Nick P. Talbot
A5047349436- High Altitude and Hypoxia
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Cancer, Hypoxia, and Metabolism
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Air Quality and Health Impacts
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Iron Metabolism and Disorders
- COVID-19 and healthcare impacts
- Climate Change and Health Impacts
- Asthma and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Air Quality Monitoring and Forecasting
- Cystic Fibrosis Research Advances
- SARS-CoV-2 and COVID-19 Research
- Hemoglobinopathies and Related Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Travel-related health issues
- Atmospheric chemistry and aerosols
University of Oxford
2016-2025
Oxford University Hospitals NHS Trust
2013-2025
Oxford BioMedica (United Kingdom)
2020-2024
Imperial College London
2022-2024
University of Auckland
2020-2023
NIHR Leicester Biomedical Research Centre
2023
University of Leicester
2023
University Hospitals of Leicester NHS Trust
2023
University of Manchester
2019-2023
Manchester Academic Health Science Centre
2023
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
The extent to which immune responses natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization vaccines protect against variants of concern (VOC) is increasing importance. Accordingly, here we analyse antibodies T cells a recently vaccinated, UK cohort, alongside those recovering from in early 2020. We show that neutralization the VOC compared reference isolate original circulating lineage, B, reduced: more profoundly B.1.351 than for B.1.1.7, or...
The longitudinal trajectories of cardiopulmonary abnormalities and symptoms following infection with coronavirus disease (COVID-19) are unclear. We sought to describe their natural history in previously hospitalised patients, compare this controls, assess the relationship between impairment at 6 months post-COVID-19.
Background The SARS-Cov-2 Omicron variant demonstrates rapid spread but reduced disease severity. Studies evaluating lung imaging findings of infection versus non-Omicron remain lacking. Purpose To compare the with SARS-CoV-2 Delta according to their chest CT radiologic pattern, biochemical parameters, clinical severity, and hospital outcomes after adjusting for vaccination status. Materials Methods This retrospective study included hospitalized adult patients reverse...
Importance Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure has been associated reduced mortality. Objectives To assess efficacy safety landiolol in patients tachycardia established requiring prolonged (>24 hours) vasopressor support. Design, Setting, Participants An open-label, multicenter, randomized trial involving 126 adults (≥18...
Background The von Hippel–Lindau tumour suppressor protein–hypoxia-inducible factor (VHL–HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular responses to hypoxia, yet insights into its role in systemic human physiology remain limited. Chuvash polycythaemia recently been defined new form of VHL-associated disease, distinct from the classical inherited cancer syndrome, which germline homozygosity for hypomorphic VHL allele causes generalised...
Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at high altitude. Recent work has established that the effect hypoxia on arterial pressure may depend iron status, possibly acting through transcription factor hypoxia-inducible factor, but pathophysiological clinical importance this interaction unknown.To determine whether increasing or decreasing availability modifies altitude-induced hypoxic hypertension.Two randomized, double-blind, placebo-controlled protocols...
Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia-inducible (HIF) central to this process. The oxygen-sensing iron-dependent dioxygenase enzymes that regulate HIF are highly sensitive varying iron availability. It unknown whether similarly influences vasculature. This human physiology study aimed determine availability affects arterial pressure and vascular response hypoxia, as predicted biochemically role HIF. In controlled...
Tibetan natives have lived on the plateau (altitude ∼4,000 m) for at least 25,000 years, and as such they are adapted to life reproduction in a hypoxic environment. Recent studies identified two genetic loci, EGLN1 EPAS1, that undergone natural selection Tibetans, further demonstrated an association of EGLN1/ EPAS1 genotype with hemoglobin concentration. Both genes encode major components hypoxia-inducible factor (HIF) transcriptional pathway, which coordinates organism's response hypoxia....
Abstract Background The medium-term effects of Coronavirus disease (COVID-19) on multiple organ health, exercise capacity, cognition, quality life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge 30 comorbidity-matched controls were prospectively enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments. Findings...
Introduction There have been more than 425 million COVID-19 infections worldwide. Post-COVID illness has become a common, disabling complication of this infection. Therefore, it presents significant challenge to global public health and economic activity. Methods Comprehensive clinical assessment (symptoms, WHO performance status, cognitive testing, CPET, lung function, high-resolution CT chest, pulmonary angiogram cardiac MRI) previously well, working-age adults in full-time employment was...
Hypercapnia has been shown in animal experiments to induce pulmonary hypertension. This study measured the sensitivity and time course of human vascular response sustained (4 h) hypercapnia hypocapnia. Twelve volunteers undertook three protocols: 1) 4-h euoxic (end-tidal Po(2) = 100 Torr) Pco(2) was 10 Torr above normal), followed by 2 h recovery with eucapnia; 2) hypocapnia below normal) recovery; 3) 6-h air breathing (control). Pulmonary resistance assessed at 0.5- 1-h intervals using...
The time course of the pulmonary vascular response to hypoxia in humans has not been fully defined. In this investigation, study A was designed assess form increase tone at onset and determine whether a steady plateau ensues over following approximately 20 min. Twelve volunteers were exposed twice 5 min isocapnic euoxia (end-tidal Po(2) = 100 Torr), 25 50 finally euoxia. Study B look for slower response, and, if possible, latency process. Seven euoxia, 105 hypoxia, 10 For both studies,...
The hypoxia-inducible factors (HIFs; isoforms HIF-1α, HIF-2α, HIF-3α) mediate many responses to hypoxia. Their regulation is principally by oxygen-dependent degradation, which initiated hydroxylation of specific proline residues followed binding von Hippel-Lindau (VHL) protein. Chuvash polycythemia a disorder with elevated HIF. It arises through germline homozygosity for hypomorphic VHL alleles and has phenotype hematological, cardiopulmonary, metabolic abnormalities. This study explores the...
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospective study aimed assess whether successful awake COVID-19, respiratory support (continuous positive airways pressure (CPAP) or high-flow nasal oxygen (HFNO)) a high-dependency unit (HDU), associated improved outcomes. HDU care included by physiotherapists....
Abstract The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study UK healthcare workers prior vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show highly variable range responses, some which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B memory ELISpot) stable. use...
Key points Arterial hypoxaemia leads to a rapid increase in ventilation. If the is sustained, further ventilation develops over hours days process termed ventilatory acclimatisation. Studies transgenic mice implicate hypoxia‐inducible factor (HIF) pathway latter process. The aim of this study was investigate role HIF prolyl hydroxylase (PHD) enzymes We find that PHD2 +/− , but not PHD1 −/− or PHD3 mimic chronic hypoxia exhibiting exaggerated responses acute hypoxia. This associated with...
Abstract Background The COVID-19 pandemic has led to significant morbidity and mortality, with the former impacting limiting individuals requiring high physical fitness, including sportspeople emergency services. Methods Observational cohort study of 4 groups: hospitalised, community illness on-going symptoms (community-symptomatic), now recovered (community-recovered) comparison. A total 113 participants (aged 39 ± 9, 86% male) were recruited: hospitalised ( n = 35), community-symptomatic...