression, anxiety, and mental health-associated multimorbidity in a representative sample serving ex-serving military with injuries, compared matched uninjured personnel.MethodsThis analysis used baseline data from the ADVANCE cohort study, which injured...
A failure to fully recover following coronavirus disease 2019 (COVID-19) may have a profound impact on high-functioning populations ranging from frontline emergency services professional or amateur/recreational athletes. The aim of the study is describe medium-term cardiopulmonary exercise profiles individuals with "persistent symptoms" and who feel "recovered" after hospitalization mild-moderate community infection COVID-19 an age, sex, job-role matched control group. total 113 participants...
BackgroundChronic pain after injury poses a serious health burden. As result of advances in medical technology, ever more military personnel survive severe combat injuries, but long-term outcomes are unknown. We aimed to assess rates representative sample UK with and without injuries.MethodsWe used data from the ADVANCE cohort study (ISRCTN57285353). Individuals deployed as armed forces Afghanistan were recruited include those physical frequency-matched uninjured comparison group....
Objective. To investigate the long-term response to biological therapies in AS a real life clinical setting and quantify non-response 'switching' these cases. Methods. All patients prescribed TNF-blocking for between 1999 2006 were studied. Response was evaluated using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Functional (BASFI) CRP results. Results. A total of 113 (84 males: 29 females, mean age 45 yrs, median disease duration 16 87% HLA-B27 positive) identified. At...
Abstract Background Appendicectomy for acute appendicitis in children may be performed specialist centres by paediatric surgeons or general surgery units. Service provision and outcome of appendicectomy differ between such Methods This multicentre observational study included all (aged less than 16 years) who had an at either a unit unit. The primary was normal rate (NAR). Secondary outcomes 30-day adverse events, use ultrasound imaging laparoscopy, consultant involvement procedures. Results...
To develop evidence-based recommendations on the use of MRI in diagnosis axial SpA (axSpA).A working group comprising nine rheumatologists and musculoskeletal radiologists with an interest axSpA was established, support from British Society Spondyloarthritis (BRITSpA). Two meetings were held. In first meeting, research questions formulated. second results a systematic literature review designed to inform reviewed. An anonymized Delphi process used formulate final set recommendations. For...
Background: Medical practitioners face difficult decisions over whether to amputate or salvage a lower limb that has undergone trauma. To our knowledge, there been little evidence reporting the impact of different surgical on functional and mental health outcomes following intensive rehabilitation might inform decision-making. Methods: This study is retrospective, independent-group comparison from U.K. military complex trauma center. There were 100 procedures examined: 36 unilateral...
Abstract Background The COVID-19 pandemic has led to significant morbidity and mortality, with the former impacting limiting individuals requiring high physical fitness, including sportspeople emergency services. Methods Observational cohort study of 4 groups: hospitalised, community illness on-going symptoms (community-symptomatic), now recovered (community-recovered) comparison. A total 113 participants (aged 39 ± 9, 86% male) were recruited: hospitalised ( n = 35), community-symptomatic...
Introduction The Afghanistan war (2003–2014) was a unique period in military medicine. Many service personnel survived injuries of severity that would have been fatal at any other time history; the long-term health outcomes such are unknown. A rme D Ser V ices Tr uma and Rehabilitatio N Out C om E (ADVANCE) study aims to determine effects on both medical psychosocial servicemen surviving this severe combat related trauma. Methods analysis ADVANCE is prospective cohort study. 1200...
The association between combat-related traumatic injury (CRTI) and cardiovascular risk is uncertain. This study aimed to investigate the CRTI both metabolic syndrome (MetS) arterial stiffness.This was a prospective observational cohort consisting of 579 male adult UK combat veterans (UK-Afghanistan War 2003-2014) with who were frequency-matched 565 uninjured men by age, service, rank, regiment, deployment period role-in-theatre. Measures included quantification severity (New Injury Severity...